Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Parthenolide C15H20O3 248.32 IKKβ Kwok B.H. (2001) Chem. Biol. 8 759-766 Sigma Download

Results as Barchart

View results as a bar chart
5µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 96 5
MKK2 114 35
MKK6 96 10
ERK1 105 8
ERK2 90 9
JNK1 104 3
JNK2 114 5
JNK3 115 1
p38 alpha MAPK 105 3
p38 beta MAPK 111 0
p38 gamma MAPK 108 3
p38 delta MAPK 115 12
ERK8 98 4
RSK1 110 9
RSK2 102 5
PDK1 114 12
PKB alpha 107 15
PKB beta 101 15
SGK1 127 20
S6K1 103 8
PKA 121 4
ROCK 2 123 3
PRK2 106 0
PKC alpha 108 2
PKC gamma 120 9
PKC zeta 117 10
PKD1 130 12
STK33 117 5
MSK1 110 3
MNK1 116 1
MNK2 113 6
MAPKAP-K2 72 19
MAPKAP-K3 135 18
PRAK 131 27
CAMKK beta 96 24
CAMK1 116 17
SmMLCK 123 9
PHK 116 3
DAPK1 102 2
CHK1 123 10
CHK2 102 19
GSK3 beta 106 13
CDK2-Cyclin A 93 6
CDK9-Cyclin T1 119 12
PLK1 103 6
Aurora A 134 21
Aurora B 106 5
TLK1 108 4
LKB1 132 12
AMPK 97 5
AMPK (hum) 111 5
MARK1 100 12
MARK2 112 2
MARK3 123 0
MARK4 111 9
BRSK1 109 3
BRSK2 109 13
MELK 138 9
NUAK1 130 1
SIK2 108 3
SIK3 110 6
TSSK1 103 4
CK1 gamma 2 124 11
CK1 delta 99 3
CK2 117 7
TTBK1 110 8
TTBK2 125 10
DYRK1A 120 7
DYRK2 113 5
DYRK3 124 1
NEK2a 110 11
NEK6 113 7
IKK beta 94 20
IKK epsilon 112 3
TBK1 104 7
PIM1 97 4
PIM2 110 3
PIM3 119 7
SRPK1 111 2
EF2K 107 7
EIF2AK3 111 9
HIPK1 114 1
HIPK2 124 13
HIPK3 110 12
CLK2 90 5
PAK2 102 14
PAK4 93 11
PAK5 117 2
PAK6 119 7
MST2 118 1
MST3 101 12
MST4 88 7
GCK 116 3
MAP4K3 95 3
MAP4K5 116 10
MINK1 108 3
MEKK1 112 6
MLK1 117 11
MLK3 104 5
TESK1 106 10
TAO1 118 21
ASK1 98 16
TAK1 109 2
IRAK1 96 1
IRAK4 106 10
RIPK2 101 2
OSR1 115 5
TTK 109 9
MPSK1 121 16
WNK1 112 2
ULK1 104 0
ULK2 96 5
Src 110 0
Lck 112 3
CSK 130 23
YES1 125 31
ABL 119 1
BTK 117 12
JAK2 116 0
SYK 102 11
ZAP70 99 5
TIE2 99 9
BRK 107 4
EPH-A2 104 4
EPH-A4 110 3
EPH-B1 103 4
EPH-B2 72 4
EPH-B3 95 6
EPH-B4 124 2
FGF-R1 106 1
HER4 98 17
IGF-1R 120 8
IR 117 22
IRR 107 1
TrkA 106 8
DDR2 105 4
VEGFR1 109 2
PDGFRA 105 36
Screening Concentration: 5µM
Kinase % Activity Remaining Standard Deviation
MKK1 93 1
MKK2 109 1
MKK6 92 12
ERK1 103 4
ERK2 83 19
JNK1 102 10
JNK2 110 2
JNK3 134 8
p38 alpha MAPK 111 18
p38 beta MAPK 121 7
p38 gamma MAPK 115 7
p38 delta MAPK 113 13
ERK8 119 12
RSK1 112 1
RSK2 94 0
PDK1 98 3
PKB alpha 106 12
PKB beta 92 8
SGK1 115 12
S6K1 106 2
PKA 103 2
ROCK 2 113 1
PRK2 102 9
PKC alpha 108 12
PKC gamma 121 4
PKC zeta 98 2
PKD1 108 10
STK33 102 4
MSK1 106 13
MNK1 94 1
MNK2 117 5
MAPKAP-K2 64 11
MAPKAP-K3 58 11
PRAK 112 22
CAMKK beta 84 32
CAMK1 104 1
SmMLCK 113 4
PHK 108 2
DAPK1 107 13
CHK1 98 1
CHK2 121 7
GSK3 beta 105 11
CDK2-Cyclin A 116 12
CDK9-Cyclin T1 101 17
PLK1 103 2
Aurora A 115 13
Aurora B 99 11
TLK1 115 8
LKB1 106 3
AMPK 98 1
AMPK (hum) 107 4
MARK1 94 8
MARK2 102 6
MARK3 98 14
MARK4 93 5
BRSK1 108 5
BRSK2 89 20
MELK 100 3
NUAK1 111 3
SIK2 93 12
SIK3 104 7
TSSK1 93 7
CK1 gamma 2 101 8
CK1 delta 92 21
CK2 106 15
TTBK1 103 2
TTBK2 100 12
DYRK1A 101 9
DYRK2 101 2
DYRK3 106 1
NEK2a 122 23
NEK6 82 2
IKK beta 69 31
IKK epsilon 108 9
TBK1 132 32
PIM1 108 6
PIM2 102 7
PIM3 121 7
SRPK1 106 10
EF2K 91 15
EIF2AK3 123 6
HIPK1 106 16
HIPK2 113 10
HIPK3 122 6
CLK2 93 2
PAK2 103 6
PAK4 104 2
PAK5 98 7
PAK6 115 14
MST2 125 14
MST3 88 7
MST4 94 17
GCK 98 12
MAP4K3 88 8
MAP4K5 97 4
MINK1 122 11
MEKK1 120 0
MLK1 95 5
MLK3 116 7
TESK1 112 10
TAO1 103 7
ASK1 125 13
TAK1 116 22
IRAK1 102 11
IRAK4 97 5
RIPK2 112 4
OSR1 118 25
TTK 106 3
MPSK1 106 5
WNK1 100 5
ULK1 110 5
ULK2 121 1
Src 111 2
Lck 114 21
CSK 98 2
YES1 109 9
ABL 110 1
BTK 85 9
JAK2 98 3
SYK 105 3
ZAP70 104 3
TIE2 80 9
BRK 120 12
EPH-A2 99 1
EPH-A4 87 4
EPH-B1 115 6
EPH-B2 78 6
EPH-B3 115 2
EPH-B4 114 20
FGF-R1 99 13
HER4 90 11
IGF-1R 109 10
IR 106 30
IRR 95 3
TrkA 83 3
DDR2 107 5
VEGFR1 98 5
PDGFRA 109 1

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