Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
HG-9-91-01 C32H38ClN7O3 604.14 SIK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91 Download

Results as Barchart

View results as a bar chart
1µM
0.1µM
0.01µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 106 4
MKK2 96 0
MKK6 101 9
ERK1 101 17
ERK2 110 13
JNK1 107 3
JNK2 90 4
JNK3 77 2
p38 alpha MAPK 79 7
p38 beta MAPK 42 2
p38 gamma MAPK 112 2
p38 delta MAPK 97 0
ERK8 112 4
RSK1 91 13
RSK2 92 1
PDK1 96 8
PKB alpha 92 8
PKB beta 83 5
SGK1 103 26
S6K1 99 6
PKA 96 10
ROCK 2 103 25
PRK2 99 8
PKC alpha 102 7
PKC gamma 104 2
PKC zeta 104 5
PKD1 36 0
STK33 106 4
MSK1 105 3
MNK1 116 13
MNK2 107 6
MAPKAP-K2 100 3
MAPKAP-K3 90 4
PRAK 115 2
CAMKK beta 102 2
CAMK1 90 5
SmMLCK 89 9
PHK 104 2
DAPK1 88 19
CHK1 100 18
CHK2 75 4
GSK3 beta 103 21
CDK2-Cyclin A 121 5
CDK9-Cyclin T1 87 11
PLK1 102 6
Aurora A 91 15
Aurora B 92 2
TLK1 93 8
LKB1 106 0
AMPK 97 4
MARK1 87 8
MARK2 90 5
MARK3 73 2
MARK4 101 7
BRSK1 99 4
BRSK2 97 2
MELK 93 19
NUAK1 93 0
SIK2 13 3
SIK3 36 7
TSSK1 102 12
CK1 gamma 2 93 2
CK1 delta 85 7
CK2 100 4
TTBK1 117 5
DYRK1A 95 9
DYRK2 85 18
DYRK3 92 7
NEK2a 93 5
NEK6 90 8
IKK beta 95 12
IKK epsilon 94 2
TBK1 91 8
PIM1 113 14
PIM2 79 23
PIM3 110 0
SRPK1 85 13
EF2K 108 11
EIF2AK3 97 2
HIPK1 60 12
HIPK2 115 24
HIPK3 86 10
CLK2 100 2
PAK2 59 17
PAK4 97 13
PAK5 91 8
PAK6 101 8
MST2 109 13
MST3 81 33
MST4 95 16
GCK 72 12
MINK1 76 2
MEKK1 97 29
MLK1 97 2
MLK3 100 8
TESK1 29 3
TAO1 69 0
ASK1 119 11
TAK1 110 5
IRAK1 95 3
IRAK4 97 5
RIPK2 37 3
OSR1 93 4
TTK 92 2
MPSK1 106 9
WNK1 107 2
Src 9 2
Lck 54 4
CSK 101 5
YES1 11 1
ABL 39 5
BTK 38 4
JAK2 88 9
SYK 104 4
ZAP70 98 0
TIE2 82 14
BRK 24 2
EPH-A2 15 0
EPH-A4 12 3
EPH-B1 49 8
EPH-B2 43 15
EPH-B3 61 9
EPH-B4 80 4
FGF-R1 34 2
HER4 66 21
IGF-1R 119 25
IR 106 3
IRR 112 11
TrkA 100 23
DDR2 8 0
VEGFR1 64 2
Screening Concentration: 0.01µM
Kinase % Activity Remaining Standard Deviation
MKK1 107 1
MKK2 101 6
MKK6 110 22
ERK1 104 3
ERK2 103 11
JNK1 94 8
JNK2 103 2
JNK3 93 7
p38 alpha MAPK 121 8
p38 beta MAPK 89 6
p38 gamma MAPK 110 1
p38 delta MAPK 102 0
ERK8 108 16
RSK1 106 10
RSK2 100 1
PDK1 112 10
PKB alpha 98 9
PKB beta 83 11
SGK1 94 7
S6K1 88 10
PKA 91 17
ROCK 2 90 4
PRK2 106 25
PKC alpha 102 14
PKC gamma 101 4
PKC zeta 97 12
PKD1 96 17
STK33 113 6
MSK1 104 2
MNK1 109 4
MNK2 107 10
MAPKAP-K2 101 2
MAPKAP-K3 96 8
PRAK 119 6
CAMKK beta 105 16
CAMK1 97 11
SmMLCK 99 13
PHK 125 2
DAPK1 98 21
CHK1 95 3
CHK2 89 12
GSK3 beta 107 29
CDK2-Cyclin A 120 12
CDK9-Cyclin T1 104 8
PLK1 98 16
Aurora A 98 10
Aurora B 93 5
TLK1 98 4
LKB1 108 10
AMPK 97 3
MARK1 88 8
MARK2 101 9
MARK3 92 0
MARK4 120 6
BRSK1 103 13
BRSK2 99 24
MELK 105 4
NUAK1 97 0
SIK2 62 1
SIK3 83 0
TSSK1 108 0
CK1 gamma 2 96 3
CK1 delta 89 2
CK2 98 9
TTBK1 100 13
DYRK1A 100 3
DYRK2 89 6
DYRK3 92 10
NEK2a 112 4
NEK6 102 6
IKK beta 83 14
IKK epsilon 112 25
TBK1 101 1
PIM1 107 6
PIM2 109 36
PIM3 103 15
SRPK1 96 3
EF2K 95 30
EIF2AK3 91 4
HIPK1 69 6
HIPK2 119 29
HIPK3 80 3
CLK2 97 14
PAK2 87 19
PAK4 116 2
PAK5 95 7
PAK6 94 2
MST2 112 6
MST3 105 2
MST4 100 3
GCK 103 3
MINK1 94 3
MEKK1 94 15
MLK1 101 5
MLK3 105 6
TESK1 82 5
TAO1 85 6
ASK1 110 16
TAK1 121 21
IRAK1 98 7
IRAK4 90 7
RIPK2 77 6
OSR1 101 1
TTK 100 3
MPSK1 106 2
WNK1 100 13
Src 45 4
Lck 63 16
CSK 119 2
YES1 34 2
ABL 87 6
BTK 91 0
JAK2 99 2
SYK 112 10
ZAP70 96 1
TIE2 116 8
BRK 97 12
EPH-A2 51 4
EPH-A4 71 12
EPH-B1 62 4
EPH-B2 109 10
EPH-B3 108 5
EPH-B4 110 4
FGF-R1 102 9
HER4 90 8
IGF-1R 120 38
IR 115 10
IRR 113 6
TrkA 98 16
DDR2 17 1
VEGFR1 95 1
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 97 19
MKK2 85 4
MKK6 92 6
ERK1 95 0
ERK2 109 15
JNK1 86 12
JNK2 21 2
JNK3 38 7
p38 alpha MAPK 26 1
p38 beta MAPK 19 5
p38 gamma MAPK 105 2
p38 delta MAPK 98 1
ERK8 94 14
RSK1 38 5
RSK2 54 10
PDK1 103 12
PKB alpha 91 10
PKB beta 75 16
SGK1 93 8
S6K1 93 6
PKA 79 11
ROCK 2 68 5
PRK2 90 10
PKC alpha 104 6
PKC gamma 96 6
PKC zeta 102 2
PKD1 15 1
STK33 107 9
MSK1 110 21
MNK1 112 15
MNK2 102 1
MAPKAP-K2 97 3
MAPKAP-K3 75 8
PRAK 125 3
CAMKK beta 89 7
CAMK1 90 10
SmMLCK 91 4
PHK 107 11
DAPK1 96 15
CHK1 86 3
CHK2 34 0
GSK3 beta 88 6
CDK2-Cyclin A 106 3
CDK9-Cyclin T1 95 6
PLK1 97 9
Aurora A 70 1
Aurora B 91 6
TLK1 93 3
LKB1 96 19
AMPK 96 6
MARK1 53 4
MARK2 63 12
MARK3 28 5
MARK4 67 18
BRSK1 86 4
BRSK2 88 4
MELK 71 4
NUAK1 64 4
SIK2 6 5
SIK3 5 1
TSSK1 62 4
CK1 gamma 2 99 20
CK1 delta 79 13
CK2 100 6
TTBK1 112 12
DYRK1A 93 8
DYRK2 93 3
DYRK3 97 0
NEK2a 95 6
NEK6 91 17
IKK beta 99 16
IKK epsilon 102 13
TBK1 91 9
PIM1 111 8
PIM2 117 1
PIM3 103 7
SRPK1 90 11
EF2K 89 5
EIF2AK3 95 7
HIPK1 56 5
HIPK2 114 24
HIPK3 74 8
CLK2 108 5
PAK2 18 10
PAK4 94 12
PAK5 72 16
PAK6 88 8
MST2 118 5
MST3 40 13
MST4 78 8
GCK 21 4
MINK1 18 1
MEKK1 99 22
MLK1 42 6
MLK3 70 12
TESK1 16 5
TAO1 33 6
ASK1 128 39
TAK1 84 6
IRAK1 95 10
IRAK4 90 1
RIPK2 8 3
OSR1 57 4
TTK 75 1
MPSK1 106 15
WNK1 102 4
Src 3 1
Lck 47 0
CSK 38 0
YES1 8 3
ABL 7 3
BTK 21 7
JAK2 89 8
SYK 100 19
ZAP70 94 9
TIE2 42 12
BRK 3 0
EPH-A2 6 0
EPH-A4 6 2
EPH-B1 2 0
EPH-B2 1 0
EPH-B3 18 1
EPH-B4 5 1
FGF-R1 2 0
HER4 18 3
IGF-1R 115 36
IR 106 3
IRR 107 5
TrkA 89 3
DDR2 6 1
VEGFR1 15 2

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