Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Withaferin A C28H38O6 470.6 IKKβ Kaileh (2007) J.Biol.Chem. 282 4253 Tocris Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 111 7
MKK2 120 2
MKK6 109 0
ERK1 109 14
ERK2 111 9
JNK1 110 0
JNK2 119 7
JNK3 136 3
p38 alpha MAPK 95 2
p38 beta MAPK 128 7
p38 gamma MAPK 103 2
p38 delta MAPK 92 4
ERK8 72 10
RSK1 105 2
RSK2 74 12
PDK1 116 14
PKB alpha 105 3
PKB beta 10 1
SGK1 103 19
S6K1 69 3
PKA 113 5
ROCK 2 112 2
PRK2 104 2
PKC alpha 96 11
PKC gamma 102 4
PKC zeta 101 5
PKD1 104 17
STK33 120 11
MSK1 99 10
MNK1 108 1
MNK2 126 13
MAPKAP-K2 63 25
MAPKAP-K3 47 11
PRAK 105 24
CAMKK beta 99 16
CAMK1 30 1
SmMLCK 114 6
PHK 105 5
DAPK1 108 12
CHK1 117 7
CHK2 61 10
GSK3 beta 127 12
CDK2-Cyclin A 117 7
CDK9-Cyclin T1 107 9
PLK1 118 17
Aurora A 30 2
Aurora B 10 1
TLK1 98 13
LKB1 114 6
AMPK 90 2
AMPK (hum) 112 9
MARK1 111 3
MARK2 118 7
MARK3 118 7
MARK4 77 8
BRSK1 91 4
BRSK2 77 0
MELK 123 1
NUAK1 110 5
SIK2 66 5
SIK3 94 8
TSSK1 78 3
CK1 gamma 2 103 7
CK1 delta 105 5
CK2 94 1
TTBK1 95 2
TTBK2 112 10
DYRK1A 100 3
DYRK2 104 15
DYRK3 78 11
NEK2a 82 4
NEK6 111 7
IKK beta 72 9
IKK epsilon 61 7
TBK1 93 9
PIM1 94 9
PIM2 97 6
PIM3 83 1
SRPK1 63 8
EF2K 97 9
EIF2AK3 115 1
HIPK1 101 2
HIPK2 60 2
HIPK3 58 7
CLK2 94 3
PAK2 86 11
PAK4 104 11
PAK5 111 10
PAK6 105 5
MST2 129 1
MST3 133 8
MST4 80 21
GCK 68 9
MAP4K3 84 0
MAP4K5 94 4
MINK1 81 2
MEKK1 95 14
MLK1 86 17
MLK3 97 4
TESK1 104 6
TAO1 120 10
ASK1 118 21
TAK1 109 16
IRAK1 100 1
IRAK4 79 7
RIPK2 110 9
OSR1 125 10
TTK 94 4
MPSK1 126 4
WNK1 113 5
ULK1 111 0
ULK2 90 7
Src 93 21
Lck 129 15
CSK 111 10
YES1 68 24
ABL 106 8
BTK 110 9
JAK2 103 6
SYK 130 15
ZAP70 124 36
TIE2 83 17
BRK 115 20
EPH-A2 96 5
EPH-A4 109 4
EPH-B1 107 5
EPH-B2 105 10
EPH-B3 97 11
EPH-B4 105 2
FGF-R1 94 6
HER4 101 0
IGF-1R 113 6
IR 128 33
IRR 77 2
TrkA 97 13
DDR2 94 1
VEGFR1 30 8
PDGFRA 121 12
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 100 10
MKK2 108 11
MKK6 95 13
ERK1 99 3
ERK2 100 29
JNK1 103 0
JNK2 112 7
JNK3 122 11
p38 alpha MAPK 101 11
p38 beta MAPK 121 14
p38 gamma MAPK 114 6
p38 delta MAPK 106 6
ERK8 107 20
RSK1 109 8
RSK2 114 18
PDK1 107 8
PKB alpha 118 14
PKB beta 92 16
SGK1 110 8
S6K1 99 7
PKA 112 4
ROCK 2 103 6
PRK2 103 5
PKC alpha 96 11
PKC gamma 119 18
PKC zeta 103 3
PKD1 109 14
STK33 116 1
MSK1 104 17
MNK1 98 3
MNK2 99 12
MAPKAP-K2 50 21
MAPKAP-K3 120 5
PRAK 105 21
CAMKK beta 115 11
CAMK1 92 13
SmMLCK 113 13
PHK 110 4
DAPK1 108 9
CHK1 109 9
CHK2 130 12
GSK3 beta 114 10
CDK2-Cyclin A 108 6
CDK9-Cyclin T1 94 0
PLK1 105 9
Aurora A 108 2
Aurora B 108 9
TLK1 101 7
LKB1 104 5
AMPK 99 1
AMPK (hum) 107 0
MARK1 106 3
MARK2 109 4
MARK3 99 3
MARK4 87 2
BRSK1 106 3
BRSK2 99 9
MELK 98 2
NUAK1 112 3
SIK2 82 13
SIK3 105 15
TSSK1 100 1
CK1 gamma 2 109 3
CK1 delta 92 3
CK2 79 6
TTBK1 100 5
TTBK2 108 10
DYRK1A 92 1
DYRK2 97 4
DYRK3 103 6
NEK2a 93 2
NEK6 95 23
IKK beta 103 4
IKK epsilon 96 2
TBK1 48 23
PIM1 109 12
PIM2 96 0
PIM3 95 2
SRPK1 89 7
EF2K 104 5
EIF2AK3 129 15
HIPK1 110 9
HIPK2 108 8
HIPK3 96 14
CLK2 88 8
PAK2 100 9
PAK4 94 11
PAK5 102 6
PAK6 125 3
MST2 123 2
MST3 111 4
MST4 97 0
GCK 98 3
MAP4K3 81 14
MAP4K5 106 12
MINK1 94 5
MEKK1 112 1
MLK1 91 13
MLK3 110 3
TESK1 109 2
TAO1 103 14
ASK1 104 12
TAK1 114 17
IRAK1 101 2
IRAK4 97 23
RIPK2 95 8
OSR1 128 0
TTK 111 1
MPSK1 117 22
WNK1 117 2
ULK1 108 17
ULK2 92 7
Src 114 7
Lck 104 26
CSK 112 3
YES1 99 4
ABL 101 4
BTK 118 3
JAK2 98 4
SYK 155 61
ZAP70 114 24
TIE2 93 20
BRK 109 5
EPH-A2 94 7
EPH-A4 107 12
EPH-B1 105 4
EPH-B2 116 1
EPH-B3 114 2
EPH-B4 120 12
FGF-R1 98 0
HER4 113 13
IGF-1R 105 1
IR 113 22
IRR 99 11
TrkA 92 18
DDR2 105 5
VEGFR1 120 18
PDGFRA 119 30
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 113 21
MKK2 126 27
MKK6 107 20
ERK1 100 2
ERK2 98 24
JNK1 102 4
JNK2 114 4
JNK3 125 3
p38 alpha MAPK 92 10
p38 beta MAPK 129 20
p38 gamma MAPK 116 3
p38 delta MAPK 110 1
ERK8 115 19
RSK1 101 4
RSK2 98 4
PDK1 104 2
PKB alpha 99 0
PKB beta 72 8
SGK1 110 20
S6K1 97 1
PKA 109 9
ROCK 2 107 8
PRK2 95 4
PKC alpha 111 15
PKC gamma 112 1
PKC zeta 110 1
PKD1 103 11
STK33 112 22
MSK1 101 3
MNK1 100 6
MNK2 104 24
MAPKAP-K2 56 15
MAPKAP-K3 85 15
PRAK 108 30
CAMKK beta 115 15
CAMK1 84 5
SmMLCK 114 16
PHK 112 3
DAPK1 95 6
CHK1 114 9
CHK2 116 1
GSK3 beta 124 5
CDK2-Cyclin A 113 18
CDK9-Cyclin T1 97 1
PLK1 101 15
Aurora A 102 6
Aurora B 86 7
TLK1 103 2
LKB1 111 8
AMPK 100 5
AMPK (hum) 120 10
MARK1 115 8
MARK2 111 6
MARK3 114 17
MARK4 97 2
BRSK1 111 2
BRSK2 103 2
MELK 107 4
NUAK1 121 12
SIK2 78 5
SIK3 106 3
TSSK1 102 13
CK1 gamma 2 104 10
CK1 delta 103 9
CK2 94 8
TTBK1 118 3
TTBK2 105 5
DYRK1A 94 4
DYRK2 88 8
DYRK3 101 9
NEK2a 94 1
NEK6 102 1
IKK beta 103 6
IKK epsilon 97 3
TBK1 107 1
PIM1 103 1
PIM2 102 10
PIM3 110 3
SRPK1 86 1
EF2K 100 4
EIF2AK3 108 4
HIPK1 112 8
HIPK2 113 12
HIPK3 94 3
CLK2 102 9
PAK2 96 1
PAK4 104 6
PAK5 116 1
PAK6 126 2
MST2 126 3
MST3 126 10
MST4 95 15
GCK 106 4
MAP4K3 85 5
MAP4K5 110 5
MINK1 88 8
MEKK1 115 9
MLK1 100 5
MLK3 110 2
TESK1 114 9
TAO1 113 3
ASK1 100 13
TAK1 104 7
IRAK1 99 11
IRAK4 101 7
RIPK2 108 5
OSR1 109 6
TTK 112 10
MPSK1 117 21
WNK1 111 2
ULK1 115 7
ULK2 96 14
Src 113 8
Lck 111 15
CSK 109 4
YES1 112 12
ABL 110 1
BTK 115 12
JAK2 98 10
SYK 115 6
ZAP70 113 19
TIE2 98 7
BRK 123 7
EPH-A2 93 4
EPH-A4 98 6
EPH-B1 101 1
EPH-B2 102 1
EPH-B3 104 13
EPH-B4 119 6
FGF-R1 97 2
HER4 109 3
IGF-1R 123 0
IR 117 12
IRR 97 1
TrkA 110 2
DDR2 100 6
VEGFR1 91 20
PDGFRA 117 2

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