Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BI605906 (BIX02514) C17H22F2N4O3S2 432.51 IKKβ Clark K. (2011) Biochem. J. 434 93-104 Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 110 11
MKK2 93 6
MKK6 87 8
ERK1 78 3
ERK2 90 5
JNK1 78 15
JNK2 95 1
JNK3 118 7
p38 alpha MAPK 91 6
p38 beta MAPK 96 13
p38 gamma MAPK 92 5
p38 delta MAPK 92 4
ERK8 84 9
RSK1 112 6
RSK2 104 8
PDK1 85 12
PKB alpha 89 5
PKB beta 100 1
SGK1 89 5
S6K1 85 5
PKA 84 7
ROCK 2 100 4
PRK2 98 3
PKC alpha 94 3
PKC gamma 101 8
PKC zeta 87 5
PKD1 90 1
STK33 86 0
MSK1 115 14
MNK1 88 6
MNK2 97 4
MAPKAP-K2 109 9
MAPKAP-K3 85 6
PRAK 101 6
CAMKK beta 93 12
CAMK1 95 7
SmMLCK 88 5
PHK 101 3
DAPK1 97 13
CHK1 91 11
CHK2 96 3
GSK3 beta 96 7
CDK2-Cyclin A 92 0
PLK1 94 4
Aurora A 106 9
Aurora B 98 10
TLK1 94 10
LKB1 92 4
AMPK 92 15
MARK1 84 3
MARK2 91 11
MARK3 94 7
MARK4 81 11
BRSK1 96 4
BRSK2 89 8
MELK 106 5
NUAK1 81 10
CK1 delta 78 0
CK2 86 5
DYRK1A 100 2
DYRK2 96 1
DYRK3 87 4
NEK2a 98 10
NEK6 104 1
IKK beta 33 0
IKK epsilon 75 3
TBK1 100 21
PIM1 96 11
PIM2 87 4
PIM3 85 3
SRPK1 95 13
EF2K 96 9
EIF2AK3 104 11
HIPK1 97 7
HIPK2 91 4
HIPK3 96 3
CLK2 100 4
PAK2 96 4
PAK4 93 10
PAK5 92 7
PAK6 93 3
MST2 84 11
MST4 92 11
GCK 81 4
MINK1 85 12
MEKK1 115 1
MLK1 95 1
MLK3 96 1
TAO1 89 4
ASK1 94 8
TAK1 100 1
IRAK1 80 1
IRAK4 98 7
RIPK2 96 7
OSR1 98 9
TTK 96 11
MPSK1 94 0
Src 81 4
Lck 108 10
CSK 98 13
YES1 108 6
ABL 92 12
BTK 92 9
JAK2 83 0
SYK 86 11
ZAP70 102 8
TIE2 87 1
BRK 99 2
EPH-A2 89 3
EPH-A4 97 3
EPH-B1 96 5
EPH-B2 97 4
EPH-B3 101 6
EPH-B4 95 1
FGF-R1 98 7
HER4 97 2
IGF-1R 92 1
IR 97 4
IRR 84 1
TrkA 109 2
VEGFR1 81 3
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 120 8
MKK2 97 13
MKK6 104 2
ERK1 108 8
ERK2 105 2
JNK1 85 5
JNK2 109 2
JNK3 94 9
p38 alpha MAPK 83 0
p38 beta MAPK 93 4
p38 gamma MAPK 85 0
p38 delta MAPK 105 2
ERK8 102 7
RSK1 113 12
RSK2 113 10
PDK1 81 4
PKB alpha 85 14
PKB beta 120 10
SGK1 101 10
S6K1 99 5
PKA 88 3
ROCK 2 86 10
PRK2 87 5
PKC alpha 87 2
PKC gamma 130 7
PKC zeta 87 5
PKD1 123 2
STK33 98 6
MSK1 102 4
MNK1 76 8
MNK2 109 3
MAPKAP-K2 101 18
MAPKAP-K3 92 9
PRAK 75 16
CAMKK beta 89 13
CAMK1 98 6
SmMLCK 86 6
PHK 105 4
DAPK1 86 9
CHK1 101 2
CHK2 104 2
GSK3 beta 108 5
CDK2-Cyclin A 88 6
PLK1 103 2
Aurora A 112 6
Aurora B 96 4
TLK1 91 13
LKB1 106 5
AMPK 94 8
MARK1 94 15
MARK2 85 2
MARK3 96 8
MARK4 108 12
BRSK1 105 7
BRSK2 110 12
MELK 104 0
NUAK1 93 14
CK1 delta 80 2
CK2 84 14
DYRK1A 100 6
DYRK2 98 11
DYRK3 82 1
NEK2a 97 3
NEK6 130 0
IKK beta 16 2
IKK epsilon 98 14
TBK1 103 15
PIM1 82 4
PIM2 96 2
PIM3 74 9
SRPK1 102 1
EF2K 105 7
EIF2AK3 109 4
HIPK1 106 10
HIPK2 100 13
HIPK3 96 7
CLK2 102 1
PAK2 105 5
PAK4 90 6
PAK5 102 8
PAK6 113 2
MST2 90 1
MST4 99 3
GCK 87 3
MINK1 91 0
MEKK1 126 4
MLK1 98 8
MLK3 114 12
TAO1 124 13
ASK1 92 4
TAK1 109 8
IRAK1 84 9
IRAK4 96 6
RIPK2 76 2
OSR1 98 4
TTK 99 7
MPSK1 113 6
Src 106 11
Lck 104 2
CSK 112 6
YES1 89 12
ABL 102 10
BTK 108 1
JAK2 93 13
SYK 108 3
ZAP70 103 1
TIE2 108 2
BRK 103 2
EPH-A2 106 6
EPH-A4 110 5
EPH-B1 114 8
EPH-B2 102 7
EPH-B3 117 8
EPH-B4 100 10
FGF-R1 82 2
HER4 95 8
IGF-1R 62 7
IR 80 1
IRR 57 1
TrkA 115 11
VEGFR1 88 0

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