Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
OSU-03012 C26H19F3N4O 460.45 PDK1 Zhu J. (2004) Cancer Res. 64(12) 4309-18 Selleck Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 107 7
MKK2 113 14
MKK6 74 4
ERK1 63 1
ERK2 88 13
ERK5 89 1
JNK1 103 3
JNK2 96 8
JNK3 86 10
p38 alpha MAPK 80 4
p38 beta MAPK 95 7
p38 gamma MAPK 70 1
p38 delta MAPK 70 2
ERK8 75 4
RSK1 63 9
RSK2 98 60
PDK1 77 7
PKB alpha 53 0
PKB beta 54 2
SGK1 30 1
S6K1 21 7
PKA 93 10
ROCK 2 87 8
PRK2 63 3
PKC alpha 90 9
PKC gamma 97 0
PKC zeta 61 3
PKD1 93 10
STK33 92 9
MSK1 46 3
MNK1 83 0
MNK2 109 17
MAPKAP-K2 95 2
MAPKAP-K3 97 1
PRAK 76 11
CAMKK beta 115 4
CAMK1 21 0
SmMLCK 42 30
PHK 72 0
DAPK1 43 8
CHK1 44 4
CHK2 76 14
GSK3 beta 119 4
CDK2-Cyclin A 95 2
CDK9-Cyclin T1 83 3
PLK1 111 11
Aurora A 107 13
Aurora B 88 3
TLK1 104 14
LKB1 99 3
AMPK 105 10
AMPK (hum) 94 11
MARK1 79 3
MARK2 89 7
MARK3 101 2
MARK4 102 9
BRSK1 89 6
BRSK2 64 3
MELK 75 5
NUAK1 61 4
SIK2 79 3
SIK3 101 1
TSSK1 83 15
CK1 gamma 2 90 7
CK1 delta 93 12
CK2 79 11
TTBK1 129 28
TTBK2 154 2
DYRK1A 82 18
DYRK2 121 4
DYRK3 105 21
NEK2a 92 8
NEK6 63 0
IKK beta 88 3
IKK epsilon 101 2
TBK1 83 7
PIM1 94 2
PIM2 98 4
PIM3 64 2
SRPK1 80 3
EF2K 75 18
EIF2AK3 95 20
HIPK1 90 19
HIPK2 69 14
HIPK3 64 3
CLK2 64 7
PAK2 75 7
PAK4 70 1
PAK5 107 9
PAK6 28 1
MST2 81 15
MST3 70 6
MST4 72 3
GCK 92 9
MAP4K3 73 19
MAP4K5 73 0
MINK1 47 7
MEKK1 103 3
MLK1 80 2
MLK3 87 9
TESK1 103 6
TAO1 92 7
ASK1 83 0
TAK1 36 11
IRAK1 80 11
IRAK4 79 8
RIPK2 81 13
OSR1 106 26
TTK 86 1
MPSK1 97 20
WNK1 105 1
ULK1 97 14
ULK2 101 22
TGFBR1 98 0
Src 135 15
Lck 247 13
CSK 85 13
YES1 80 2
ABL 103 6
BTK 96 11
JAK2 116 27
SYK 85 2
ZAP70 83 19
TIE2 105 24
BRK 91 3
EPH-A2 94 2
EPH-A4 91 2
EPH-B1 67 9
EPH-B2 91 4
EPH-B3 82 9
EPH-B4 88 21
FGF-R1 128 20
HER4 104 7
IGF-1R 105 4
IR 94 2
IRR 75 12
TrkA 90 3
DDR2 101 8
VEGFR1 89 9
PDGFRA 98 8
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 108 1
MKK2 123 10
MKK6 82 4
ERK1 80 11
ERK2 101 16
ERK5 91 2
JNK1 107 11
JNK2 102 8
JNK3 85 2
p38 alpha MAPK 100 0
p38 beta MAPK 92 10
p38 gamma MAPK 94 7
p38 delta MAPK 96 11
ERK8 79 4
RSK1 87 9
RSK2 80 23
PDK1 79 6
PKB alpha 91 16
PKB beta 87 8
SGK1 71 2
S6K1 86 13
PKA 100 12
ROCK 2 88 7
PRK2 85 1
PKC alpha 94 1
PKC gamma 95 3
PKC zeta 94 3
PKD1 86 9
STK33 91 2
MSK1 110 10
MNK1 86 2
MNK2 91 11
MAPKAP-K2 91 1
MAPKAP-K3 103 6
PRAK 89 6
CAMKK beta 120 26
CAMK1 109 7
SmMLCK 109 6
PHK 79 15
DAPK1 95 4
CHK1 72 10
CHK2 98 22
GSK3 beta 110 2
CDK2-Cyclin A 95 1
CDK9-Cyclin T1 82 0
PLK1 95 6
Aurora A 95 19
Aurora B 93 3
TLK1 89 3
LKB1 103 3
AMPK 99 1
AMPK (hum) 88 1
MARK1 87 2
MARK2 94 7
MARK3 96 3
MARK4 88 5
BRSK1 83 5
BRSK2 76 14
MELK 92 2
NUAK1 85 4
SIK2 95 6
SIK3 91 4
TSSK1 102 20
CK1 gamma 2 93 5
CK1 delta 96 14
CK2 111 2
TTBK1 88 6
TTBK2 96 8
DYRK1A 105 27
DYRK2 89 1
DYRK3 108 6
NEK2a 96 9
NEK6 115 7
IKK beta 87 3
IKK epsilon 114 33
TBK1 120 31
PIM1 92 8
PIM2 93 4
PIM3 99 11
SRPK1 94 2
EF2K 103 24
EIF2AK3 102 3
HIPK1 104 4
HIPK2 88 5
HIPK3 94 3
CLK2 93 6
PAK2 107 6
PAK4 84 1
PAK5 87 7
PAK6 88 3
MST2 106 18
MST3 84 8
MST4 80 8
GCK 107 11
MAP4K3 84 14
MAP4K5 80 1
MINK1 78 6
MEKK1 93 6
MLK1 99 10
MLK3 94 11
TESK1 84 7
TAO1 103 5
ASK1 86 2
TAK1 74 7
IRAK1 98 20
IRAK4 84 7
RIPK2 93 9
OSR1 95 4
TTK 90 9
MPSK1 100 24
WNK1 119 21
ULK1 86 3
ULK2 83 21
TGFBR1 98 7
Src 103 18
Lck 84 3
CSK 97 12
YES1 85 13
ABL 95 11
BTK 98 0
JAK2 101 0
SYK 87 21
ZAP70 84 3
TIE2 103 13
BRK 91 2
EPH-A2 92 9
EPH-A4 80 15
EPH-B1 72 3
EPH-B2 82 19
EPH-B3 72 2
EPH-B4 116 6
FGF-R1 111 17
HER4 106 11
IGF-1R 100 23
IR 98 0
IRR 91 3
TrkA 90 5
DDR2 92 0
VEGFR1 79 16
PDGFRA 82 1

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