Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
A-443654 C24H23ON5x2HCl 470.39 Akt1 Shi Y. (2005) Neoplasia 7 992-1000. WO2007106884 AdooQ Bioscience Download

Results as Barchart

View results as a bar chart
0.01µM
0.1µM

Results as Table

Screening Concentration: 0.01µM
Kinase % Activity Remaining Standard Deviation
MKK1 84 2
ERK1 77 8
ERK2 78 6
JNK1 89 7
JNK2 94 1
JNK3 81 9
p38 alpha MAPK 131 2
p38 beta MAPK 114 3
p38 gamma MAPK 87 5
p38 delta MAPK 86 1
ERK8 61 2
RSK1 78 1
RSK2 74 3
PDK1 88 1
PKB alpha 5 2
PKB beta 17 2
SGK1 78 2
S6K1 88 3
PKA 26 1
ROCK 2 48 3
PRK2 17 2
PKC alpha 73 3
PKC zeta 82 3
PKD1 63 3
MSK1 19 2
MNK1 120 3
MNK2 97 2
MAPKAP-K2 92 8
MAPKAP-K3 91 9
PRAK 107 3
CAMKK alpha 112 2
CAMKK beta 83 8
CAMK1 89 3
SmMLCK 69 2
PHK 86 7
CHK1 100 3
CHK2 94 8
GSK3 beta 81 1
CDK2-Cyclin A 82 5
PLK1 89 5
Aurora B 81 3
Aurora C 100 4
AMPK 84 8
MARK3 100 3
BRSK2 88 9
MELK 96 2
CK1 delta 95 3
CK2 96 0
DYRK1A 10 2
DYRK2 79 5
DYRK3 41 3
NEK2a 101 5
NEK6 95 2
NEK7 86 8
IKK beta 93 8
PIM1 57 8
PIM2 59 0
PIM3 54 6
SRPK1 92 8
EF2K 93 7
HIPK2 73 2
HIPK3 90 0
PAK4 99 3
PAK5 104 2
PAK6 87 2
MST2 76 4
Src 91 0
Lck 97 8
CSK 99 2
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 67 6
ERK1 59 3
ERK2 64 2
JNK1 90 3
JNK2 78 9
JNK3 86 8
p38 alpha MAPK 92 6
p38 beta MAPK 105 4
p38 gamma MAPK 83 4
p38 delta MAPK 68 9
ERK8 28 3
RSK1 32 1
RSK2 27 3
PDK1 79 8
PKB alpha 3 2
PKB beta 2 0
SGK1 53 5
S6K1 32 9
PKA 3 1
ROCK 2 8 1
PRK2 2 2
PKC alpha 29 4
PKC zeta 66 0
PKD1 23 4
MSK1 9 2
MNK1 109 2
MNK2 80 5
MAPKAP-K2 73 0
MAPKAP-K3 96 2
PRAK 107 4
CAMKK alpha 117 1
CAMKK beta 63 9
CAMK1 77 6
SmMLCK 27 2
PHK 54 6
CHK1 99 2
CHK2 95 2
GSK3 beta 33 4
CDK2-Cyclin A 31 2
PLK1 80 1
Aurora B 80 2
Aurora C 92 8
AMPK 67 3
MARK3 83 1
BRSK2 79 1
MELK 63 2
CK1 delta 74 3
CK2 90 8
DYRK1A 7 3
DYRK2 26 1
DYRK3 8 1
NEK2a 95 2
NEK6 95 4
NEK7 84 1
IKK beta 89 2
PIM1 15 2
PIM2 15 2
PIM3 13 1
SRPK1 91 2
EF2K 94 8
HIPK2 24 3
HIPK3 71 2
PAK4 90 6
PAK5 96 1
PAK6 87 3
MST2 29 0
Src 86 5
Lck 97 3
CSK 93 7

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