Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SB-747651A C16H22N8O 342.40 Naqvi (2012) Biochem. J. 441 (347–357) Axon Download

Results as Barchart

View results as a bar chart
1µM
10µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 103 0
MKK2 135 20
MKK6 90 1
ERK1 98 11
ERK2 117 3
ERK5 83 8
JNK1 105 5
JNK2 103 3
JNK3 109 29
p38 alpha MAPK 95 7
p38 beta MAPK 96 6
p38 gamma MAPK 112 3
p38 delta MAPK 99 1
ERK8 62 1
RSK1 15 5
RSK2 61 36
PDK1 95 17
PKB alpha 16 6
PKB beta 59 11
SGK1 55 3
S6K1 5 0
PKA 33 2
ROCK 2 23 1
PRK2 12 3
PKC alpha 70 0
PKC gamma 80 4
PKC zeta 71 1
PKD1 93 7
STK33 106 16
MSK1 5 0
MNK1 100 4
MNK2 116 8
MAPKAP-K2 104 4
MAPKAP-K3 101 2
PRAK 95 0
CAMKK beta 128 18
CAMK1 109 4
SmMLCK 110 8
PHK 101 16
DAPK1 84 4
CHK1 88 15
CHK2 89 1
GSK3 beta 66 2
CDK2-Cyclin A 81 1
CDK9-Cyclin T1 115 6
PLK1 60 3
Aurora A 95 3
Aurora B 76 8
TLK1 92 3
LKB1 94 20
AMPK 82 0
AMPK (hum) 78 8
MARK1 95 5
MARK2 92 2
MARK3 87 2
MARK4 103 17
BRSK1 81 4
BRSK2 89 7
MELK 40 6
NUAK1 91 3
SIK2 93 5
SIK3 94 6
TSSK1 88 22
CK1 gamma 2 92 4
CK1 delta 91 15
CK2 74 0
TTBK1 100 15
TTBK2 95 12
DYRK1A 73 6
DYRK2 89 3
DYRK3 93 14
NEK2a 93 6
NEK6 101 3
IKK beta 97 8
IKK epsilon 110 17
TBK1 93 13
PIM1 35 2
PIM2 110 5
PIM3 36 5
SRPK1 99 16
EF2K 119 29
EIF2AK3 105 10
HIPK1 107 5
HIPK2 82 3
HIPK3 95 1
CLK2 71 5
PAK2 93 2
PAK4 96 10
PAK5 100 9
PAK6 94 13
MST2 97 2
MST3 91 11
MST4 81 8
GCK 94 9
MAP4K3 110 32
MAP4K5 103 2
MINK1 96 5
MEKK1 93 2
MLK1 104 2
MLK3 111 12
TESK1 114 17
TAO1 108 7
ASK1 97 9
TAK1 94 8
IRAK1 103 9
IRAK4 86 4
RIPK2 77 5
OSR1 102 6
TTK 84 4
MPSK1 103 9
WNK1 102 5
ULK1 74 6
ULK2 98 5
TGFBR1 90 5
Src 120 6
Lck 99 7
CSK 95 7
YES1 98 3
ABL 109 9
BTK 93 3
JAK2 103 3
SYK 101 7
ZAP70 84 0
TIE2 116 2
BRK 99 20
EPH-A2 114 7
EPH-A4 109 19
EPH-B1 99 9
EPH-B2 91 1
EPH-B3 99 1
EPH-B4 105 17
FGF-R1 115 6
HER4 104 3
IGF-1R 107 2
IR 99 2
IRR 49 1
TrkA 99 2
DDR2 97 3
VEGFR1 105 1
PDGFRA 101 2
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 9
MKK2 98 14
MKK6 89 7
ERK1 95 4
ERK2 113 11
ERK5 96 3
JNK1 112 2
JNK2 109 2
JNK3 97 6
p38 alpha MAPK 101 0
p38 beta MAPK 102 3
p38 gamma MAPK 119 4
p38 delta MAPK 100 0
ERK8 95 9
RSK1 33 2
RSK2 94 11
PDK1 96 4
PKB alpha 48 1
PKB beta 101 16
SGK1 82 8
S6K1 16 3
PKA 79 1
ROCK 2 31 6
PRK2 31 0
PKC alpha 84 5
PKC gamma 96 9
PKC zeta 94 7
PKD1 86 1
STK33 104 6
MSK1 22 3
MNK1 91 3
MNK2 110 3
MAPKAP-K2 112 11
MAPKAP-K3 98 3
PRAK 94 4
CAMKK beta 121 20
CAMK1 119 11
SmMLCK 104 2
PHK 101 8
DAPK1 111 13
CHK1 89 2
CHK2 94 1
GSK3 beta 87 2
CDK2-Cyclin A 83 2
CDK9-Cyclin T1 103 6
PLK1 83 14
Aurora A 91 13
Aurora B 85 3
TLK1 92 3
LKB1 108 13
AMPK 95 10
AMPK (hum) 115 3
MARK1 85 9
MARK2 99 16
MARK3 88 2
MARK4 91 4
BRSK1 91 10
BRSK2 96 13
MELK 71 6
NUAK1 101 2
SIK2 97 2
SIK3 89 11
TSSK1 88 5
CK1 gamma 2 101 9
CK1 delta 102 2
CK2 71 7
TTBK1 104 14
TTBK2 91 7
DYRK1A 92 6
DYRK2 87 5
DYRK3 107 6
NEK2a 98 3
NEK6 103 9
IKK beta 98 5
IKK epsilon 111 18
TBK1 88 2
PIM1 94 12
PIM2 149 33
PIM3 76 2
SRPK1 94 9
EF2K 118 2
EIF2AK3 93 13
HIPK1 107 14
HIPK2 112 2
HIPK3 99 6
CLK2 107 5
PAK2 99 0
PAK4 105 37
PAK5 93 1
PAK6 103 4
MST2 106 12
MST3 86 7
MST4 91 7
GCK 91 2
MAP4K3 99 6
MAP4K5 107 6
MINK1 107 17
MEKK1 94 6
MLK1 105 16
MLK3 97 26
TESK1 103 10
TAO1 100 2
ASK1 100 4
TAK1 95 12
IRAK1 99 18
IRAK4 99 4
RIPK2 86 9
OSR1 107 5
TTK 83 0
MPSK1 108 30
WNK1 106 0
ULK1 83 1
ULK2 93 2
TGFBR1 85 18
Src 110 3
Lck 102 4
CSK 89 5
YES1 108 5
ABL 102 4
BTK 92 1
JAK2 108 2
SYK 106 3
ZAP70 83 15
TIE2 122 33
BRK 91 18
EPH-A2 119 4
EPH-A4 116 31
EPH-B1 92 0
EPH-B2 115 5
EPH-B3 81 6
EPH-B4 105 14
FGF-R1 101 2
HER4 112 8
IGF-1R 96 3
IR 99 1
IRR 71 3
TrkA 104 9
DDR2 108 2
VEGFR1 103 2
PDGFRA 120 4
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 78 5
MKK2 126 27
MKK6 96 10
ERK1 97 3
ERK2 115 4
ERK5 64 6
JNK1 101 9
JNK2 95 10
JNK3 95 11
p38 alpha MAPK 94 6
p38 beta MAPK 89 1
p38 gamma MAPK 109 9
p38 delta MAPK 88 7
ERK8 27 5
RSK1 9 2
RSK2 64 62
PDK1 73 2
PKB alpha 4 1
PKB beta 38 10
SGK1 25 2
S6K1 4 2
PKA 8 1
ROCK 2 17 14
PRK2 7 1
PKC alpha 30 5
PKC gamma 46 6
PKC zeta 25 5
PKD1 76 1
STK33 74 1
MSK1 1 1
MNK1 90 3
MNK2 77 4
MAPKAP-K2 102 4
MAPKAP-K3 97 14
PRAK 96 11
CAMKK beta 105 11
CAMK1 109 3
SmMLCK 70 3
PHK 75 5
DAPK1 35 2
CHK1 53 2
CHK2 69 5
GSK3 beta 25 3
CDK2-Cyclin A 56 2
CDK9-Cyclin T1 103 6
PLK1 41 3
Aurora A 103 1
Aurora B 71 3
TLK1 88 2
LKB1 57 0
AMPK 29 3
AMPK (hum) 34 7
MARK1 71 7
MARK2 63 11
MARK3 56 13
MARK4 81 0
BRSK1 41 0
BRSK2 41 6
MELK 26 6
NUAK1 59 7
SIK2 95 6
SIK3 89 10
TSSK1 42 11
CK1 gamma 2 92 0
CK1 delta 61 9
CK2 86 7
TTBK1 91 1
TTBK2 101 11
DYRK1A 35 10
DYRK2 53 5
DYRK3 72 12
NEK2a 106 17
NEK6 102 14
IKK beta 100 1
IKK epsilon 115 6
TBK1 78 0
PIM1 7 1
PIM2 69 14
PIM3 13 0
SRPK1 86 15
EF2K 117 16
EIF2AK3 94 4
HIPK1 84 5
HIPK2 43 4
HIPK3 84 12
CLK2 22 2
PAK2 90 3
PAK4 79 3
PAK5 98 0
PAK6 93 5
MST2 71 0
MST3 73 5
MST4 91 16
GCK 71 7
MAP4K3 66 7
MAP4K5 84 13
MINK1 72 5
MEKK1 112 13
MLK1 99 16
MLK3 89 5
TESK1 104 15
TAO1 104 18
ASK1 97 11
TAK1 82 3
IRAK1 75 1
IRAK4 87 17
RIPK2 77 8
OSR1 97 1
TTK 65 3
MPSK1 83 9
WNK1 100 11
ULK1 43 1
ULK2 73 4
TGFBR1 92 2
Src 102 17
Lck 94 10
CSK 98 3
YES1 86 8
ABL 96 3
BTK 112 9
JAK2 110 4
SYK 79 2
ZAP70 84 16
TIE2 111 4
BRK 91 17
EPH-A2 103 8
EPH-A4 103 25
EPH-B1 82 10
EPH-B2 87 3
EPH-B3 83 0
EPH-B4 94 12
FGF-R1 121 6
HER4 115 20
IGF-1R 105 2
IR 99 2
IRR 21 0
TrkA 97 1
DDR2 104 10
VEGFR1 83 9
PDGFRA 99 3

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