Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
A-769662 C20H12N2O3S 360.39 AMPK Activator Cool B. (2006) Cell Metabolism 3 403-416 US7119205 Tocris Download

Results as Barchart

View results as a bar chart
50µM
10µM
100µM

Results as Table

Screening Concentration: 100µM
Kinase % Activity Remaining Standard Deviation
MKK1 29 3
MKK2 19 0
MKK6 84 10
ERK1 63 11
ERK2 49 10
JNK1 93 8
JNK2 88 1
JNK3 62 11
p38 alpha MAPK 90 5
p38 beta MAPK 77 3
p38 gamma MAPK 83 6
p38 delta MAPK 124 10
ERK8 24 4
RSK1 12 5
RSK2 13 2
PDK1 90 2
PKB alpha 78 2
PKB beta 11 2
SGK1 48 1
S6K1 38 1
PKA 95 10
ROCK 2 75 5
PRK2 59 2
PKC alpha 90 11
PKC zeta 28 6
PKD1 24 1
MSK1 42 7
MNK1 93 5
MNK2 86 1
MAPKAP-K2 30 4
MAPKAP-K3 8 3
PRAK 15 4
CAMKK beta 78 4
CAMK1 7 1
SmMLCK 20 0
PHK 73 1
DAPK1 83 5
CHK1 43 3
CHK2 33 3
GSK3 beta 46 6
CDK2-Cyclin A 121 0
PLK1 25 2
Aurora A 64 4
Aurora B 22 2
LKB1 65 6
AMPK 62 5
MARK1 68 6
MARK2 49 2
MARK3 38 4
MARK4 45 4
BRSK1 51 4
BRSK2 28 1
MELK 21 0
NUAK1 10 0
CK1 delta 88 4
CK2 86 5
DYRK1A 26 3
DYRK2 33 2
DYRK3 6 1
NEK2a 19 0
NEK6 137 5
IKK beta 39 3
IKK epsilon 12 0
TBK1 29 2
PIM1 7 1
PIM2 18 1
PIM3 7 2
SRPK1 35 1
EF2K 64 5
HIPK1 35 2
HIPK2 19 3
HIPK3 43 6
CLK2 30 4
PAK2 63 8
PAK4 41 2
PAK5 39 1
PAK6 82 8
MST2 20 0
MST4 14 0
GCK 14 2
MINK1 5 0
MEKK1 7 0
MLK1 18 2
MLK3 4 1
TAO1 18 1
ASK1 250 7
TAK1 72 8
IRAK4 34 3
RIPK2 139 3
TTK 48 1
Src 10 1
Lck 58 5
CSK 82 10
YES1 16 0
BTK 10 1
JAK2 32 1
SYK 42 10
EPH-A2 40 5
EPH-A4 64 4
EPH-B1 97 4
EPH-B2 13 2
EPH-B3 55 4
EPH-B4 49 4
FGF-R1 50 8
HER4 8 4
IGF-1R 65 5
IR 69 9
IRR 51 6
TrkA 28 4
VEGFR1 11 2
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 79 1
MKK2 74 3
MKK6 85 15
ERK1 83 3
ERK2 103 8
JNK1 99 5
JNK2 94 1
JNK3 75 3
p38 alpha MAPK 97 2
p38 beta MAPK 89 2
p38 gamma MAPK 95 3
p38 delta MAPK 107 7
ERK8 81 3
RSK1 80 7
RSK2 74 4
PDK1 93 3
PKB alpha 94 0
PKB beta 56 5
SGK1 103 1
S6K1 78 1
PKA 89 1
ROCK 2 91 2
PRK2 85 8
PKC alpha 94 6
PKC zeta 96 7
PKD1 62 6
MSK1 69 3
MNK1 104 2
MNK2 102 3
MAPKAP-K2 77 1
MAPKAP-K3 57 1
PRAK 52 4
CAMKK beta 87 5
CAMK1 68 3
SmMLCK 76 2
PHK 96 0
DAPK1 107 1
CHK1 69 2
CHK2 79 4
GSK3 beta 80 1
CDK2-Cyclin A 100 3
PLK1 88 1
Aurora A 93 7
Aurora B 53 0
LKB1 86 3
AMPK 135 15
MARK1 59 3
MARK2 64 4
MARK3 78 4
MARK4 92 6
BRSK1 76 5
BRSK2 64 4
MELK 46 1
NUAK1 61 7
CK1 delta 88 5
CK2 110 5
DYRK1A 75 3
DYRK2 63 0
DYRK3 54 6
NEK2a 73 1
NEK6 104 6
IKK beta 86 0
IKK epsilon 69 4
TBK1 67 8
PIM1 26 2
PIM2 71 5
PIM3 18 1
SRPK1 107 0
EF2K 89 4
HIPK1 74 7
HIPK2 99 6
HIPK3 97 1
CLK2 81 2
PAK2 94 2
PAK4 52 8
PAK5 58 2
PAK6 69 3
MST2 60 10
MST4 74 5
GCK 76 5
MINK1 65 6
MEKK1 26 5
MLK1 59 4
MLK3 43 6
TAO1 83 4
ASK1 140 5
TAK1 83 3
IRAK4 82 4
RIPK2 110 4
TTK 76 2
Src 44 5
Lck 88 5
CSK 79 2
YES1 96 7
BTK 52 5
JAK2 83 6
SYK 106 0
EPH-A2 82 7
EPH-A4 93 1
EPH-B1 110 6
EPH-B2 93 5
EPH-B3 81 11
EPH-B4 82 8
FGF-R1 109 11
HER4 33 7
IGF-1R 94 8
IR 103 1
IRR 88 5
TrkA 69 2
VEGFR1 65 4
Screening Concentration: 50µM
Kinase % Activity Remaining Standard Deviation
MKK1 27 10
ERK1 102 3
ERK2 74 2
JNK1 102 3
JNK2 89 10
JNK3 70 4
p38 alpha MAPK 122 12
p38 beta MAPK 84 4
p38 gamma MAPK 80 6
p38 delta MAPK 116 12
ERK8 36 4
RSK1 9 0
RSK2 27 7
PDK1 81 0
PKB alpha 62 1
PKB beta 37 5
SGK1 54 1
S6K1 66 5
PKA 41 10
ROCK 2 49 7
PRK2 85 9
PKC alpha 60 0
PKC zeta 67 6
PKD1 25 12
MSK1 39 4
MNK1 66 4
MNK2 80 4
MAPKAP-K2 32 2
MAPKAP-K3 48 1
PRAK 25 1
CAMKK beta 48 9
CAMK1 45 0
SmMLCK 39 12
PHK 65 3
CHK1 98 4
CHK2 52 4
GSK3 beta 17 4
CDK2-Cyclin A 84 6
PLK1 28 1
Aurora B 25 2
Aurora C 30 4
AMPK 67 3
MARK3 87 4
BRSK2 63 4
MELK 64 5
CK1 delta 60 6
CK2 95 0
DYRK1A 60 10
DYRK2 84 0
DYRK3 47 4
NEK2a 52 9
NEK6 94 8
NEK7 102 4
IKK beta 60 0
IKK epsilon 47 1
TBK1 55 4
PIM1 5 0
PIM2 17 0
PIM3 5 0
SRPK1 42 8
EF2K 73 3
HIPK2 58 2
HIPK3 52 2
PAK4 38 0
PAK5 50 6
PAK6 92 11
MST2 36 0
MST4 57 3
Src 65 13
Lck 58 4
CSK 46 1
YES1 13 2
SYK 36 3
EPH-A2 64 6
FGF-R1 95 11
IRR 90 4

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