Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BAY 61-3606 C20H18N6O3 · xHCl · yH2O 390.40 Syk Yamamoto N. (2003) J. Pharmacol. Exp. Ther. 306 1174-1181 Sigma Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 92 10
MKK2 83 18
MKK6 55 2
ERK1 71 12
ERK2 65 7
ERK5 67 4
JNK1 94 3
JNK2 75 9
JNK3 62 5
p38 alpha MAPK 107 10
p38 beta MAPK 84 11
p38 gamma MAPK 84 13
p38 delta MAPK 85 3
ERK8 39 7
RSK1 82 7
RSK2 113 12
PDK1 94 17
PKB alpha 106 12
PKB beta 79 15
SGK1 89 6
S6K1 75 7
PKA 99 12
ROCK 2 14 1
PRK2 21 3
PKC alpha 46 1
PKC gamma 103 12
PKC zeta 85 7
PKD1 29 6
STK33 66 2
MSK1 81 4
MNK1 73 0
MNK2 56 1
MAPKAP-K2 146 51
MAPKAP-K3 82 5
PRAK 103 18
CAMKK beta 43 3
CAMK1 100 11
SmMLCK 94 16
PHK 80 4
DAPK1 74 1
CHK1 108 12
CHK2 83 5
GSK3 beta 16 2
CDK2-Cyclin A 23 1
CDK9-Cyclin T1 21 9
PLK1 86 12
Aurora A 114 17
Aurora B 48 1
TLK1 93 4
LKB1 59 0
AMPK 101 2
AMPK (hum) 59 35
MARK1 89 5
MARK2 69 10
MARK3 44 2
MARK4 74 12
BRSK1 86 2
BRSK2 78 12
MELK 71 6
NUAK1 1 0
SIK2 72 2
SIK3 79 2
TSSK1 88 14
CK1 gamma 2 93 11
CK1 delta 75 2
CK2 93 9
TTBK1 87 10
TTBK2 98 2
DYRK1A 58 1
DYRK2 36 2
DYRK3 24 4
NEK2a 82 7
NEK6 82 10
IKK beta 55 2
IKK epsilon 60 9
TBK1 78 8
PIM1 69 1
PIM2 81 10
PIM3 45 2
SRPK1 82 3
EF2K 90 3
EIF2AK3 82 1
HIPK1 56 6
HIPK2 24 8
HIPK3 73 4
CLK2 12 2
PAK2 102 6
PAK4 75 12
PAK5 71 3
PAK6 80 9
MST2 55 3
MST3 79 1
MST4 78 16
GCK 5 1
MAP4K3 29 4
MAP4K5 52 0
MINK1 59 4
MEKK1 82 2
MLK1 33 3
MLK3 22 4
TESK1 84 2
TAO1 69 5
ASK1 77 0
TAK1 14 0
IRAK1 31 3
IRAK4 68 8
RIPK2 29 1
OSR1 89 11
TTK 71 1
MPSK1 103 13
WNK1 96 7
ULK1 68 5
ULK2 91 14
TGFBR1 94 2
Src 63 6
Lck 76 1
CSK 88 9
YES1 51 15
ABL 91 9
BTK 46 1
JAK2 58 7
SYK 32 1
ZAP70 82 5
TIE2 113 2
BRK 73 14
EPH-A2 76 5
EPH-A4 78 1
EPH-B1 86 2
EPH-B2 86 3
EPH-B3 99 8
EPH-B4 93 2
FGF-R1 67 15
HER4 84 4
IGF-1R 6 1
IR 13 1
IRR 25 4
TrkA 92 47
DDR2 92 9
VEGFR1 50 9
PDGFRA 38 5
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 82 6
MKK2 80 6
MKK6 62 3
ERK1 69 7
ERK2 68 7
ERK5 67 1
JNK1 85 3
JNK2 72 11
JNK3 73 11
p38 alpha MAPK 103 10
p38 beta MAPK 71 2
p38 gamma MAPK 76 8
p38 delta MAPK 87 0
ERK8 55 23
RSK1 102 21
RSK2 117 3
PDK1 94 3
PKB alpha 92 6
PKB beta 106 19
SGK1 100 1
S6K1 75 4
PKA 84 2
ROCK 2 18 0
PRK2 32 3
PKC alpha 56 1
PKC gamma 99 4
PKC zeta 76 5
PKD1 27 1
STK33 75 5
MSK1 74 5
MNK1 83 4
MNK2 69 11
MAPKAP-K2 99 4
MAPKAP-K3 95 21
PRAK 101 7
CAMKK beta 37 8
CAMK1 101 3
SmMLCK 111 10
PHK 84 12
DAPK1 77 9
CHK1 91 18
CHK2 68 3
GSK3 beta 15 5
CDK2-Cyclin A 25 3
CDK9-Cyclin T1 26 7
PLK1 79 9
Aurora A 110 12
Aurora B 40 3
TLK1 80 12
LKB1 50 5
AMPK 87 3
AMPK (hum) 89 12
MARK1 89 2
MARK2 56 5
MARK3 49 7
MARK4 64 3
BRSK1 89 11
BRSK2 77 10
MELK 63 13
NUAK1 26 1
SIK2 75 2
SIK3 90 4
TSSK1 65 17
CK1 gamma 2 92 4
CK1 delta 72 4
CK2 96 9
TTBK1 93 19
TTBK2 98 10
DYRK1A 51 0
DYRK2 40 0
DYRK3 24 2
NEK2a 79 7
NEK6 99 17
IKK beta 56 4
IKK epsilon 51 1
TBK1 85 13
PIM1 59 9
PIM2 83 9
PIM3 70 41
SRPK1 81 1
EF2K 71 1
EIF2AK3 95 2
HIPK1 62 12
HIPK2 25 1
HIPK3 71 2
CLK2 14 1
PAK2 89 1
PAK4 74 7
PAK5 74 2
PAK6 82 3
MST2 50 8
MST3 75 10
MST4 83 5
GCK 4 1
MAP4K3 34 4
MAP4K5 56 5
MINK1 78 7
MEKK1 88 10
MLK1 36 2
MLK3 20 1
TESK1 75 7
TAO1 75 2
ASK1 82 7
TAK1 16 1
IRAK1 31 0
IRAK4 78 9
RIPK2 32 0
OSR1 93 13
TTK 74 10
MPSK1 98 24
WNK1 95 9
ULK1 73 1
ULK2 96 4
TGFBR1 98 7
Src 54 12
Lck 74 8
CSK 85 8
YES1 63 15
ABL 100 6
BTK 59 1
JAK2 69 7
SYK 36 2
ZAP70 79 7
TIE2 105 0
BRK 89 1
EPH-A2 96 15
EPH-A4 88 10
EPH-B1 78 2
EPH-B2 87 1
EPH-B3 89 1
EPH-B4 89 8
FGF-R1 69 11
HER4 103 2
IGF-1R 10 4
IR 16 1
IRR 29 2
TrkA 80 30
DDR2 93 1
VEGFR1 71 15
PDGFRA 40 1

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