Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
SB-590885 C27H27N5O2 453.54 B-Raf King (2006) Cancer Res. 66 11100 Tocris Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 87 1
MKK2 95 1
MKK6 79 5
ERK1 80 16
ERK2 105 10
ERK5 82 0
JNK1 107 1
JNK2 97 6
JNK3 81 21
p38 alpha MAPK 90 6
p38 beta MAPK 111 5
p38 gamma MAPK 99 0
p38 delta MAPK 92 4
ERK8 90 1
RSK1 87 8
RSK2 80 5
PDK1 84 1
PKB alpha 89 2
PKB beta 96 16
SGK1 82 10
S6K1 95 26
PKA 102 7
ROCK 2 83 2
PRK2 93 5
PKC alpha 94 7
PKC gamma 93 1
PKC zeta 97 5
PKD1 83 5
STK33 87 3
MSK1 104 5
MNK1 87 5
MNK2 88 13
MAPKAP-K2 98 2
MAPKAP-K3 97 4
PRAK 95 14
CAMKK beta 101 23
CAMK1 103 4
SmMLCK 90 1
PHK 70 32
DAPK1 96 2
CHK1 85 14
CHK2 89 2
GSK3 beta 102 4
CDK2-Cyclin A 98 18
CDK9-Cyclin T1 71 4
PLK1 92 7
Aurora A 102 0
Aurora B 91 3
TLK1 94 3
LKB1 96 3
AMPK 110 3
AMPK (hum) 97 4
MARK1 76 1
MARK2 85 1
MARK3 91 2
MARK4 83 11
BRSK1 82 7
BRSK2 81 14
MELK 90 17
NUAK1 97 6
SIK2 81 14
SIK3 85 4
TSSK1 83 24
CK1 gamma 2 92 4
CK1 delta 90 1
CK2 81 7
TTBK1 97 13
TTBK2 87 3
DYRK1A 90 19
DYRK2 84 2
DYRK3 112 8
NEK2a 100 2
NEK6 82 7
IKK beta 87 3
IKK epsilon 89 8
TBK1 84 2
PIM1 103 8
PIM2 118 1
PIM3 99 0
SRPK1 97 2
EF2K 93 9
EIF2AK3 94 4
HIPK1 108 17
HIPK2 89 9
HIPK3 93 6
CLK2 85 4
PAK2 113 1
PAK4 93 1
PAK5 92 4
PAK6 92 1
MST2 98 8
MST3 94 0
MST4 85 10
GCK 106 7
MAP4K3 95 19
MAP4K5 96 16
MINK1 83 2
MEKK1 109 5
MLK1 105 9
MLK3 88 4
TESK1 81 4
TAO1 98 1
ASK1 83 3
TAK1 92 8
IRAK1 94 21
IRAK4 88 5
RIPK2 27 2
OSR1 94 8
TTK 86 7
MPSK1 95 12
WNK1 99 2
ULK1 98 16
ULK2 94 0
TGFBR1 95 6
Src 101 6
Lck 82 11
CSK 88 8
YES1 94 14
ABL 100 8
BTK 85 4
JAK2 101 3
SYK 96 6
ZAP70 77 33
TIE2 99 20
BRK 96 16
EPH-A2 84 14
EPH-A4 89 4
EPH-B1 71 6
EPH-B2 82 3
EPH-B3 85 1
EPH-B4 86 18
FGF-R1 115 20
HER4 85 5
IGF-1R 107 6
IR 87 4
IRR 89 1
TrkA 87 11
DDR2 104 8
VEGFR1 87 0
PDGFRA 83 3
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 89 4
MKK2 100 13
MKK6 120 8
ERK1 93 1
ERK2 101 14
ERK5 84 12
JNK1 105 9
JNK2 81 6
JNK3 94 2
p38 alpha MAPK 84 24
p38 beta MAPK 107 19
p38 gamma MAPK 92 10
p38 delta MAPK 92 3
ERK8 88 13
RSK1 92 7
RSK2 93 26
PDK1 109 23
PKB alpha 81 6
PKB beta 99 11
SGK1 76 0
S6K1 91 4
PKA 76 4
ROCK 2 48 11
PRK2 78 6
PKC alpha 97 18
PKC gamma 92 3
PKC zeta 94 1
PKD1 68 6
STK33 108 11
MSK1 84 15
MNK1 99 5
MNK2 127 5
MAPKAP-K2 93 0
MAPKAP-K3 87 7
PRAK 107 4
CAMKK beta 117 32
CAMK1 97 11
SmMLCK 67 4
PHK 96 12
DAPK1 100 5
CHK1 75 8
CHK2 76 2
GSK3 beta 84 10
CDK2-Cyclin A 112 9
CDK9-Cyclin T1 94 12
PLK1 77 7
Aurora A 98 7
Aurora B 78 3
TLK1 101 2
LKB1 111 1
AMPK 109 9
AMPK (hum) 105 23
MARK1 84 2
MARK2 96 11
MARK3 95 2
MARK4 97 8
BRSK1 93 1
BRSK2 85 1
MELK 82 14
NUAK1 90 5
SIK2 90 7
SIK3 83 8
TSSK1 92 2
CK1 gamma 2 95 3
CK1 delta 17 2
CK2 75 12
TTBK1 97 1
TTBK2 102 2
DYRK1A 81 1
DYRK2 75 12
DYRK3 91 9
NEK2a 91 1
NEK6 98 3
IKK beta 92 6
IKK epsilon 100 3
TBK1 93 1
PIM1 104 7
PIM2 90 10
PIM3 88 15
SRPK1 86 0
EF2K 122 20
EIF2AK3 79 5
HIPK1 66 6
HIPK2 62 9
HIPK3 92 1
CLK2 62 8
PAK2 105 9
PAK4 99 2
PAK5 89 10
PAK6 91 3
MST2 116 37
MST3 85 0
MST4 79 14
GCK 78 0
MAP4K3 81 19
MAP4K5 85 5
MINK1 30 5
MEKK1 95 6
MLK1 88 4
MLK3 89 9
TESK1 61 3
TAO1 102 5
ASK1 100 9
TAK1 83 10
IRAK1 84 13
IRAK4 95 1
RIPK2 20 4
OSR1 108 9
TTK 91 4
MPSK1 97 17
WNK1 105 5
ULK1 93 2
ULK2 113 12
TGFBR1 59 4
Src 104 7
Lck 29 5
CSK 130 11
YES1 73 24
ABL 47 3
BTK 83 4
JAK2 99 8
SYK 102 4
ZAP70 89 12
TIE2 45 6
BRK 28 7
EPH-A2 101 11
EPH-A4 74 10
EPH-B1 100 10
EPH-B2 86 4
EPH-B3 77 13
EPH-B4 110 18
FGF-R1 124 5
HER4 55 8
IGF-1R 89 8
IR 106 8
IRR 72 2
TrkA 85 9
DDR2 90 10
VEGFR1 77 6
PDGFRA 121 5
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 103 5
MKK2 80 5
MKK6 116 11
ERK1 110 21
ERK2 106 7
ERK5 119 4
JNK1 109 6
JNK2 110 1
JNK3 97 21
p38 alpha MAPK 99 1
p38 beta MAPK 102 7
p38 gamma MAPK 108 3
p38 delta MAPK 104 4
ERK8 95 4
RSK1 107 4
RSK2 105 4
PDK1 101 15
PKB alpha 102 15
PKB beta 103 5
SGK1 99 7
S6K1 107 8
PKA 101 8
ROCK 2 91 7
PRK2 98 7
PKC alpha 97 19
PKC gamma 105 11
PKC zeta 96 5
PKD1 97 15
STK33 116 11
MSK1 103 13
MNK1 106 6
MNK2 118 2
MAPKAP-K2 101 4
MAPKAP-K3 107 0
PRAK 101 1
CAMKK beta 141 4
CAMK1 112 6
SmMLCK 114 0
PHK 95 3
DAPK1 103 0
CHK1 90 3
CHK2 103 3
GSK3 beta 103 4
CDK2-Cyclin A 103 5
CDK9-Cyclin T1 100 12
PLK1 94 4
Aurora A 104 2
Aurora B 110 9
TLK1 100 8
LKB1 121 4
AMPK 112 2
AMPK (hum) 114 9
MARK1 97 5
MARK2 101 4
MARK3 94 5
MARK4 108 11
BRSK1 104 11
BRSK2 110 5
MELK 98 7
NUAK1 100 3
SIK2 93 2
SIK3 109 1
TSSK1 92 5
CK1 gamma 2 105 2
CK1 delta 58 2
CK2 82 19
TTBK1 111 9
TTBK2 106 13
DYRK1A 108 13
DYRK2 93 8
DYRK3 98 7
NEK2a 107 0
NEK6 102 6
IKK beta 105 4
IKK epsilon 106 24
TBK1 104 2
PIM1 99 3
PIM2 116 20
PIM3 102 6
SRPK1 100 10
EF2K 147 37
EIF2AK3 111 6
HIPK1 106 21
HIPK2 94 7
HIPK3 105 4
CLK2 107 18
PAK2 103 11
PAK4 104 2
PAK5 101 1
PAK6 99 5
MST2 126 18
MST3 102 7
MST4 96 7
GCK 106 11
MAP4K3 102 4
MAP4K5 116 31
MINK1 84 3
MEKK1 106 1
MLK1 99 7
MLK3 107 7
TESK1 100 10
TAO1 105 20
ASK1 110 0
TAK1 110 7
IRAK1 112 12
IRAK4 109 4
RIPK2 23 2
OSR1 108 9
TTK 102 6
MPSK1 106 16
WNK1 104 4
ULK1 100 6
ULK2 110 7
TGFBR1 102 4
Src 115 2
Lck 102 9
CSK 93 5
YES1 94 14
ABL 99 4
BTK 113 21
JAK2 117 7
SYK 106 1
ZAP70 102 11
TIE2 92 2
BRK 99 12
EPH-A2 115 5
EPH-A4 116 24
EPH-B1 104 0
EPH-B2 96 27
EPH-B3 90 4
EPH-B4 115 17
FGF-R1 106 2
HER4 92 1
IGF-1R 85 5
IR 107 9
IRR 93 4
TrkA 97 14
DDR2 102 1
VEGFR1 96 18
PDGFRA 130 16

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