Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Dimethyl fumarate C6H8O4 144.13 Peng H. (2112) J Biol Chem. 287(33) 28017-26 Gesser B. (2007) Journal of Investigative Dermatology 27(9) 2129-37 Sigma Download

Results as Barchart

View results as a bar chart
1000µM
100µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
IR 60 5
TSSK1 73 11
Lck 74 2
MARK4 76 21
PAK4 76 5
CDK2-Cyclin A 77 8
SmMLCK 79 24
IKK epsilon 80 4
PKB beta 81 4
HIPK3 81 9
ROCK 2 81 18
SIK2 82 14
PHK 82 23
PRK2 83 31
IKK beta 84 3
TESK1 84 2
FGF-R1 85 7
ERK2 85 10
PAK5 87 9
p38 gamma MAPK 87 9
MAPKAP-K3 87 1
HIPK1 87 22
MLK1 87 18
AMPK (hum) 87 5
CSK 87 5
TrkA 88 13
IRAK4 88 13
MST2 88 23
CK1 delta 88 1
TTBK1 88 3
CAMK1 88 9
ERK5 88 0
BTK 88 37
PKC zeta 89 1
TBK1 89 14
ERK8 89 1
p38 alpha MAPK 90 11
CHK2 90 2
PAK6 90 0
RSK2 90 27
Aurora B 90 11
MEKK1 90 24
JNK2 90 9
BRSK2 91 11
CDK9-Cyclin T1 91 1
RSK1 91 11
SRPK1 91 5
MAP4K5 91 8
MARK2 91 4
DYRK2 91 17
TAO1 91 2
GSK3 beta 92 13
PKD1 92 25
TIE2 92 7
p38 delta MAPK 92 13
GCK 92 21
MAP4K3 92 1
CK1 gamma 2 92 1
MAPKAP-K2 92 3
MKK6 92 3
CAMKK beta 92 21
PKA 92 14
CLK2 92 9
MELK 93 0
RIPK2 93 17
STK33 93 5
PKB alpha 93 17
LKB1 93 19
TGFBR1 93 4
SGK1 93 8
IGF-1R 93 26
ASK1 93 8
PLK1 94 15
PDK1 94 21
MST4 95 17
MINK1 95 29
EIF2AK3 95 6
ERK1 95 10
OSR1 96 2
PIM3 96 17
MKK1 96 20
PRAK 96 0
TTBK2 96 0
NUAK1 97 15
ULK1 97 9
EPH-B3 97 13
TTK 98 14
SIK3 98 6
EPH-A4 98 4
CK2 98 13
HIPK2 98 0
MARK1 98 3
ABL 98 3
PKC alpha 99 7
PIM1 99 2
EF2K 99 21
S6K1 99 13
JNK1 99 14
DAPK1 99 11
BRSK1 100 30
JAK2 100 11
MLK3 100 14
NEK2a 100 6
CHK1 101 20
IRAK1 101 3
PDGFRA 101 8
MNK1 101 6
MNK2 101 1
EPH-B1 101 7
PAK2 101 1
BRK 102 1
JNK3 103 4
NEK6 103 19
DDR2 103 1
TLK1 103 8
IRR 103 9
MKK2 105 5
DYRK1A 105 7
MARK3 105 24
DYRK3 105 5
TAK1 105 11
PKC gamma 106 1
SYK 106 16
MST3 106 23
EPH-A2 106 17
ULK2 106 2
AMPK 106 8
MSK1 107 13
VEGFR1 108 2
WNK1 109 11
HER4 110 18
p38 beta MAPK 111 4
MPSK1 114 9
YES1 114 13
EPH-B4 115 24
ZAP70 116 8
PIM2 117 12
Aurora A 117 3
EPH-B2 118 10
Src 120 22
Screening Concentration: 100µM
Kinase % Activity Remainingsort descending Standard Deviation
IR 62 14
Lck 72 3
CDK2-Cyclin A 75 2
MAP4K3 81 7
CSK 82 8
TSSK1 85 7
MAPKAP-K2 86 1
PHK 87 30
MAP4K5 87 7
ERK2 88 27
ASK1 88 7
PAK4 88 19
MKK6 88 10
TESK1 89 4
ROCK 2 89 17
IKK beta 91 5
IGF-1R 92 5
JNK1 92 5
MARK4 92 7
RSK1 92 1
PRAK 92 5
CHK1 93 9
BRSK1 93 18
TTK 93 11
PKB beta 93 6
HIPK3 94 6
ERK5 94 0
DYRK2 94 6
JNK2 94 8
SIK2 94 17
CK1 delta 94 3
PKB alpha 94 7
MST2 95 25
CK2 95 5
MEKK1 95 13
HIPK1 95 17
AMPK (hum) 95 17
CAMK1 96 1
PKA 96 19
TrkA 96 2
GSK3 beta 96 21
IKK epsilon 96 11
p38 gamma MAPK 96 10
SGK1 96 0
MAPKAP-K3 97 4
LKB1 97 15
MLK3 97 2
CHK2 98 6
PAK6 98 4
CDK9-Cyclin T1 98 13
SmMLCK 99 5
p38 alpha MAPK 99 13
BRSK2 99 16
STK33 99 4
ULK1 99 18
ERK1 99 1
TTBK2 99 13
CLK2 100 8
NEK2a 100 3
IRAK1 100 1
DDR2 100 2
TBK1 100 8
TIE2 100 9
ERK8 100 5
PLK1 100 3
S6K1 101 10
PKC alpha 101 2
CK1 gamma 2 101 9
SRPK1 101 15
MKK2 101 13
TGFBR1 101 24
TTBK1 101 3
CAMKK beta 101 13
HIPK2 101 6
FGF-R1 101 21
DAPK1 102 5
p38 delta MAPK 102 18
Aurora B 102 8
JNK3 103 0
PKC zeta 103 17
MELK 103 14
PDGFRA 103 0
MNK1 103 12
RSK2 103 21
EPH-B1 103 6
PAK2 104 9
IRAK4 104 8
RIPK2 104 12
NUAK1 104 3
MST3 104 12
WNK1 104 19
AMPK 104 13
Src 104 5
ABL 105 9
JAK2 105 5
MSK1 105 7
EPH-A4 105 9
EPH-B3 105 5
MST4 106 12
PIM3 106 1
EF2K 106 6
OSR1 107 1
PIM1 107 5
GCK 107 14
MNK2 107 7
PDK1 107 10
EIF2AK3 107 8
MARK2 108 7
MARK3 108 16
PRK2 108 9
IRR 108 10
PKD1 108 11
DYRK1A 109 5
TAO1 109 18
SIK3 109 27
PIM2 109 9
MKK1 109 3
ULK2 109 5
NEK6 110 22
VEGFR1 110 3
p38 beta MAPK 112 20
BRK 112 11
MLK1 112 10
BTK 113 23
PKC gamma 113 14
MINK1 113 24
MARK1 115 1
TAK1 115 1
YES1 116 19
ZAP70 116 17
MPSK1 116 6
DYRK3 117 23
TLK1 117 1
SYK 118 17
EPH-B2 118 6
Aurora A 120 7
EPH-B4 122 10
HER4 123 34
EPH-A2 124 5
PAK5 125 6
Screening Concentration: 1000µM
Kinase % Activity Remainingsort descending Standard Deviation
IR 79 6
TSSK1 80 17
TrkA 83 11
Lck 84 2
PHK 84 20
PRK2 84 6
IKK beta 85 8
MAP4K3 85 18
HIPK3 86 11
CSK 86 3
PAK2 86 7
CDK2-Cyclin A 87 15
RSK1 90 9
CK2 91 2
BRSK1 91 3
PLK1 91 6
MAP4K5 91 20
PIM3 92 8
MAPKAP-K2 93 9
CAMKK beta 93 9
PAK5 93 11
IKK epsilon 93 0
TTK 93 11
PRAK 94 14
HIPK2 94 2
TGFBR1 95 11
ABL 95 6
PAK4 95 2
TTBK2 96 7
MARK4 96 12
ERK8 96 8
ERK5 97 8
CHK1 97 18
IRAK1 97 4
MST2 97 24
ROCK 2 98 19
VEGFR1 98 2
Aurora B 98 11
CAMK1 99 3
PKA 99 15
DDR2 99 23
TIE2 99 13
LKB1 100 1
ERK1 100 14
SGK1 100 11
JNK3 100 17
CHK2 100 2
CLK2 101 8
JNK2 101 13
NUAK1 101 16
PIM1 101 2
MST4 101 23
CK1 gamma 2 101 3
EIF2AK3 102 20
AMPK (hum) 102 15
SmMLCK 102 1
NEK2a 102 5
STK33 102 2
PKB alpha 103 5
MKK6 103 26
Src 103 14
DYRK2 103 2
TAK1 103 0
PAK6 103 11
CDK9-Cyclin T1 103 8
SIK2 103 9
SRPK1 103 11
ULK1 103 17
DAPK1 104 5
p38 beta MAPK 104 6
p38 gamma MAPK 104 5
PDGFRA 104 15
EPH-B1 104 15
CK1 delta 105 7
MLK3 105 20
ERK2 105 11
ASK1 105 0
PKC alpha 105 18
MNK1 105 11
MKK2 106 21
MAPKAP-K3 106 24
PKB beta 106 6
DYRK3 106 8
p38 alpha MAPK 106 14
TBK1 106 28
MELK 107 26
MARK1 108 16
HER4 108 6
BRSK2 108 15
GSK3 beta 108 18
ULK2 109 9
AMPK 109 2
TTBK1 109 27
FGF-R1 109 30
TESK1 109 4
JNK1 109 12
MPSK1 109 11
TLK1 110 1
p38 delta MAPK 110 20
BRK 110 2
SIK3 110 9
MNK2 110 14
PDK1 111 0
EF2K 111 10
MARK2 111 25
RIPK2 111 9
MEKK1 112 27
IRR 112 7
ZAP70 112 2
PKD1 112 14
MST3 112 6
DYRK1A 113 2
MSK1 113 22
EPH-B3 114 12
PKC gamma 114 6
GCK 114 33
Aurora A 114 14
WNK1 114 6
S6K1 115 9
JAK2 116 1
SYK 116 5
OSR1 116 8
PIM2 116 7
HIPK1 117 31
IGF-1R 117 5
IRAK4 117 7
RSK2 117 4
MKK1 118 15
YES1 118 10
PKC zeta 118 24
EPH-A4 119 0
EPH-B2 120 7
TAO1 123 17
NEK6 124 39
MINK1 129 36
EPH-A2 129 12
MARK3 132 9
MLK1 135 13
BTK 135 7
EPH-B4 136 26

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