Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Cot-Tpl2 Inhibitor Compound 10b (Abbott) C20H15N3OS 345.42 Cot-Tpl2 Cusack K. (2009) Bioorganic and MedicinalChemistry Letters 19 1722-1725 Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 86 8
ERK1 58 8
ERK2 35 4
JNK1 69 0
JNK2 82 6
JNK3 112 43
p38 alpha MAPK 101 17
p38 beta MAPK 111 10
p38 gamma MAPK 76 5
p38 delta MAPK 77 6
ERK8 50 10
RSK1 65 3
RSK2 84 12
PDK1 107 3
PKB alpha 104 4
PKB beta 88 2
SGK1 58 4
S6K1 90 11
PKA 103 11
ROCK 2 31 5
PRK2 76 1
PKC alpha 64 12
PKC zeta 93 3
PKD1 21 3
MSK1 97 10
MNK1 114 9
MNK2 91 7
MAPKAP-K2 101 5
MAPKAP-K3 84 2
PRAK 42 8
CAMKK beta 61 5
CAMK1 90 12
SmMLCK 53 0
PHK 92 3
DAPK1 40 2
CHK1 64 2
CHK2 37 3
GSK3 beta 16 6
CDK2-Cyclin A 87 10
PLK1 98 8
Aurora A 99 9
Aurora B 96 5
LKB1 57 7
AMPK 95 5
MARK1 66 5
MARK2 65 4
MARK3 69 1
MARK4 82 5
BRSK1 81 0
BRSK2 108 7
MELK 57 7
NUAK1 24 5
CK1 delta 73 1
CK2 94 0
DYRK1A 21 1
DYRK2 77 5
DYRK3 76 1
NEK2a 74 6
NEK6 98 2
IKK beta 81 11
IKK epsilon 86 3
TBK1 91 9
PIM1 89 2
PIM2 95 13
PIM3 88 0
SRPK1 67 12
EF2K 114 13
HIPK1 37 2
HIPK2 22 2
HIPK3 52 8
CLK2 10 0
PAK2 93 7
PAK4 18 1
PAK5 37 3
PAK6 70 10
MST2 59 2
MST4 75 2
GCK 6 1
MINK1 12 0
MEKK1 73 3
MLK1 18 1
MLK3 19 0
TAK1 8 0
IRAK4 92 7
RIPK2 36 3
TTK 55 4
Src 89 4
Lck 88 4
CSK 82 13
YES1 66 4
BTK 94 10
JAK2 90 11
SYK 88 5
EPH-A2 78 12
EPH-A4 89 3
EPH-B2 74 2
EPH-B3 113 1
EPH-B4 76 13
FGF-R1 96 2
HER4 40 5
IGF-1R 87 2
IR 81 1
IRR 26 2
TrkA 73 14
VEGFR1 55 10
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 90 10
ERK1 114 20
ERK2 81 4
JNK1 111 1
JNK2 107 12
JNK3 97 14
p38 alpha MAPK 110 5
p38 beta MAPK 96 5
p38 gamma MAPK 93 9
p38 delta MAPK 83 1
ERK8 99 6
RSK1 92 2
RSK2 108 6
PDK1 110 3
PKB alpha 105 9
PKB beta 94 1
SGK1 92 16
S6K1 112 3
PKA 80 16
ROCK 2 75 10
PRK2 100 1
PKC alpha 94 9
PKC zeta 108 3
PKD1 66 7
MSK1 90 32
MNK1 107 12
MNK2 109 26
MAPKAP-K2 102 9
MAPKAP-K3 93 3
PRAK 87 9
CAMKK beta 99 0
CAMK1 107 9
SmMLCK 98 4
PHK 104 5
DAPK1 76 8
CHK1 100 12
CHK2 104 6
GSK3 beta 68 6
CDK2-Cyclin A 97 11
PLK1 108 3
Aurora A 95 0
Aurora B 110 1
LKB1 105 5
AMPK 99 1
MARK1 78 15
MARK2 103 4
MARK3 104 4
MARK4 88 5
BRSK1 102 1
BRSK2 109 7
MELK 99 13
NUAK1 81 6
CK1 delta 109 3
CK2 91 1
DYRK1A 72 4
DYRK2 101 4
DYRK3 97 0
NEK2a 88 12
NEK6 108 4
IKK beta 96 3
IKK epsilon 109 2
TBK1 98 5
PIM1 112 1
PIM2 98 3
PIM3 101 4
SRPK1 87 10
EF2K 124 18
HIPK1 86 4
HIPK2 64 2
HIPK3 76 14
CLK2 50 4
PAK2 100 5
PAK4 65 5
PAK5 79 4
PAK6 85 2
MST2 108 13
MST4 102 12
GCK 7 1
MINK1 58 5
MEKK1 108 3
MLK1 54 3
MLK3 74 5
TAK1 71 36
IRAK4 127 9
RIPK2 86 14
TTK 87 11
Src 100 11
Lck 105 9
CSK 90 3
YES1 115 22
BTK 120 33
JAK2 101 2
SYK 96 2
EPH-A2 87 15
EPH-A4 93 16
EPH-B2 90 5
EPH-B3 128 4
EPH-B4 107 13
FGF-R1 104 2
HER4 104 25
IGF-1R 113 2
IR 103 1
IRR 66 8
TrkA 92 5
VEGFR1 100 8
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 17 2
ERK1 16 1
ERK2 6 0
JNK1 15 1
JNK2 33 0
JNK3 46 8
p38 alpha MAPK 59 4
p38 beta MAPK 80 5
p38 gamma MAPK 38 0
p38 delta MAPK 36 1
ERK8 23 1
RSK1 31 3
RSK2 53 0
PDK1 100 12
PKB alpha 108 4
PKB beta 98 4
SGK1 46 2
S6K1 39 0
PKA 96 3
ROCK 2 7 0
PRK2 29 9
PKC alpha 18 2
PKC zeta 82 3
PKD1 11 1
MSK1 70 9
MNK1 99 4
MNK2 66 6
MAPKAP-K2 94 8
MAPKAP-K3 69 2
PRAK 15 6
CAMKK beta 30 3
CAMK1 38 1
SmMLCK 17 1
PHK 55 1
DAPK1 10 3
CHK1 29 1
CHK2 18 10
GSK3 beta 4 0
CDK2-Cyclin A 35 1
PLK1 97 5
Aurora A 89 2
Aurora B 43 1
LKB1 23 2
AMPK 68 3
MARK1 37 6
MARK2 28 2
MARK3 26 3
MARK4 46 2
BRSK1 89 8
BRSK2 130 3
MELK 15 1
NUAK1 6 0
CK1 delta 18 3
CK2 100 12
DYRK1A 5 1
DYRK2 88 5
DYRK3 59 5
NEK2a 44 3
NEK6 135 13
IKK beta 65 2
IKK epsilon 31 1
TBK1 47 7
PIM1 41 4
PIM2 81 4
PIM3 42 4
SRPK1 17 1
EF2K 117 10
HIPK1 13 4
HIPK2 9 4
HIPK3 19 2
CLK2 2 0
PAK2 84 3
PAK4 7 0
PAK5 16 0
PAK6 31 1
MST2 21 3
MST4 35 0
GCK 5 2
MINK1 4 0
MEKK1 30 0
MLK1 6 1
MLK3 4 0
TAK1 2 0
IRAK4 44 10
RIPK2 12 1
TTK 24 1
Src 108 7
Lck 67 9
CSK 58 2
YES1 13 4
BTK 30 11
JAK2 43 6
SYK 56 2
EPH-A2 86 4
EPH-A4 71 9
EPH-B2 24 1
EPH-B3 92 5
EPH-B4 19 2
FGF-R1 85 6
HER4 17 1
IGF-1R 13 1
IR 18 4
IRR 16 2
TrkA 28 4
VEGFR1 22 1

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