Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BAY 61-3606 C20H18N6O3 · xHCl · yH2O 390.40 Syk Yamamoto N. (2003) J. Pharmacol. Exp. Ther. 306 1174-1181 Sigma Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
NUAK1 1 0
GCK 5 1
IGF-1R 6 1
CLK2 12 2
IR 13 1
ROCK 2 14 1
TAK1 14 0
GSK3 beta 16 2
PRK2 21 3
CDK9-Cyclin T1 21 9
MLK3 22 4
CDK2-Cyclin A 23 1
HIPK2 24 8
DYRK3 24 4
IRR 25 4
MAP4K3 29 4
RIPK2 29 1
PKD1 29 6
IRAK1 31 3
SYK 32 1
MLK1 33 3
DYRK2 36 2
PDGFRA 38 5
ERK8 39 7
CAMKK beta 43 3
MARK3 44 2
PIM3 45 2
BTK 46 1
PKC alpha 46 1
Aurora B 48 1
VEGFR1 50 9
YES1 51 15
MAP4K5 52 0
MKK6 55 2
IKK beta 55 2
MST2 55 3
MNK2 56 1
HIPK1 56 6
DYRK1A 58 1
JAK2 58 7
MINK1 59 4
LKB1 59 0
AMPK (hum) 59 35
IKK epsilon 60 9
JNK3 62 5
Src 63 6
ERK2 65 7
STK33 66 2
FGF-R1 67 15
ERK5 67 4
ULK1 68 5
IRAK4 68 8
MARK2 69 10
TAO1 69 5
PIM1 69 1
ERK1 71 12
PAK5 71 3
MELK 71 6
TTK 71 1
SIK2 72 2
MNK1 73 0
HIPK3 73 4
BRK 73 14
DAPK1 74 1
MARK4 74 12
CK1 delta 75 2
S6K1 75 7
JNK2 75 9
PAK4 75 12
EPH-A2 76 5
Lck 76 1
ASK1 77 0
EPH-A4 78 1
BRSK2 78 12
TBK1 78 8
MST4 78 16
SIK3 79 2
PKB beta 79 15
MST3 79 1
PHK 80 4
PAK6 80 9
MSK1 81 4
PIM2 81 10
RSK1 82 7
SRPK1 82 3
MAPKAP-K3 82 5
EIF2AK3 82 1
MEKK1 82 2
NEK2a 82 7
NEK6 82 10
ZAP70 82 5
MKK2 83 18
CHK2 83 5
TESK1 84 2
HER4 84 4
p38 beta MAPK 84 11
p38 gamma MAPK 84 13
PKC zeta 85 7
p38 delta MAPK 85 3
PLK1 86 12
EPH-B1 86 2
EPH-B2 86 3
BRSK1 86 2
TTBK1 87 10
TSSK1 88 14
CSK 88 9
SGK1 89 6
MARK1 89 5
OSR1 89 11
EF2K 90 3
ULK2 91 14
ABL 91 9
MKK1 92 10
TrkA 92 47
DDR2 92 9
CK1 gamma 2 93 11
TLK1 93 4
CK2 93 9
EPH-B4 93 2
PDK1 94 17
TGFBR1 94 2
SmMLCK 94 16
JNK1 94 3
WNK1 96 7
TTBK2 98 2
EPH-B3 99 8
PKA 99 12
CAMK1 100 11
AMPK 101 2
PAK2 102 6
MPSK1 103 13
PRAK 103 18
PKC gamma 103 12
PKB alpha 106 12
p38 alpha MAPK 107 10
CHK1 108 12
RSK2 113 12
TIE2 113 2
Aurora A 114 17
MAPKAP-K2 146 51
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
GCK 4 1
IGF-1R 10 4
CLK2 14 1
GSK3 beta 15 5
IR 16 1
TAK1 16 1
ROCK 2 18 0
MLK3 20 1
DYRK3 24 2
CDK2-Cyclin A 25 3
HIPK2 25 1
NUAK1 26 1
CDK9-Cyclin T1 26 7
PKD1 27 1
IRR 29 2
IRAK1 31 0
RIPK2 32 0
PRK2 32 3
MAP4K3 34 4
SYK 36 2
MLK1 36 2
CAMKK beta 37 8
PDGFRA 40 1
Aurora B 40 3
DYRK2 40 0
MARK3 49 7
MST2 50 8
LKB1 50 5
IKK epsilon 51 1
DYRK1A 51 0
Src 54 12
ERK8 55 23
IKK beta 56 4
MAP4K5 56 5
MARK2 56 5
PKC alpha 56 1
PIM1 59 9
BTK 59 1
MKK6 62 3
HIPK1 62 12
MELK 63 13
YES1 63 15
MARK4 64 3
TSSK1 65 17
ERK5 67 1
CHK2 68 3
ERK2 68 7
MNK2 69 11
ERK1 69 7
FGF-R1 69 11
JAK2 69 7
PIM3 70 41
p38 beta MAPK 71 2
VEGFR1 71 15
EF2K 71 1
HIPK3 71 2
CK1 delta 72 4
JNK2 72 11
ULK1 73 1
JNK3 73 11
TTK 74 10
MSK1 74 5
Lck 74 8
PAK4 74 7
PAK5 74 2
MST3 75 10
STK33 75 5
SIK2 75 2
S6K1 75 4
TESK1 75 7
TAO1 75 2
PKC zeta 76 5
p38 gamma MAPK 76 8
BRSK2 77 10
DAPK1 77 9
IRAK4 78 9
EPH-B1 78 2
MINK1 78 7
ZAP70 79 7
PLK1 79 9
NEK2a 79 7
TLK1 80 12
MKK2 80 6
TrkA 80 30
SRPK1 81 1
PAK6 82 3
MKK1 82 6
ASK1 82 7
MST4 83 5
PIM2 83 9
MNK1 83 4
PKA 84 2
PHK 84 12
TBK1 85 13
CSK 85 8
JNK1 85 3
p38 delta MAPK 87 0
EPH-B2 87 1
AMPK 87 3
EPH-A4 88 10
MEKK1 88 10
BRK 89 1
EPH-B3 89 1
EPH-B4 89 8
AMPK (hum) 89 12
MARK1 89 2
PAK2 89 1
BRSK1 89 11
SIK3 90 4
CHK1 91 18
CK1 gamma 2 92 4
PKB alpha 92 6
DDR2 93 1
OSR1 93 13
TTBK1 93 19
PDK1 94 3
WNK1 95 9
MAPKAP-K3 95 21
EIF2AK3 95 2
EPH-A2 96 15
ULK2 96 4
CK2 96 9
MPSK1 98 24
TGFBR1 98 7
TTBK2 98 10
PKC gamma 99 4
MAPKAP-K2 99 4
NEK6 99 17
SGK1 100 1
ABL 100 6
PRAK 101 7
CAMK1 101 3
RSK1 102 21
p38 alpha MAPK 103 10
HER4 103 2
TIE2 105 0
PKB beta 106 19
Aurora A 110 12
SmMLCK 111 10
RSK2 117 3

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