Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Lenalidomide (Revlimid) C13H13N3O3 259.26 TNF-α Rushworth S.A. (2013) Cellular Signalling 25 1 106-112 Selleck Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 90 7
MKK2 83 2
MKK6 93 2
ERK1 90 10
ERK2 104 27
ERK5 98 9
JNK1 99 11
JNK2 100 16
JNK3 90 0
p38 alpha MAPK 105 4
p38 beta MAPK 96 6
p38 gamma MAPK 109 8
p38 delta MAPK 109 11
ERK8 92 9
RSK1 98 1
RSK2 93 2
PDK1 91 21
PKB alpha 88 3
PKB beta 85 9
SGK1 91 10
S6K1 94 10
PKA 101 16
ROCK 2 90 8
PRK2 93 8
PKC alpha 107 1
PKC gamma 108 4
PKC zeta 100 16
PKD1 103 7
STK33 128 18
MSK1 91 9
MNK1 116 7
MNK2 80 2
MAPKAP-K2 79 13
MAPKAP-K3 94 5
PRAK 86 12
CAMKK beta 92 7
CAMK1 103 2
SmMLCK 94 9
PHK 101 2
DAPK1 95 12
CHK1 94 3
CHK2 96 12
GSK3 beta 104 20
CDK2-Cyclin A 96 7
CDK9-Cyclin T1 106 52
PLK1 104 8
Aurora A 113 18
Aurora B 83 5
TLK1 95 9
LKB1 116 2
AMPK 98 1
AMPK (hum) 106 0
MARK1 98 6
MARK2 99 0
MARK3 91 11
MARK4 86 22
BRSK1 84 5
BRSK2 98 5
MELK 94 3
NUAK1 99 5
SIK2 83 9
SIK3 91 7
TSSK1 89 17
CK1 gamma 2 99 7
CK1 delta 102 2
CK2 106 5
TTBK1 106 18
TTBK2 93 25
DYRK1A 107 1
DYRK2 101 9
DYRK3 104 8
NEK2a 97 18
NEK6 105 13
IKK beta 100 7
IKK epsilon 119 1
TBK1 95 6
PIM1 93 7
PIM2 98 9
PIM3 101 9
SRPK1 104 5
EF2K 94 7
EIF2AK3 86 8
HIPK1 92 7
HIPK2 107 3
HIPK3 108 35
CLK2 104 12
PAK2 101 6
PAK4 102 0
PAK5 86 7
PAK6 102 12
MST2 102 7
MST3 82 10
MST4 106 3
GCK 103 15
MAP4K3 100 9
MAP4K5 109 2
MINK1 111 6
MEKK1 101 15
MLK1 99 3
MLK3 92 17
TESK1 77 6
TAO1 106 7
ASK1 102 12
TAK1 99 5
IRAK1 96 0
IRAK4 107 4
RIPK2 97 2
OSR1 91 2
TTK 104 5
MPSK1 98 5
WNK1 104 5
ULK1 104 2
ULK2 106 12
TGFBR1 105 19
Src 105 17
Lck 100 6
CSK 87 7
YES1 102 14
ABL 96 14
BTK 104 12
JAK2 103 3
SYK 108 25
ZAP70 110 18
TIE2 85 23
BRK 101 26
EPH-A2 106 35
EPH-A4 110 9
EPH-B1 115 7
EPH-B2 107 15
EPH-B3 98 21
EPH-B4 91 7
FGF-R1 110 21
HER4 105 36
IGF-1R 106 14
IR 103 29
IRR 102 14
TrkA 116 22
DDR2 102 17
VEGFR1 100 1
PDGFRA 85 4
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 92 1
MKK2 81 10
MKK6 100 19
ERK1 94 5
ERK2 101 25
ERK5 107 19
JNK1 106 9
JNK2 102 9
JNK3 95 7
p38 alpha MAPK 103 9
p38 beta MAPK 106 3
p38 gamma MAPK 108 10
p38 delta MAPK 123 6
ERK8 98 3
RSK1 97 4
RSK2 101 8
PDK1 89 7
PKB alpha 91 12
PKB beta 94 7
SGK1 96 23
S6K1 93 0
PKA 84 3
ROCK 2 88 5
PRK2 88 8
PKC alpha 100 7
PKC gamma 112 6
PKC zeta 108 15
PKD1 114 18
STK33 119 11
MSK1 94 24
MNK1 111 10
MNK2 89 1
MAPKAP-K2 92 16
MAPKAP-K3 86 2
PRAK 87 10
CAMKK beta 84 8
CAMK1 91 12
SmMLCK 94 6
PHK 103 3
DAPK1 104 12
CHK1 82 4
CHK2 93 6
GSK3 beta 92 15
CDK2-Cyclin A 87 2
CDK9-Cyclin T1 119 21
PLK1 96 16
Aurora A 100 16
Aurora B 105 9
TLK1 106 13
LKB1 112 7
AMPK 92 5
AMPK (hum) 102 3
MARK1 100 0
MARK2 104 17
MARK3 94 0
MARK4 90 19
BRSK1 94 10
BRSK2 105 7
MELK 90 2
NUAK1 90 22
SIK2 91 0
SIK3 94 10
TSSK1 100 14
CK1 gamma 2 90 1
CK1 delta 97 4
CK2 93 7
TTBK1 118 14
TTBK2 101 8
DYRK1A 99 11
DYRK2 103 14
DYRK3 99 2
NEK2a 96 15
NEK6 96 8
IKK beta 106 4
IKK epsilon 99 2
TBK1 102 7
PIM1 87 1
PIM2 99 21
PIM3 103 12
SRPK1 104 8
EF2K 82 5
EIF2AK3 101 2
HIPK1 101 10
HIPK2 103 16
HIPK3 119 27
CLK2 98 2
PAK2 103 11
PAK4 107 8
PAK5 77 15
PAK6 104 3
MST2 101 1
MST3 84 9
MST4 112 12
GCK 114 0
MAP4K3 110 12
MAP4K5 115 6
MINK1 118 2
MEKK1 97 5
MLK1 99 2
MLK3 98 9
TESK1 77 4
TAO1 96 0
ASK1 101 3
TAK1 104 9
IRAK1 101 19
IRAK4 110 10
RIPK2 106 0
OSR1 112 4
TTK 118 14
MPSK1 100 3
WNK1 106 3
ULK1 103 3
ULK2 105 0
TGFBR1 115 5
Src 114 8
Lck 99 1
CSK 97 3
YES1 102 11
ABL 101 10
BTK 107 12
JAK2 93 7
SYK 114 17
ZAP70 116 3
TIE2 90 39
BRK 114 7
EPH-A2 96 11
EPH-A4 124 6
EPH-B1 126 12
EPH-B2 113 18
EPH-B3 102 16
EPH-B4 99 15
FGF-R1 109 6
HER4 106 6
IGF-1R 106 8
IR 107 11
IRR 109 8
TrkA 141 7
DDR2 102 4
VEGFR1 110 12
PDGFRA 82 2

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