Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Withaferin A C28H38O6 470.6 IKKβ Kaileh (2007) J.Biol.Chem. 282 4253 Tocris Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
Aurora B 10 1
PKB beta 10 1
CAMK1 30 1
VEGFR1 30 8
Aurora A 30 2
MAPKAP-K3 47 11
HIPK3 58 7
HIPK2 60 2
CHK2 61 10
IKK epsilon 61 7
SRPK1 63 8
MAPKAP-K2 63 25
SIK2 66 5
YES1 68 24
GCK 68 9
S6K1 69 3
IKK beta 72 9
ERK8 72 10
RSK2 74 12
IRR 77 2
MARK4 77 8
BRSK2 77 0
DYRK3 78 11
TSSK1 78 3
IRAK4 79 7
MST4 80 21
MINK1 81 2
NEK2a 82 4
TIE2 83 17
PIM3 83 1
MAP4K3 84 0
PAK2 86 11
MLK1 86 17
ULK2 90 7
AMPK 90 2
BRSK1 91 4
p38 delta MAPK 92 4
TBK1 93 9
Src 93 21
CLK2 94 3
DDR2 94 1
PIM1 94 9
TTK 94 4
SIK3 94 8
MAP4K5 94 4
CK2 94 1
FGF-R1 94 6
p38 alpha MAPK 95 2
MEKK1 95 14
TTBK1 95 2
PKC alpha 96 11
EPH-A2 96 5
MLK3 97 4
TrkA 97 13
PIM2 97 6
EF2K 97 9
EPH-B3 97 11
TLK1 98 13
CAMKK beta 99 16
MSK1 99 10
DYRK1A 100 3
IRAK1 100 1
HER4 101 0
PKC zeta 101 5
HIPK1 101 2
PKC gamma 102 4
SGK1 103 19
JAK2 103 6
p38 gamma MAPK 103 2
CK1 gamma 2 103 7
TESK1 104 6
DYRK2 104 15
PRK2 104 2
PAK4 104 11
PKD1 104 17
PHK 105 5
PAK6 105 5
RSK1 105 2
EPH-B2 105 10
CK1 delta 105 5
PKB alpha 105 3
EPH-B4 105 2
PRAK 105 24
ABL 106 8
CDK9-Cyclin T1 107 9
EPH-B1 107 5
DAPK1 108 12
MNK1 108 1
MKK6 109 0
ERK1 109 14
TAK1 109 16
EPH-A4 109 4
JNK1 110 0
BTK 110 9
RIPK2 110 9
NUAK1 110 5
CSK 111 10
MARK1 111 3
ERK2 111 9
NEK6 111 7
PAK5 111 10
ULK1 111 0
MKK1 111 7
AMPK (hum) 112 9
TTBK2 112 10
ROCK 2 112 2
IGF-1R 113 6
PKA 113 5
WNK1 113 5
SmMLCK 114 6
LKB1 114 6
BRK 115 20
EIF2AK3 115 1
PDK1 116 14
CHK1 117 7
CDK2-Cyclin A 117 7
MARK2 118 7
MARK3 118 7
ASK1 118 21
PLK1 118 17
JNK2 119 7
TAO1 120 10
STK33 120 11
MKK2 120 2
PDGFRA 121 12
MELK 123 1
ZAP70 124 36
OSR1 125 10
MPSK1 126 4
MNK2 126 13
GSK3 beta 127 12
IR 128 33
p38 beta MAPK 128 7
MST2 129 1
Lck 129 15
SYK 130 15
MST3 133 8
JNK3 136 3
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
TBK1 48 23
MAPKAP-K2 50 21
CK2 79 6
MAP4K3 81 14
SIK2 82 13
MARK4 87 2
CLK2 88 8
SRPK1 89 7
MLK1 91 13
PKB beta 92 16
DYRK1A 92 1
CAMK1 92 13
TrkA 92 18
CK1 delta 92 3
ULK2 92 7
NEK2a 93 2
TIE2 93 20
PAK4 94 11
EPH-A2 94 7
CDK9-Cyclin T1 94 0
MINK1 94 5
MKK6 95 13
NEK6 95 23
RIPK2 95 8
PIM3 95 2
HIPK3 96 14
PKC alpha 96 11
IKK epsilon 96 2
PIM2 96 0
DYRK2 97 4
IRAK4 97 23
MST4 97 0
FGF-R1 98 0
JAK2 98 4
MELK 98 2
GCK 98 3
MNK1 98 3
AMPK 99 1
YES1 99 4
S6K1 99 7
IRR 99 11
ERK1 99 3
BRSK2 99 9
MARK3 99 3
MNK2 99 12
TTBK1 100 5
MKK1 100 10
PAK2 100 9
ERK2 100 29
TSSK1 100 1
ABL 101 4
IRAK1 101 2
p38 alpha MAPK 101 11
TLK1 101 7
PAK5 102 6
TAO1 103 14
DYRK3 103 6
ROCK 2 103 6
JNK1 103 0
PRK2 103 5
IKK beta 103 4
PKC zeta 103 3
LKB1 104 5
Lck 104 26
ASK1 104 12
MSK1 104 17
EF2K 104 5
PRAK 105 21
IGF-1R 105 1
DDR2 105 5
SIK3 105 15
PLK1 105 9
EPH-B1 105 4
MARK1 106 3
BRSK1 106 3
p38 delta MAPK 106 6
MAP4K5 106 12
PDK1 107 8
AMPK (hum) 107 0
EPH-A4 107 12
ERK8 107 20
TTBK2 108 10
HIPK2 108 8
MKK2 108 11
DAPK1 108 9
CDK2-Cyclin A 108 6
Aurora A 108 2
ULK1 108 17
Aurora B 108 9
TESK1 109 2
MARK2 109 4
CHK1 109 9
BRK 109 5
PIM1 109 12
PKD1 109 14
CK1 gamma 2 109 3
RSK1 109 8
HIPK1 110 9
MLK3 110 3
SGK1 110 8
PHK 110 4
MST3 111 4
TTK 111 1
CSK 112 3
PKA 112 4
JNK2 112 7
NUAK1 112 3
MEKK1 112 1
HER4 113 13
IR 113 22
SmMLCK 113 13
TAK1 114 17
ZAP70 114 24
GSK3 beta 114 10
p38 gamma MAPK 114 6
EPH-B3 114 2
RSK2 114 18
Src 114 7
CAMKK beta 115 11
STK33 116 1
EPH-B2 116 1
MPSK1 117 22
WNK1 117 2
PKB alpha 118 14
BTK 118 3
PDGFRA 119 30
PKC gamma 119 18
MAPKAP-K3 120 5
VEGFR1 120 18
EPH-B4 120 12
p38 beta MAPK 121 14
JNK3 122 11
MST2 123 2
PAK6 125 3
OSR1 128 0
EIF2AK3 129 15
CHK2 130 12
SYK 155 61
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
MAPKAP-K2 56 15
PKB beta 72 8
SIK2 78 5
CAMK1 84 5
MAP4K3 85 5
MAPKAP-K3 85 15
Aurora B 86 7
SRPK1 86 1
MINK1 88 8
DYRK2 88 8
VEGFR1 91 20
p38 alpha MAPK 92 10
EPH-A2 93 4
CK2 94 8
DYRK1A 94 4
HIPK3 94 3
NEK2a 94 1
MST4 95 15
PRK2 95 4
DAPK1 95 6
ULK2 96 14
PAK2 96 1
IKK epsilon 97 3
CDK9-Cyclin T1 97 1
FGF-R1 97 2
S6K1 97 1
IRR 97 1
MARK4 97 2
TIE2 98 7
EPH-A4 98 6
RSK2 98 4
ERK2 98 24
JAK2 98 10
PKB alpha 99 0
IRAK1 99 11
MNK1 100 6
EF2K 100 4
AMPK 100 5
MLK1 100 5
ERK1 100 2
ASK1 100 13
DDR2 100 6
IRAK4 101 7
MSK1 101 3
PLK1 101 15
RSK1 101 4
EPH-B1 101 1
DYRK3 101 9
PIM2 102 10
Aurora A 102 6
TSSK1 102 13
EPH-B2 102 1
CLK2 102 9
JNK1 102 4
NEK6 102 1
BRSK2 103 2
IKK beta 103 6
PKD1 103 11
PIM1 103 1
TLK1 103 2
CK1 delta 103 9
MNK2 104 24
CK1 gamma 2 104 10
PDK1 104 2
EPH-B3 104 13
PAK4 104 6
TAK1 104 7
TTBK2 105 5
SIK3 106 3
GCK 106 4
MELK 107 4
TBK1 107 1
MKK6 107 20
ROCK 2 107 8
RIPK2 108 5
EIF2AK3 108 4
PRAK 108 30
OSR1 109 6
CSK 109 4
HER4 109 3
PKA 109 9
PKC zeta 110 1
p38 delta MAPK 110 1
PIM3 110 3
MAP4K5 110 5
SGK1 110 20
MLK3 110 2
ABL 110 1
TrkA 110 2
WNK1 111 2
LKB1 111 8
Lck 111 15
MARK2 111 6
PKC alpha 111 15
BRSK1 111 2
PKC gamma 112 1
STK33 112 22
TTK 112 10
HIPK1 112 8
YES1 112 12
PHK 112 3
ZAP70 113 19
CDK2-Cyclin A 113 18
MKK1 113 21
Src 113 8
HIPK2 113 12
TAO1 113 3
TESK1 114 9
SmMLCK 114 16
MARK3 114 17
JNK2 114 4
CHK1 114 9
ERK8 115 19
ULK1 115 7
MEKK1 115 9
CAMKK beta 115 15
MARK1 115 8
BTK 115 12
SYK 115 6
CHK2 116 1
p38 gamma MAPK 116 3
PAK5 116 1
PDGFRA 117 2
MPSK1 117 21
IR 117 12
TTBK1 118 3
EPH-B4 119 6
AMPK (hum) 120 10
NUAK1 121 12
BRK 123 7
IGF-1R 123 0
GSK3 beta 124 5
JNK3 125 3
PAK6 126 2
MST2 126 3
MST3 126 10
MKK2 126 27
p38 beta MAPK 129 20

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