Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
HG-9-91-01 C32H38ClN7O3 604.14 SIK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91 Download

Results as Barchart

View results as a bar chart
1µM
0.1µM
0.01µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
EPH-B2 1 0
EPH-B1 2 0
FGF-R1 2 0
BRK 3 0
Src 3 1
EPH-B4 5 1
SIK3 5 1
DDR2 6 1
EPH-A2 6 0
EPH-A4 6 2
SIK2 6 5
ABL 7 3
YES1 8 3
RIPK2 8 3
VEGFR1 15 2
PKD1 15 1
TESK1 16 5
PAK2 18 10
EPH-B3 18 1
MINK1 18 1
HER4 18 3
p38 beta MAPK 19 5
BTK 21 7
JNK2 21 2
GCK 21 4
p38 alpha MAPK 26 1
MARK3 28 5
TAO1 33 6
CHK2 34 0
RSK1 38 5
JNK3 38 7
CSK 38 0
MST3 40 13
MLK1 42 6
TIE2 42 12
Lck 47 0
MARK1 53 4
RSK2 54 10
HIPK1 56 5
OSR1 57 4
TSSK1 62 4
MARK2 63 12
NUAK1 64 4
MARK4 67 18
ROCK 2 68 5
Aurora A 70 1
MLK3 70 12
MELK 71 4
PAK5 72 16
HIPK3 74 8
MAPKAP-K3 75 8
PKB beta 75 16
TTK 75 1
MST4 78 8
CK1 delta 79 13
PKA 79 11
TAK1 84 6
MKK2 85 4
JNK1 86 12
BRSK1 86 4
CHK1 86 3
PAK6 88 8
BRSK2 88 4
GSK3 beta 88 6
EF2K 89 5
TrkA 89 3
JAK2 89 8
CAMKK beta 89 7
CAMK1 90 10
IRAK4 90 1
PRK2 90 10
SRPK1 90 11
Aurora B 91 6
PKB alpha 91 10
SmMLCK 91 4
NEK6 91 17
TBK1 91 9
MKK6 92 6
TLK1 93 3
DYRK1A 93 8
SGK1 93 8
DYRK2 93 3
S6K1 93 6
ZAP70 94 9
PAK4 94 12
ERK8 94 14
EIF2AK3 95 7
ERK1 95 0
IRAK1 95 10
NEK2a 95 6
CDK9-Cyclin T1 95 6
LKB1 96 19
AMPK 96 6
DAPK1 96 15
PKC gamma 96 6
MAPKAP-K2 97 3
MKK1 97 19
DYRK3 97 0
PLK1 97 9
p38 delta MAPK 98 1
CK1 gamma 2 99 20
IKK beta 99 16
MEKK1 99 22
CK2 100 6
SYK 100 19
MNK2 102 1
IKK epsilon 102 13
PKC zeta 102 2
WNK1 102 4
PDK1 103 12
PIM3 103 7
PKC alpha 104 6
p38 gamma MAPK 105 2
IR 106 3
MPSK1 106 15
CDK2-Cyclin A 106 3
IRR 107 5
PHK 107 11
STK33 107 9
CLK2 108 5
ERK2 109 15
MSK1 110 21
PIM1 111 8
MNK1 112 15
TTBK1 112 12
HIPK2 114 24
IGF-1R 115 36
PIM2 117 1
MST2 118 5
PRAK 125 3
ASK1 128 39
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
DDR2 8 0
Src 9 2
YES1 11 1
EPH-A4 12 3
SIK2 13 3
EPH-A2 15 0
BRK 24 2
TESK1 29 3
FGF-R1 34 2
PKD1 36 0
SIK3 36 7
RIPK2 37 3
BTK 38 4
ABL 39 5
p38 beta MAPK 42 2
EPH-B2 43 15
EPH-B1 49 8
Lck 54 4
PAK2 59 17
HIPK1 60 12
EPH-B3 61 9
VEGFR1 64 2
HER4 66 21
TAO1 69 0
GCK 72 12
MARK3 73 2
CHK2 75 4
MINK1 76 2
JNK3 77 2
PIM2 79 23
p38 alpha MAPK 79 7
EPH-B4 80 4
MST3 81 33
TIE2 82 14
PKB beta 83 5
SRPK1 85 13
CK1 delta 85 7
DYRK2 85 18
HIPK3 86 10
CDK9-Cyclin T1 87 11
MARK1 87 8
JAK2 88 9
DAPK1 88 19
SmMLCK 89 9
MAPKAP-K3 90 4
CAMK1 90 5
MARK2 90 5
NEK6 90 8
JNK2 90 4
RSK1 91 13
Aurora A 91 15
PAK5 91 8
TBK1 91 8
RSK2 92 1
Aurora B 92 2
PKB alpha 92 8
DYRK3 92 7
TTK 92 2
CK1 gamma 2 93 2
TLK1 93 8
NEK2a 93 5
OSR1 93 4
MELK 93 19
NUAK1 93 0
IKK epsilon 94 2
DYRK1A 95 9
IRAK1 95 3
IKK beta 95 12
MST4 95 16
PDK1 96 8
MKK2 96 0
PKA 96 10
p38 delta MAPK 97 0
MEKK1 97 29
MLK1 97 2
EIF2AK3 97 2
AMPK 97 4
PAK4 97 13
IRAK4 97 5
BRSK2 97 2
ZAP70 98 0
S6K1 99 6
PRK2 99 8
BRSK1 99 4
MLK3 100 8
MAPKAP-K2 100 3
CK2 100 4
TrkA 100 23
CLK2 100 2
CHK1 100 18
CSK 101 5
MKK6 101 9
ERK1 101 17
MARK4 101 7
PAK6 101 8
PLK1 102 6
TSSK1 102 12
CAMKK beta 102 2
PKC alpha 102 7
SGK1 103 26
ROCK 2 103 25
GSK3 beta 103 21
SYK 104 4
PHK 104 2
PKC gamma 104 2
PKC zeta 104 5
MSK1 105 3
STK33 106 4
IR 106 3
MKK1 106 4
LKB1 106 0
MPSK1 106 9
MNK2 107 6
JNK1 107 3
WNK1 107 2
EF2K 108 11
MST2 109 13
PIM3 110 0
TAK1 110 5
ERK2 110 13
p38 gamma MAPK 112 2
ERK8 112 4
IRR 112 11
PIM1 113 14
HIPK2 115 24
PRAK 115 2
MNK1 116 13
TTBK1 117 5
IGF-1R 119 25
ASK1 119 11
CDK2-Cyclin A 121 5
Screening Concentration: 0.01µM
Kinase % Activity Remainingsort descending Standard Deviation
DDR2 17 1
YES1 34 2
Src 45 4
EPH-A2 51 4
EPH-B1 62 4
SIK2 62 1
Lck 63 16
HIPK1 69 6
EPH-A4 71 12
RIPK2 77 6
HIPK3 80 3
TESK1 82 5
SIK3 83 0
PKB beta 83 11
IKK beta 83 14
TAO1 85 6
ABL 87 6
PAK2 87 19
MARK1 88 8
S6K1 88 10
CHK2 89 12
p38 beta MAPK 89 6
CK1 delta 89 2
DYRK2 89 6
HER4 90 8
IRAK4 90 7
ROCK 2 90 4
EIF2AK3 91 4
BTK 91 0
PKA 91 17
DYRK3 92 10
MARK3 92 0
JNK3 93 7
Aurora B 93 5
MINK1 94 3
MEKK1 94 15
SGK1 94 7
JNK1 94 8
PAK6 94 2
CHK1 95 3
EF2K 95 30
VEGFR1 95 1
PAK5 95 7
PKD1 96 17
SRPK1 96 3
CK1 gamma 2 96 3
MAPKAP-K3 96 8
ZAP70 96 1
PKC zeta 97 12
NUAK1 97 0
AMPK 97 3
CLK2 97 14
CAMK1 97 11
BRK 97 12
PLK1 98 16
Aurora A 98 10
TLK1 98 4
CK2 98 9
PKB alpha 98 9
TrkA 98 16
IRAK1 98 7
DAPK1 98 21
BRSK2 99 24
JAK2 99 2
SmMLCK 99 13
TTK 100 3
MST4 100 3
WNK1 100 13
RSK2 100 1
TTBK1 100 13
DYRK1A 100 3
PKC gamma 101 4
TBK1 101 1
MLK1 101 5
MAPKAP-K2 101 2
MKK2 101 6
MARK2 101 9
OSR1 101 1
PKC alpha 102 14
p38 delta MAPK 102 0
FGF-R1 102 9
NEK6 102 6
GCK 103 3
PIM3 103 15
ERK2 103 11
JNK2 103 2
BRSK1 103 13
CDK9-Cyclin T1 104 8
MSK1 104 2
ERK1 104 3
MELK 105 4
MST3 105 2
MLK3 105 6
CAMKK beta 105 16
MPSK1 106 2
RSK1 106 10
PRK2 106 25
GSK3 beta 107 29
PIM1 107 6
MNK2 107 10
MKK1 107 1
EPH-B3 108 5
ERK8 108 16
TSSK1 108 0
LKB1 108 10
EPH-B2 109 10
PIM2 109 36
MNK1 109 4
p38 gamma MAPK 110 1
EPH-B4 110 4
ASK1 110 16
MKK6 110 22
IKK epsilon 112 25
MST2 112 6
PDK1 112 10
SYK 112 10
NEK2a 112 4
STK33 113 6
IRR 113 6
IR 115 10
TIE2 116 8
PAK4 116 2
CSK 119 2
HIPK2 119 29
PRAK 119 6
CDK2-Cyclin A 120 12
IGF-1R 120 38
MARK4 120 6
p38 alpha MAPK 121 8
TAK1 121 21
PHK 125 2

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