Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
NG-25 C29H30F3N5O2 537.58 TAK1 Dzamko N (2012) PLoS ONE 7(6) e39132 10 1371 Eduardo Pauls (2012) Journal of Biological Chemistry 287 23 19216-19228 MedChem Express Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 108 8
MKK2 116 13
MKK6 158 0
ERK1 103 5
ERK2 102 4
JNK1 62 2
JNK2 22 2
JNK3 92 3
p38 alpha MAPK 3 2
p38 beta MAPK 17 4
p38 gamma MAPK 38 1
p38 delta MAPK 34 0
ERK8 89 15
RSK1 84 15
RSK2 94 1
PDK1 100 2
PKB alpha 100 19
PKB beta 114 0
SGK1 73 12
S6K1 64 7
PKA 93 3
ROCK 2 71 4
PRK2 93 7
PKC alpha 84 1
PKC gamma 102 4
PKC zeta 96 1
PKD1 86 1
STK33 97 7
MSK1 46 1
MNK1 104 1
MNK2 112 13
MAPKAP-K2 122 1
MAPKAP-K3 82 6
PRAK 97 5
CAMKK beta 71 3
CAMK1 17 3
SmMLCK 89 2
PHK 112 1
DAPK1 81 10
CHK1 105 5
CHK2 103 21
GSK3 beta 104 8
CDK2-Cyclin A 112 6
PLK1 92 3
Aurora A 121 14
Aurora B 108 7
TLK1 92 11
LKB1 107 6
AMPK 92 5
MARK1 97 3
MARK2 74 6
MARK3 99 17
MARK4 104 4
BRSK1 96 4
BRSK2 95 16
MELK 99 5
NUAK1 91 4
CK1 delta 115 7
CK2 94 1
DYRK1A 98 5
DYRK2 101 13
DYRK3 86 13
NEK2a 107 3
NEK6 85 5
IKK beta 101 4
IKK epsilon 97 21
TBK1 100 21
PIM1 117 7
PIM2 95 16
PIM3 108 18
SRPK1 97 0
EF2K 102 3
EIF2AK3 65 2
HIPK1 71 4
HIPK2 60 7
HIPK3 70 7
CLK2 104 9
PAK2 100 3
PAK4 99 11
PAK5 104 10
PAK6 90 5
MST2 124 10
MST4 78 10
GCK 12 4
MINK1 11 4
MEKK1 111 4
MLK1 90 9
MLK3 50 2
TAO1 67 19
ASK1 105 1
TAK1 7 2
IRAK1 72 6
IRAK4 102 0
RIPK2 79 3
OSR1 11 0
TTK 98 1
MPSK1 91 4
Src 10 1
Lck 1 0
CSK 15 4
YES1 10 1
ABL 4 0
BTK 85 4
JAK2 92 8
SYK 47 4
ZAP70 90 1
TIE2 91 1
BRK 43 4
EPH-A2 20 4
EPH-A4 29 1
EPH-B1 106 4
EPH-B2 23 5
EPH-B3 29 4
EPH-B4 93 10
FGF-R1 24 9
HER4 77 19
IGF-1R 85 11
IR 82 4
IRR 91 2
TrkA 78 2
VEGFR1 15 5
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 93 8
MKK2 97 16
MKK6 133 2
ERK1 100 11
ERK2 106 0
JNK1 14 2
JNK2 5 2
JNK3 32 4
p38 alpha MAPK 3 2
p38 beta MAPK 9 0
p38 gamma MAPK 11 9
p38 delta MAPK 7 2
ERK8 45 7
RSK1 38 6
RSK2 76 1
PDK1 85 1
PKB alpha 69 8
PKB beta 49 8
SGK1 52 10
S6K1 13 3
PKA 76 0
ROCK 2 25 2
PRK2 79 6
PKC alpha 90 6
PKC gamma 106 7
PKC zeta 93 4
PKD1 39 1
STK33 80 5
MSK1 21 2
MNK1 83 11
MNK2 83 2
MAPKAP-K2 113 14
MAPKAP-K3 97 5
PRAK 92 13
CAMKK beta 21 2
CAMK1 4 2
SmMLCK 77 4
PHK 102 10
DAPK1 84 0
CHK1 110 2
CHK2 68 4
GSK3 beta 101 15
CDK2-Cyclin A 100 1
PLK1 95 0
Aurora A 102 1
Aurora B 118 16
TLK1 92 5
LKB1 129 36
AMPK 85 2
MARK1 103 9
MARK2 85 4
MARK3 105 10
MARK4 89 1
BRSK1 109 7
BRSK2 89 0
MELK 64 4
NUAK1 85 4
CK1 delta 94 13
CK2 99 2
DYRK1A 85 23
DYRK2 95 16
DYRK3 82 13
NEK2a 93 3
NEK6 73 7
IKK beta 45 2
IKK epsilon 80 26
TBK1 96 4
PIM1 87 10
PIM2 102 11
PIM3 99 4
SRPK1 73 8
EF2K 100 17
EIF2AK3 21 5
HIPK1 29 7
HIPK2 13 3
HIPK3 20 3
CLK2 76 7
PAK2 69 8
PAK4 78 5
PAK5 88 5
PAK6 94 19
MST2 91 14
MST4 32 1
GCK 9 5
MINK1 5 0
MEKK1 108 12
MLK1 40 4
MLK3 9 0
TAO1 27 7
ASK1 76 5
TAK1 4 1
IRAK1 33 10
IRAK4 89 17
RIPK2 14 4
OSR1 2 0
TTK 66 1
MPSK1 99 14
Src 3 1
Lck 6 8
CSK 8 4
YES1 11 0
ABL 1 0
BTK 34 9
JAK2 42 3
SYK 12 1
ZAP70 60 5
TIE2 60 3
BRK 7 2
EPH-A2 14 8
EPH-A4 8 0
EPH-B1 67 17
EPH-B2 3 0
EPH-B3 8 1
EPH-B4 43 5
FGF-R1 8 1
HER4 37 0
IGF-1R 6 1
IR 18 1
IRR 46 4
TrkA 43 2
VEGFR1 3 2
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 106 19
MKK2 131 0
MKK6 118 5
ERK1 99 18
ERK2 101 2
JNK1 94 13
JNK2 91 9
JNK3 116 12
p38 alpha MAPK 41 5
p38 beta MAPK 75 4
p38 gamma MAPK 89 1
p38 delta MAPK 99 1
ERK8 106 8
RSK1 107 1
RSK2 95 19
PDK1 98 2
PKB alpha 105 14
PKB beta 105 3
SGK1 101 16
S6K1 107 4
PKA 100 1
ROCK 2 92 7
PRK2 102 4
PKC alpha 94 2
PKC gamma 108 9
PKC zeta 99 3
PKD1 101 2
STK33 106 15
MSK1 81 9
MNK1 98 8
MNK2 109 6
MAPKAP-K2 110 12
MAPKAP-K3 90 13
PRAK 105 22
CAMKK beta 98 0
CAMK1 69 2
SmMLCK 109 5
PHK 102 4
DAPK1 89 6
CHK1 114 8
CHK2 117 16
GSK3 beta 102 1
CDK2-Cyclin A 110 4
PLK1 103 5
Aurora A 120 9
Aurora B 116 13
TLK1 107 10
LKB1 117 1
AMPK 106 2
MARK1 114 12
MARK2 93 4
MARK3 112 15
MARK4 116 2
BRSK1 101 10
BRSK2 100 1
MELK 115 17
NUAK1 86 3
CK1 delta 112 9
CK2 90 9
DYRK1A 107 5
DYRK2 102 20
DYRK3 97 9
NEK2a 112 8
NEK6 104 14
IKK beta 114 1
IKK epsilon 106 12
TBK1 113 20
PIM1 120 0
PIM2 106 5
PIM3 107 9
SRPK1 102 10
EF2K 110 14
EIF2AK3 99 3
HIPK1 95 1
HIPK2 105 8
HIPK3 110 11
CLK2 115 6
PAK2 116 8
PAK4 109 2
PAK5 108 9
PAK6 104 12
MST2 111 23
MST4 95 7
GCK 24 3
MINK1 76 15
MEKK1 127 7
MLK1 106 23
MLK3 95 6
TAO1 99 16
ASK1 111 10
TAK1 11 2
IRAK1 81 14
IRAK4 99 13
RIPK2 103 4
OSR1 54 0
TTK 91 10
MPSK1 103 1
Src 66 3
Lck 13 2
CSK 82 3
YES1 53 6
ABL 51 1
BTK 103 15
JAK2 93 12
SYK 103 2
ZAP70 92 10
TIE2 95 1
BRK 101 10
EPH-A2 74 5
EPH-A4 96 7
EPH-B1 111 8
EPH-B2 88 21
EPH-B3 97 7
EPH-B4 97 2
FGF-R1 79 1
HER4 105 3
IGF-1R 107 12
IR 86 9
IRR 112 5
TrkA 111 5
VEGFR1 70 7

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