Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Dimethyl fumarate C6H8O4 144.13 Peng H. (2112) J Biol Chem. 287(33) 28017-26 Gesser B. (2007) Journal of Investigative Dermatology 27(9) 2129-37 Sigma Download

Results as Barchart

View results as a bar chart
1000µM
100µM
10µM

Results as Table

Screening Concentration: 1000µM
Kinase % Activity Remaining Standard Deviation
MKK1 118 15
MKK2 106 21
MKK6 103 26
ERK1 100 14
ERK2 105 11
ERK5 97 8
JNK1 109 12
JNK2 101 13
JNK3 100 17
p38 alpha MAPK 106 14
p38 beta MAPK 104 6
p38 gamma MAPK 104 5
p38 delta MAPK 110 20
ERK8 96 8
RSK1 90 9
RSK2 117 4
PDK1 111 0
PKB alpha 103 5
PKB beta 106 6
SGK1 100 11
S6K1 115 9
PKA 99 15
ROCK 2 98 19
PRK2 84 6
PKC alpha 105 18
PKC gamma 114 6
PKC zeta 118 24
PKD1 112 14
STK33 102 2
MSK1 113 22
MNK1 105 11
MNK2 110 14
MAPKAP-K2 93 9
MAPKAP-K3 106 24
PRAK 94 14
CAMKK beta 93 9
CAMK1 99 3
SmMLCK 102 1
PHK 84 20
DAPK1 104 5
CHK1 97 18
CHK2 100 2
GSK3 beta 108 18
CDK2-Cyclin A 87 15
CDK9-Cyclin T1 103 8
PLK1 91 6
Aurora A 114 14
Aurora B 98 11
TLK1 110 1
LKB1 100 1
AMPK 109 2
AMPK (hum) 102 15
MARK1 108 16
MARK2 111 25
MARK3 132 9
MARK4 96 12
BRSK1 91 3
BRSK2 108 15
MELK 107 26
NUAK1 101 16
SIK2 103 9
SIK3 110 9
TSSK1 80 17
CK1 gamma 2 101 3
CK1 delta 105 7
CK2 91 2
TTBK1 109 27
TTBK2 96 7
DYRK1A 113 2
DYRK2 103 2
DYRK3 106 8
NEK2a 102 5
NEK6 124 39
IKK beta 85 8
IKK epsilon 93 0
TBK1 106 28
PIM1 101 2
PIM2 116 7
PIM3 92 8
SRPK1 103 11
EF2K 111 10
EIF2AK3 102 20
HIPK1 117 31
HIPK2 94 2
HIPK3 86 11
CLK2 101 8
PAK2 86 7
PAK4 95 2
PAK5 93 11
PAK6 103 11
MST2 97 24
MST3 112 6
MST4 101 23
GCK 114 33
MAP4K3 85 18
MAP4K5 91 20
MINK1 129 36
MEKK1 112 27
MLK1 135 13
MLK3 105 20
TESK1 109 4
TAO1 123 17
ASK1 105 0
TAK1 103 0
IRAK1 97 4
IRAK4 117 7
RIPK2 111 9
OSR1 116 8
TTK 93 11
MPSK1 109 11
WNK1 114 6
ULK1 103 17
ULK2 109 9
TGFBR1 95 11
Src 103 14
Lck 84 2
CSK 86 3
YES1 118 10
ABL 95 6
BTK 135 7
JAK2 116 1
SYK 116 5
ZAP70 112 2
TIE2 99 13
BRK 110 2
EPH-A2 129 12
EPH-A4 119 0
EPH-B1 104 15
EPH-B2 120 7
EPH-B3 114 12
EPH-B4 136 26
FGF-R1 109 30
HER4 108 6
IGF-1R 117 5
IR 79 6
IRR 112 7
TrkA 83 11
DDR2 99 23
VEGFR1 98 2
PDGFRA 104 15
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 96 20
MKK2 105 5
MKK6 92 3
ERK1 95 10
ERK2 85 10
ERK5 88 0
JNK1 99 14
JNK2 90 9
JNK3 103 4
p38 alpha MAPK 90 11
p38 beta MAPK 111 4
p38 gamma MAPK 87 9
p38 delta MAPK 92 13
ERK8 89 1
RSK1 91 11
RSK2 90 27
PDK1 94 21
PKB alpha 93 17
PKB beta 81 4
SGK1 93 8
S6K1 99 13
PKA 92 14
ROCK 2 81 18
PRK2 83 31
PKC alpha 99 7
PKC gamma 106 1
PKC zeta 89 1
PKD1 92 25
STK33 93 5
MSK1 107 13
MNK1 101 6
MNK2 101 1
MAPKAP-K2 92 3
MAPKAP-K3 87 1
PRAK 96 0
CAMKK beta 92 21
CAMK1 88 9
SmMLCK 79 24
PHK 82 23
DAPK1 99 11
CHK1 101 20
CHK2 90 2
GSK3 beta 92 13
CDK2-Cyclin A 77 8
CDK9-Cyclin T1 91 1
PLK1 94 15
Aurora A 117 3
Aurora B 90 11
TLK1 103 8
LKB1 93 19
AMPK 106 8
AMPK (hum) 87 5
MARK1 98 3
MARK2 91 4
MARK3 105 24
MARK4 76 21
BRSK1 100 30
BRSK2 91 11
MELK 93 0
NUAK1 97 15
SIK2 82 14
SIK3 98 6
TSSK1 73 11
CK1 gamma 2 92 1
CK1 delta 88 1
CK2 98 13
TTBK1 88 3
TTBK2 96 0
DYRK1A 105 7
DYRK2 91 17
DYRK3 105 5
NEK2a 100 6
NEK6 103 19
IKK beta 84 3
IKK epsilon 80 4
TBK1 89 14
PIM1 99 2
PIM2 117 12
PIM3 96 17
SRPK1 91 5
EF2K 99 21
EIF2AK3 95 6
HIPK1 87 22
HIPK2 98 0
HIPK3 81 9
CLK2 92 9
PAK2 101 1
PAK4 76 5
PAK5 87 9
PAK6 90 0
MST2 88 23
MST3 106 23
MST4 95 17
GCK 92 21
MAP4K3 92 1
MAP4K5 91 8
MINK1 95 29
MEKK1 90 24
MLK1 87 18
MLK3 100 14
TESK1 84 2
TAO1 91 2
ASK1 93 8
TAK1 105 11
IRAK1 101 3
IRAK4 88 13
RIPK2 93 17
OSR1 96 2
TTK 98 14
MPSK1 114 9
WNK1 109 11
ULK1 97 9
ULK2 106 2
TGFBR1 93 4
Src 120 22
Lck 74 2
CSK 87 5
YES1 114 13
ABL 98 3
BTK 88 37
JAK2 100 11
SYK 106 16
ZAP70 116 8
TIE2 92 7
BRK 102 1
EPH-A2 106 17
EPH-A4 98 4
EPH-B1 101 7
EPH-B2 118 10
EPH-B3 97 13
EPH-B4 115 24
FGF-R1 85 7
HER4 110 18
IGF-1R 93 26
IR 60 5
IRR 103 9
TrkA 88 13
DDR2 103 1
VEGFR1 108 2
PDGFRA 101 8
Screening Concentration: 100µM
Kinase % Activity Remaining Standard Deviation
MKK1 109 3
MKK2 101 13
MKK6 88 10
ERK1 99 1
ERK2 88 27
ERK5 94 0
JNK1 92 5
JNK2 94 8
JNK3 103 0
p38 alpha MAPK 99 13
p38 beta MAPK 112 20
p38 gamma MAPK 96 10
p38 delta MAPK 102 18
ERK8 100 5
RSK1 92 1
RSK2 103 21
PDK1 107 10
PKB alpha 94 7
PKB beta 93 6
SGK1 96 0
S6K1 101 10
PKA 96 19
ROCK 2 89 17
PRK2 108 9
PKC alpha 101 2
PKC gamma 113 14
PKC zeta 103 17
PKD1 108 11
STK33 99 4
MSK1 105 7
MNK1 103 12
MNK2 107 7
MAPKAP-K2 86 1
MAPKAP-K3 97 4
PRAK 92 5
CAMKK beta 101 13
CAMK1 96 1
SmMLCK 99 5
PHK 87 30
DAPK1 102 5
CHK1 93 9
CHK2 98 6
GSK3 beta 96 21
CDK2-Cyclin A 75 2
CDK9-Cyclin T1 98 13
PLK1 100 3
Aurora A 120 7
Aurora B 102 8
TLK1 117 1
LKB1 97 15
AMPK 104 13
AMPK (hum) 95 17
MARK1 115 1
MARK2 108 7
MARK3 108 16
MARK4 92 7
BRSK1 93 18
BRSK2 99 16
MELK 103 14
NUAK1 104 3
SIK2 94 17
SIK3 109 27
TSSK1 85 7
CK1 gamma 2 101 9
CK1 delta 94 3
CK2 95 5
TTBK1 101 3
TTBK2 99 13
DYRK1A 109 5
DYRK2 94 6
DYRK3 117 23
NEK2a 100 3
NEK6 110 22
IKK beta 91 5
IKK epsilon 96 11
TBK1 100 8
PIM1 107 5
PIM2 109 9
PIM3 106 1
SRPK1 101 15
EF2K 106 6
EIF2AK3 107 8
HIPK1 95 17
HIPK2 101 6
HIPK3 94 6
CLK2 100 8
PAK2 104 9
PAK4 88 19
PAK5 125 6
PAK6 98 4
MST2 95 25
MST3 104 12
MST4 106 12
GCK 107 14
MAP4K3 81 7
MAP4K5 87 7
MINK1 113 24
MEKK1 95 13
MLK1 112 10
MLK3 97 2
TESK1 89 4
TAO1 109 18
ASK1 88 7
TAK1 115 1
IRAK1 100 1
IRAK4 104 8
RIPK2 104 12
OSR1 107 1
TTK 93 11
MPSK1 116 6
WNK1 104 19
ULK1 99 18
ULK2 109 5
TGFBR1 101 24
Src 104 5
Lck 72 3
CSK 82 8
YES1 116 19
ABL 105 9
BTK 113 23
JAK2 105 5
SYK 118 17
ZAP70 116 17
TIE2 100 9
BRK 112 11
EPH-A2 124 5
EPH-A4 105 9
EPH-B1 103 6
EPH-B2 118 6
EPH-B3 105 5
EPH-B4 122 10
FGF-R1 101 21
HER4 123 34
IGF-1R 92 5
IR 62 14
IRR 108 10
TrkA 96 2
DDR2 100 2
VEGFR1 110 3
PDGFRA 103 0

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