Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Cot-Tpl2 Inhibitor Compound 10b (Abbott) C20H15N3OS 345.42 Cot-Tpl2 Cusack K. (2009) Bioorganic and MedicinalChemistry Letters 19 1722-1725 Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort ascending Standard Deviation
NEK6 135 13
BRSK2 130 3
EF2K 117 10
PKB alpha 108 4
Src 108 7
PDK1 100 12
CK2 100 12
MNK1 99 4
PKB beta 98 4
PLK1 97 5
PKA 96 3
MAPKAP-K2 94 8
EPH-B3 92 5
Aurora A 89 2
BRSK1 89 8
DYRK2 88 5
EPH-A2 86 4
FGF-R1 85 6
PAK2 84 3
PKC zeta 82 3
PIM2 81 4
p38 beta MAPK 80 5
EPH-A4 71 9
MSK1 70 9
MAPKAP-K3 69 2
AMPK 68 3
Lck 67 9
MNK2 66 6
IKK beta 65 2
DYRK3 59 5
p38 alpha MAPK 59 4
CSK 58 2
SYK 56 2
PHK 55 1
RSK2 53 0
TBK1 47 7
MARK4 46 2
SGK1 46 2
JNK3 46 8
NEK2a 44 3
IRAK4 44 10
Aurora B 43 1
JAK2 43 6
PIM3 42 4
PIM1 41 4
S6K1 39 0
p38 gamma MAPK 38 0
CAMK1 38 1
MARK1 37 6
p38 delta MAPK 36 1
MST4 35 0
CDK2-Cyclin A 35 1
JNK2 33 0
PAK6 31 1
RSK1 31 3
IKK epsilon 31 1
BTK 30 11
CAMKK beta 30 3
MEKK1 30 0
CHK1 29 1
PRK2 29 9
TrkA 28 4
MARK2 28 2
MARK3 26 3
EPH-B2 24 1
TTK 24 1
ERK8 23 1
LKB1 23 2
VEGFR1 22 1
MST2 21 3
EPH-B4 19 2
HIPK3 19 2
CHK2 18 10
CK1 delta 18 3
PKC alpha 18 2
IR 18 4
MKK1 17 2
SmMLCK 17 1
SRPK1 17 1
HER4 17 1
PAK5 16 0
ERK1 16 1
IRR 16 2
PRAK 15 6
MELK 15 1
JNK1 15 1
YES1 13 4
HIPK1 13 4
IGF-1R 13 1
RIPK2 12 1
PKD1 11 1
DAPK1 10 3
HIPK2 9 4
PAK4 7 0
ROCK 2 7 0
MLK1 6 1
ERK2 6 0
NUAK1 6 0
GCK 5 2
DYRK1A 5 1
MINK1 4 0
MLK3 4 0
GSK3 beta 4 0
TAK1 2 0
CLK2 2 0
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort ascending Standard Deviation
EPH-B3 128 4
IRAK4 127 9
EF2K 124 18
BTK 120 33
YES1 115 22
ERK1 114 20
IGF-1R 113 2
PIM1 112 1
S6K1 112 3
JNK1 111 1
Aurora B 110 1
PDK1 110 3
p38 alpha MAPK 110 5
MNK2 109 26
IKK epsilon 109 2
BRSK2 109 7
CK1 delta 109 3
NEK6 108 4
MST2 108 13
RSK2 108 6
MEKK1 108 3
PKC zeta 108 3
PLK1 108 3
MNK1 107 12
CAMK1 107 9
EPH-B4 107 13
JNK2 107 12
LKB1 105 5
PKB alpha 105 9
Lck 105 9
MARK3 104 4
PHK 104 5
FGF-R1 104 2
HER4 104 25
CHK2 104 6
MARK2 103 4
IR 103 1
MAPKAP-K2 102 9
MST4 102 12
BRSK1 102 1
JAK2 101 2
PIM3 101 4
DYRK2 101 4
CHK1 100 12
PRK2 100 1
Src 100 11
PAK2 100 5
VEGFR1 100 8
ERK8 99 6
AMPK 99 1
CAMKK beta 99 0
MELK 99 13
TBK1 98 5
PIM2 98 3
SmMLCK 98 4
JNK3 97 14
CDK2-Cyclin A 97 11
DYRK3 97 0
IKK beta 96 3
SYK 96 2
p38 beta MAPK 96 5
Aurora A 95 0
PKB beta 94 1
PKC alpha 94 9
MAPKAP-K3 93 3
EPH-A4 93 16
p38 gamma MAPK 93 9
RSK1 92 2
SGK1 92 16
TrkA 92 5
CK2 91 1
EPH-B2 90 5
MKK1 90 10
MSK1 90 32
CSK 90 3
NEK2a 88 12
MARK4 88 5
PRAK 87 9
EPH-A2 87 15
SRPK1 87 10
TTK 87 11
HIPK1 86 4
RIPK2 86 14
PAK6 85 2
p38 delta MAPK 83 1
ERK2 81 4
NUAK1 81 6
PKA 80 16
PAK5 79 4
MARK1 78 15
DAPK1 76 8
HIPK3 76 14
ROCK 2 75 10
MLK3 74 5
DYRK1A 72 4
TAK1 71 36
GSK3 beta 68 6
IRR 66 8
PKD1 66 7
PAK4 65 5
HIPK2 64 2
MINK1 58 5
MLK1 54 3
CLK2 50 4
GCK 7 1
Screening Concentration: 1µM
Kinase % Activity Remainingsort ascending Standard Deviation
EF2K 114 13
MNK1 114 9
EPH-B3 113 1
JNK3 112 43
p38 beta MAPK 111 10
BRSK2 108 7
PDK1 107 3
PKB alpha 104 4
PKA 103 11
p38 alpha MAPK 101 17
MAPKAP-K2 101 5
Aurora A 99 9
PLK1 98 8
NEK6 98 2
MSK1 97 10
FGF-R1 96 2
Aurora B 96 5
AMPK 95 5
PIM2 95 13
CK2 94 0
BTK 94 10
PKC zeta 93 3
PAK2 93 7
PHK 92 3
IRAK4 92 7
MNK2 91 7
TBK1 91 9
S6K1 90 11
JAK2 90 11
CAMK1 90 12
Src 89 4
PIM1 89 2
EPH-A4 89 3
PIM3 88 0
Lck 88 4
SYK 88 5
PKB beta 88 2
IGF-1R 87 2
CDK2-Cyclin A 87 10
MKK1 86 8
IKK epsilon 86 3
RSK2 84 12
MAPKAP-K3 84 2
JNK2 82 6
CSK 82 13
MARK4 82 5
BRSK1 81 0
IR 81 1
IKK beta 81 11
EPH-A2 78 12
DYRK2 77 5
p38 delta MAPK 77 6
EPH-B4 76 13
PRK2 76 1
p38 gamma MAPK 76 5
DYRK3 76 1
MST4 75 2
NEK2a 74 6
EPH-B2 74 2
CK1 delta 73 1
TrkA 73 14
MEKK1 73 3
PAK6 70 10
JNK1 69 0
MARK3 69 1
SRPK1 67 12
YES1 66 4
MARK1 66 5
RSK1 65 3
MARK2 65 4
CHK1 64 2
PKC alpha 64 12
CAMKK beta 61 5
MST2 59 2
SGK1 58 4
ERK1 58 8
MELK 57 7
LKB1 57 7
TTK 55 4
VEGFR1 55 10
SmMLCK 53 0
HIPK3 52 8
ERK8 50 10
PRAK 42 8
DAPK1 40 2
HER4 40 5
HIPK1 37 2
CHK2 37 3
PAK5 37 3
RIPK2 36 3
ERK2 35 4
ROCK 2 31 5
IRR 26 2
NUAK1 24 5
HIPK2 22 2
DYRK1A 21 1
PKD1 21 3
MLK3 19 0
MLK1 18 1
PAK4 18 1
GSK3 beta 16 6
MINK1 12 0
CLK2 10 0
TAK1 8 0
GCK 6 1

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