Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Saracatinib (AZD0530) C27H32ClN5O5 542.03 Src H Laurent (2006) J. Med. Chem. 49(22) 6465-6488 Selleck Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 111 11
MKK2 114 1
MKK6 118 12
ERK1 99 8
ERK2 114 11
ERK5 96 1
JNK1 103 2
JNK2 87 4
JNK3 113 1
p38 alpha MAPK 106 1
p38 beta MAPK 87 9
p38 gamma MAPK 107 3
p38 delta MAPK 99 7
ERK8 122 6
RSK1 89 8
RSK2 114 7
PDK1 101 15
PKB alpha 112 12
PKB beta 101 11
SGK1 101 2
S6K1 108 10
PKA 100 6
ROCK 2 145 13
PRK2 96 1
PKC alpha 65 28
PKC gamma 113 10
PKC zeta 107 4
PKD1 110 2
STK33 87 3
MSK1 115 12
MNK1 119 2
MNK2 109 0
MAPKAP-K2 106 9
MAPKAP-K3 94 14
PRAK 110 6
CAMKK beta 107 4
CAMK1 97 0
SmMLCK 92 1
PHK 109 9
DAPK1 100 22
CHK1 100 15
CHK2 100 11
GSK3 beta 103 5
CDK2-Cyclin A 100 5
CDK9-Cyclin T1 91 2
PLK1 122 2
Aurora A 100 9
Aurora B 91 5
TLK1 109 6
LKB1 116 36
AMPK 118 17
AMPK (hum) 125 12
MARK1 114 20
MARK2 115 9
MARK3 125 5
MARK4 114 13
BRSK1 121 9
BRSK2 107 14
MELK 128 5
NUAK1 118 9
SIK2 39 9
SIK3 82 22
TSSK1 100 2
CK1 gamma 2 102 3
CK1 delta 119 7
CK2 93 15
TTBK1 104 2
TTBK2 104 2
DYRK1A 105 9
DYRK2 108 4
DYRK3 100 1
NEK2a 102 1
NEK6 128 2
IKK beta 109 7
IKK epsilon 131 8
TBK1 71 20
PIM1 101 26
PIM2 90 3
PIM3 108 7
SRPK1 110 32
EF2K 101 1
EIF2AK3 105 3
HIPK1 109 19
HIPK2 95 12
HIPK3 101 1
CLK2 107 1
PAK2 90 15
PAK4 111 11
PAK5 104 4
PAK6 104 4
MST2 93 0
MST3 123 21
MST4 89 15
GCK 94 16
MAP4K3 108 9
MAP4K5 77 1
MINK1 84 6
MEKK1 109 10
MLK1 108 30
MLK3 121 0
TESK1 97 0
TAO1 107 3
ASK1 100 1
TAK1 124 5
IRAK1 109 13
IRAK4 97 7
RIPK2 19 6
OSR1 102 8
TTK 78 37
MPSK1 114 8
WNK1 118 5
ULK1 96 2
ULK2 101 1
TGFBR1 143 3
Src 3 1
Lck 108 2
CSK 79 4
YES1 30 13
ABL 27 1
BTK 73 14
JAK2 104 7
SYK 87 3
ZAP70 106 11
TIE2 89 22
BRK 30 13
EPH-A2 48 2
EPH-A4 34 3
EPH-B1 60 9
EPH-B2 63 2
EPH-B3 121 14
EPH-B4 58 11
FGF-R1 91 14
HER4 45 7
IGF-1R 98 20
IR 113 15
IRR 105 1
TrkA 71 1
DDR2 20 4
VEGFR1 106 1
PDGFRA 100 2
PINK 102 6
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 103 1
MKK2 99 17
MKK6 145 7
ERK1 94 13
ERK2 118 5
ERK5 87 3
JNK1 101 5
JNK2 100 8
JNK3 105 5
p38 alpha MAPK 71 1
p38 beta MAPK 92 6
p38 gamma MAPK 91 7
p38 delta MAPK 91 7
ERK8 110 7
RSK1 101 12
RSK2 123 2
PDK1 103 9
PKB alpha 103 4
PKB beta 112 4
SGK1 96 2
S6K1 93 4
PKA 101 9
ROCK 2 142 12
PRK2 98 0
PKC alpha 97 1
PKC gamma 101 20
PKC zeta 98 3
PKD1 109 3
STK33 92 6
MSK1 99 3
MNK1 113 1
MNK2 104 13
MAPKAP-K2 109 5
MAPKAP-K3 108 7
PRAK 109 0
CAMKK beta 102 5
CAMK1 108 3
SmMLCK 97 1
PHK 109 4
DAPK1 117 16
CHK1 110 12
CHK2 114 6
GSK3 beta 93 11
CDK2-Cyclin A 115 6
CDK9-Cyclin T1 96 2
PLK1 104 8
Aurora A 115 4
Aurora B 97 2
TLK1 101 9
LKB1 95 8
AMPK 130 20
AMPK (hum) 113 12
MARK1 94 7
MARK2 113 10
MARK3 124 7
MARK4 102 7
BRSK1 109 0
BRSK2 114 18
MELK 111 9
NUAK1 115 4
SIK2 10 1
SIK3 50 5
TSSK1 96 15
CK1 gamma 2 114 11
CK1 delta 105 10
CK2 88 7
TTBK1 109 7
TTBK2 97 0
DYRK1A 106 9
DYRK2 106 2
DYRK3 106 3
NEK2a 113 5
NEK6 115 22
IKK beta 95 6
IKK epsilon 116 5
TBK1 92 8
PIM1 104 20
PIM2 88 4
PIM3 106 11
SRPK1 120 1
EF2K 113 8
EIF2AK3 97 4
HIPK1 172 95
HIPK2 101 2
HIPK3 105 3
CLK2 112 1
PAK2 100 1
PAK4 114 1
PAK5 96 3
PAK6 106 6
MST2 93 6
MST3 105 6
MST4 103 4
GCK 85 5
MAP4K3 105 1
MAP4K5 25 3
MINK1 36 2
MEKK1 101 8
MLK1 101 9
MLK3 92 11
TESK1 83 6
TAO1 108 4
ASK1 96 5
TAK1 112 3
IRAK1 54 7
IRAK4 64 3
RIPK2 14 7
OSR1 95 8
TTK 92 1
MPSK1 108 3
WNK1 105 1
ULK1 99 2
ULK2 91 10
TGFBR1 64 3
Src 1 1
Lck 115 14
CSK 28 10
YES1 9 7
ABL 3 1
BTK 21 3
JAK2 84 2
SYK 77 11
ZAP70 111 8
TIE2 102 7
BRK 3 3
EPH-A2 14 4
EPH-A4 7 1
EPH-B1 13 0
EPH-B2 49 7
EPH-B3 80 13
EPH-B4 8 1
FGF-R1 92 8
HER4 82 6
IGF-1R 97 3
IR 111 6
IRR 83 4
TrkA 28 5
DDR2 2 0
VEGFR1 94 2
PDGFRA 77 6
PINK 113 1

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