Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
TTT-3002 LRRK2 Yao C (2012) Hum Mol Genet. Download

Results as Barchart

View results as a bar chart
0.01µM
0.1µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 0 1
MKK2 14 3
MKK6 5 4
ERK1 2 1
ERK2 5 0
ERK5 12 1
JNK1 1 0
JNK2 4 0
JNK3 26 4
p38 alpha MAPK 105 8
p38 beta MAPK 79 5
p38 gamma MAPK 6 3
p38 delta MAPK 48 3
ERK8 11 4
RSK1 1 0
RSK2 6 0
PDK1 2 0
PKB alpha 5 1
PKB beta 8 0
SGK1 10 1
S6K1 3 0
PKA 2 0
ROCK 2 7 1
PRK2 6 4
PKC alpha 23 20
PKC gamma 13 1
PKC zeta 15 0
PKD1 16 4
STK33 23 3
MSK1 2 0
MNK1 9 2
MNK2 10 6
MAPKAP-K2 -1 2
MAPKAP-K3 29 2
PRAK 2 0
CAMKK beta 11 3
CAMK1 4 1
SmMLCK 1 1
PHK 1 0
DAPK1 4 2
CHK1 3 1
CHK2 2 0
GSK3 beta 7 1
CDK2-Cyclin A 8 2
CDK9-Cyclin T1 15 8
PLK1 22 3
Aurora A 5 1
Aurora B 39 3
TLK1 6 0
LKB1 35 1
AMPK 1 0
AMPK (hum) 1 1
MARK1 5 2
MARK2 4 1
MARK3 2 1
MARK4 1 0
BRSK1 1 0
BRSK2 8 2
MELK 5 2
NUAK1 1 1
SIK2 1 1
SIK3 2 2
TSSK1 4 1
CK1 gamma 2 86 10
CK1 delta 96 3
CK2 80 5
TTBK1 99 0
TTBK2 90 10
DYRK1A 3 1
DYRK2 4 1
DYRK3 2 0
NEK2a 66 1
NEK6 72 9
IKK beta 6 1
IKK epsilon 2 3
TBK1 12 9
PIM1 1 0
PIM2 4 1
PIM3 10 2
SRPK1 11 0
EF2K 79 9
EIF2AK3 36 6
HIPK1 22 1
HIPK2 6 0
HIPK3 10 0
CLK2 -1 1
PAK2 4 1
PAK4 7 9
PAK5 2 0
PAK6 1 0
MST2 9 9
MST3 6 2
MST4 20 5
GCK 2 1
MAP4K3 1 1
MAP4K5 4 2
MINK1 2 0
MEKK1 23 6
MLK1 2 1
MLK3 3 0
TESK1 2 0
TAO1 7 1
ASK1 2 0
TAK1 2 0
IRAK1 3 1
IRAK4 4 0
RIPK2 9 1
OSR1 7 0
TTK 7 1
MPSK1 69 2
WNK1 86 12
ULK1 11 0
ULK2 1 0
TGFBR1 17 1
Src 6 1
Lck 3 3
CSK 20 2
YES1 2 0
ABL 37 0
BTK 9 9
JAK2 7 0
SYK 2 1
ZAP70 2 0
TIE2 20 14
BRK 4 1
EPH-A2 19 3
EPH-A4 16 2
EPH-B1 25 12
EPH-B2 34 4
EPH-B3 83 4
EPH-B4 8 1
FGF-R1 3 0
HER4 14 4
IGF-1R 3 0
IR 11 5
IRR 9 1
TrkA 2 1
DDR2 3 1
VEGFR1 4 5
PDGFRA 2 3
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 0 1
MKK2 17 14
MKK6 13 11
ERK1 4 1
ERK2 6 1
ERK5 24 4
JNK1 4 1
JNK2 98 9
JNK3 30 0
p38 alpha MAPK 109 3
p38 beta MAPK 96 6
p38 gamma MAPK 29 1
p38 delta MAPK 97 0
ERK8 8 13
RSK1 3 1
RSK2 7 1
PDK1 2 1
PKB alpha 44 15
PKB beta 51 0
SGK1 32 1
S6K1 6 1
PKA 5 1
ROCK 2 49 39
PRK2 8 2
PKC alpha 44 9
PKC gamma 51 2
PKC zeta 56 2
PKD1 17 4
STK33 27 3
MSK1 10 1
MNK1 16 0
MNK2 12 2
MAPKAP-K2 0 4
MAPKAP-K3 74 0
PRAK 15 1
CAMKK beta 14 2
CAMK1 25 1
SmMLCK 4 2
PHK 1 0
DAPK1 18 1
CHK1 4 1
CHK2 5 0
GSK3 beta 15 6
CDK2-Cyclin A 9 1
CDK9-Cyclin T1 17 1
PLK1 38 5
Aurora A 4 0
Aurora B 46 1
TLK1 39 4
LKB1 50 3
AMPK 2 0
AMPK (hum) 3 3
MARK1 5 1
MARK2 5 0
MARK3 3 2
MARK4 2 0
BRSK1 3 0
BRSK2 10 1
MELK 10 2
NUAK1 2 0
SIK2 0 0
SIK3 7 4
TSSK1 5 2
CK1 gamma 2 97 4
CK1 delta 107 14
CK2 108 11
TTBK1 108 4
TTBK2 102 17
DYRK1A 8 1
DYRK2 9 1
DYRK3 4 1
NEK2a 105 8
NEK6 89 14
IKK beta 24 0
IKK epsilon 1 4
TBK1 16 11
PIM1 16 1
PIM2 30 2
PIM3 10 5
SRPK1 53 2
EF2K 97 14
EIF2AK3 59 8
HIPK1 82 4
HIPK2 30 1
HIPK3 43 8
CLK2 -1 1
PAK2 19 3
PAK4 7 5
PAK5 4 0
PAK6 2 0
MST2 16 8
MST3 50 2
MST4 26 3
GCK 4 0
MAP4K3 2 1
MAP4K5 7 1
MINK1 3 1
MEKK1 78 11
MLK1 2 0
MLK3 5 0
TESK1 19 4
TAO1 15 5
ASK1 15 3
TAK1 2 1
IRAK1 2 2
IRAK4 7 2
RIPK2 26 3
OSR1 23 1
TTK 13 1
MPSK1 85 5
WNK1 91 9
ULK1 43 0
ULK2 5 1
TGFBR1 74 1
Src 19 3
Lck 13 5
CSK 73 6
YES1 20 4
ABL 82 8
BTK 11 4
JAK2 12 8
SYK 6 2
ZAP70 16 6
TIE2 41 1
BRK 16 4
EPH-A2 53 6
EPH-A4 61 4
EPH-B1 56 4
EPH-B2 89 13
EPH-B3 100 4
EPH-B4 60 2
FGF-R1 22 4
HER4 63 0
IGF-1R 64 12
IR 76 16
IRR 12 2
TrkA 3 0
DDR2 8 1
VEGFR1 13 10
PDGFRA 8 1
Screening Concentration: 0.01µM
Kinase % Activity Remaining Standard Deviation
MKK1 9 5
MKK2 32 13
MKK6 10 7
ERK1 38 21
ERK2 22 0
ERK5 66 4
JNK1 91 8
JNK2 101 12
JNK3 65 2
p38 alpha MAPK 106 2
p38 beta MAPK 108 5
p38 gamma MAPK 76 2
p38 delta MAPK 100 0
ERK8 48 1
RSK1 9 1
RSK2 16 0
PDK1 17 1
PKB alpha 93 3
PKB beta 109 1
SGK1 79 6
S6K1 37 6
PKA 29 4
ROCK 2 82 5
PRK2 21 5
PKC alpha 79 16
PKC gamma 95 4
PKC zeta 110 6
PKD1 21 6
STK33 44 10
MSK1 41 2
MNK1 61 3
MNK2 93 4
MAPKAP-K2 19 3
MAPKAP-K3 91 8
PRAK 81 0
CAMKK beta 64 4
CAMK1 97 10
SmMLCK 48 1
PHK 17 21
DAPK1 51 3
CHK1 11 0
CHK2 24 5
GSK3 beta 51 11
CDK2-Cyclin A 18 6
CDK9-Cyclin T1 61 19
PLK1 68 17
Aurora A 28 2
Aurora B 49 5
TLK1 93 4
LKB1 103 1
AMPK 6 0
AMPK (hum) 4 1
MARK1 11 3
MARK2 11 0
MARK3 7 0
MARK4 10 2
BRSK1 61 4
BRSK2 16 1
MELK 18 5
NUAK1 2 1
SIK2 4 0
SIK3 31 5
TSSK1 13 1
CK1 gamma 2 106 4
CK1 delta 109 2
CK2 106 14
TTBK1 101 8
TTBK2 107 8
DYRK1A 29 1
DYRK2 41 2
DYRK3 24 1
NEK2a 105 1
NEK6 87 5
IKK beta 75 9
IKK epsilon 6 0
TBK1 22 12
PIM1 71 0
PIM2 93 2
PIM3 17 2
SRPK1 89 4
EF2K 105 6
EIF2AK3 62 2
HIPK1 98 5
HIPK2 85 3
HIPK3 83 9
CLK2 9 5
PAK2 71 11
PAK4 25 14
PAK5 17 2
PAK6 29 5
MST2 18 13
MST3 97 12
MST4 86 2
GCK 6 0
MAP4K3 3 0
MAP4K5 10 2
MINK1 4 0
MEKK1 97 1
MLK1 3 0
MLK3 17 3
TESK1 76 9
TAO1 53 6
ASK1 113 4
TAK1 111 16
IRAK1 15 3
IRAK4 7 1
RIPK2 80 5
OSR1 75 10
TTK 37 2
MPSK1 102 4
WNK1 103 26
ULK1 102 8
ULK2 30 1
TGFBR1 96 3
Src 78 5
Lck 44 4
CSK 112 10
YES1 76 9
ABL 98 6
BTK 49 4
JAK2 10 3
SYK 21 2
ZAP70 83 0
TIE2 59 2
BRK 28 8
EPH-A2 92 2
EPH-A4 95 9
EPH-B1 41 6
EPH-B2 108 8
EPH-B3 106 2
EPH-B4 102 2
FGF-R1 53 1
HER4 96 16
IGF-1R 87 6
IR 120 16
IRR 47 0
TrkA 5 0
DDR2 81 20
VEGFR1 17 2
PDGFRA 54 6

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