Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BI605906 (BIX02514) C17H22F2N4O3S2 432.51 IKKβ Clark K. (2011) Biochem. J. 434 93-104 Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort ascending Standard Deviation
NEK6 130 0
PKC gamma 130 7
MEKK1 126 4
TAO1 124 13
PKD1 123 2
MKK1 120 8
PKB beta 120 10
EPH-B3 117 8
TrkA 115 11
EPH-B1 114 8
MLK3 114 12
RSK1 113 12
RSK2 113 10
PAK6 113 2
MPSK1 113 6
Aurora A 112 6
CSK 112 6
EPH-A4 110 5
BRSK2 110 12
MNK2 109 3
JNK2 109 2
EIF2AK3 109 4
TAK1 109 8
ERK1 108 8
MARK4 108 12
BTK 108 1
SYK 108 3
GSK3 beta 108 5
TIE2 108 2
EPH-A2 106 6
LKB1 106 5
Src 106 11
HIPK1 106 10
p38 delta MAPK 105 2
PAK2 105 5
ERK2 105 2
PHK 105 4
BRSK1 105 7
EF2K 105 7
MKK6 104 2
Lck 104 2
MELK 104 0
CHK2 104 2
PLK1 103 2
BRK 103 2
TBK1 103 15
ZAP70 103 1
ERK8 102 7
MSK1 102 4
CLK2 102 1
PAK5 102 8
EPH-B2 102 7
ABL 102 10
SRPK1 102 1
MAPKAP-K2 101 18
SGK1 101 10
CHK1 101 2
DYRK1A 100 6
EPH-B4 100 10
HIPK2 100 13
TTK 99 7
MST4 99 3
S6K1 99 5
STK33 98 6
DYRK2 98 11
OSR1 98 4
IKK epsilon 98 14
CAMK1 98 6
MLK1 98 8
NEK2a 97 3
MKK2 97 13
HIPK3 96 7
IRAK4 96 6
Aurora B 96 4
MARK3 96 8
PIM2 96 2
HER4 95 8
AMPK 94 8
MARK1 94 15
JNK3 94 9
JAK2 93 13
NUAK1 93 14
p38 beta MAPK 93 4
MAPKAP-K3 92 9
ASK1 92 4
TLK1 91 13
MINK1 91 0
PAK4 90 6
MST2 90 1
CAMKK beta 89 13
YES1 89 12
PKA 88 3
VEGFR1 88 0
CDK2-Cyclin A 88 6
GCK 87 3
PRK2 87 5
PKC alpha 87 2
PKC zeta 87 5
SmMLCK 86 6
ROCK 2 86 10
DAPK1 86 9
PKB alpha 85 14
MARK2 85 2
JNK1 85 5
p38 gamma MAPK 85 0
IRAK1 84 9
CK2 84 14
p38 alpha MAPK 83 0
DYRK3 82 1
FGF-R1 82 2
PIM1 82 4
PDK1 81 4
IR 80 1
CK1 delta 80 2
MNK1 76 8
RIPK2 76 2
PRAK 75 16
PIM3 74 9
IGF-1R 62 7
IRR 57 1
IKK beta 16 2
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort ascending Standard Deviation
JNK3 118 7
MEKK1 115 1
MSK1 115 14
RSK1 112 6
MKK1 110 11
TrkA 109 2
MAPKAP-K2 109 9
Lck 108 10
YES1 108 6
MELK 106 5
Aurora A 106 9
EIF2AK3 104 11
RSK2 104 8
NEK6 104 1
ZAP70 102 8
PHK 101 3
PKC gamma 101 8
EPH-B3 101 6
PRAK 101 6
TBK1 100 21
ROCK 2 100 4
TAK1 100 1
DYRK1A 100 2
CLK2 100 4
PKB beta 100 1
BRK 99 2
FGF-R1 98 7
CSK 98 13
PRK2 98 3
IRAK4 98 7
Aurora B 98 10
NEK2a 98 10
OSR1 98 9
HER4 97 2
IR 97 4
DAPK1 97 13
HIPK1 97 7
EPH-A4 97 3
MNK2 97 4
EPH-B2 97 4
PIM1 96 11
BRSK1 96 4
EF2K 96 9
MLK3 96 1
CHK2 96 3
p38 beta MAPK 96 13
GSK3 beta 96 7
HIPK3 96 3
DYRK2 96 1
PAK2 96 4
RIPK2 96 7
EPH-B1 96 5
TTK 96 11
CAMK1 95 7
JNK2 95 1
SRPK1 95 13
MLK1 95 1
EPH-B4 95 1
MARK3 94 7
PKC alpha 94 3
ASK1 94 8
PLK1 94 4
TLK1 94 10
MPSK1 94 0
CAMKK beta 93 12
PAK4 93 10
PAK6 93 3
MKK2 93 6
MST4 92 11
IGF-1R 92 1
ABL 92 12
BTK 92 9
p38 gamma MAPK 92 5
CDK2-Cyclin A 92 0
p38 delta MAPK 92 4
LKB1 92 4
PAK5 92 7
AMPK 92 15
MARK2 91 11
CHK1 91 11
p38 alpha MAPK 91 6
HIPK2 91 4
ERK2 90 5
PKD1 90 1
SGK1 89 5
BRSK2 89 8
TAO1 89 4
EPH-A2 89 3
PKB alpha 89 5
SmMLCK 88 5
MNK1 88 6
MKK6 87 8
PIM2 87 4
PKC zeta 87 5
TIE2 87 1
DYRK3 87 4
SYK 86 11
CK2 86 5
STK33 86 0
S6K1 85 5
MINK1 85 12
PIM3 85 3
PDK1 85 12
MAPKAP-K3 85 6
PKA 84 7
IRR 84 1
ERK8 84 9
MARK1 84 3
MST2 84 11
JAK2 83 0
GCK 81 4
MARK4 81 11
NUAK1 81 10
VEGFR1 81 3
Src 81 4
IRAK1 80 1
ERK1 78 3
JNK1 78 15
CK1 delta 78 0
IKK epsilon 75 3
IKK beta 33 0

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