Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PF4708671 C19H21F3N6 390.41 S6K1 Pearce (2010) Biochem.J. 431 245 Tocris Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 104 2
ERK1 85 9
ERK2 85 1
JNK1 107 6
JNK2 93 2
p38 alpha MAPK 79 12
p38 beta MAPK 89 10
p38 gamma MAPK 102 0
p38 delta MAPK 82 0
ERK8 83 16
RSK1 33 4
RSK2 67 8
PDK1 86 16
PKB alpha 69 5
PKB beta 73 2
SGK1 74 7
S6K1 16 2
PKA 83 1
ROCK 2 91 12
PRK2 86 7
PKC alpha 106 9
PKC zeta 75 19
PKD1 83 5
MSK1 34 2
MNK1 91 3
MNK2 93 10
MAPKAP-K2 105 3
PRAK 97 10
CAMKK beta 98 0
CAMK1 94 22
SmMLCK 79 3
PHK 96 10
CHK1 83 16
CHK2 73 17
GSK3 beta 96 8
CDK2-Cyclin A 101 10
PLK1 87 1
Aurora B 87 3
AMPK 88 3
MARK3 83 4
BRSK2 84 6
MELK 101 11
CK1 delta 93 3
CK2 92 2
DYRK1A 94 6
DYRK2 104 3
DYRK3 92 6
NEK2a 94 3
NEK6 75 2
IKK beta 119 11
IKK epsilon 99 1
TBK1 105 12
PIM1 90 4
PIM2 90 7
PIM3 88 8
SRPK1 106 15
EF2K 73 2
HIPK2 86 16
PAK4 88 3
PAK5 88 11
PAK6 83 9
MST2 85 5
MST4 77 5
Src 99 31
Lck 92 10
CSK 93 6
YES1 84 1
BTK 87 7
SYK 100 12
EPH-A2 86 5
EPH-B3 139 6
FGF-R1 92 2
IGF-1R 95 19
IR 95 5
IRR 96 14
VEGFR1 83 3
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 117 8
ERK1 93 16
ERK2 93 8
JNK1 111 34
JNK2 92 3
p38 alpha MAPK 86 3
p38 beta MAPK 88 7
p38 gamma MAPK 107 10
p38 delta MAPK 89 10
ERK8 85 1
RSK1 46 0
RSK2 86 3
PDK1 90 6
PKB alpha 87 2
PKB beta 74 7
SGK1 106 3
S6K1 39 8
PKA 84 0
ROCK 2 98 2
PRK2 95 1
PKC alpha 119 10
PKC zeta 78 8
PKD1 94 5
MSK1 80 6
MNK1 101 1
MNK2 92 2
MAPKAP-K2 88 22
PRAK 114 10
CAMKK beta 99 12
CAMK1 106 9
SmMLCK 95 9
PHK 100 7
CHK1 90 17
CHK2 101 3
GSK3 beta 87 5
CDK2-Cyclin A 102 21
PLK1 98 6
Aurora B 89 5
AMPK 100 0
MARK3 94 8
BRSK2 88 4
MELK 94 5
CK1 delta 96 7
CK2 96 10
DYRK1A 99 4
DYRK2 97 17
DYRK3 106 2
NEK2a 95 3
NEK6 88 4
IKK beta 104 2
IKK epsilon 103 6
TBK1 108 7
PIM1 88 2
PIM2 90 6
PIM3 93 2
SRPK1 108 11
EF2K 90 1
HIPK2 108 8
PAK4 93 7
PAK5 100 23
PAK6 99 3
MST2 95 3
MST4 87 4
Src 103 10
Lck 91 7
CSK 94 10
YES1 98 1
BTK 83 4
SYK 121 14
EPH-A2 95 12
EPH-B3 132 2
FGF-R1 91 1
IGF-1R 72 6
IR 108 5
IRR 88 8
VEGFR1 97 10
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 96 1
ERK1 83 28
ERK2 86 6
JNK1 95 0
JNK2 98 5
p38 alpha MAPK 86 5
p38 beta MAPK 97 11
p38 gamma MAPK 103 4
p38 delta MAPK 91 3
ERK8 71 9
RSK1 0 2
RSK2 25 7
PDK1 95 2
PKB alpha 52 5
PKB beta 60 2
SGK1 65 6
S6K1 6 2
PKA 34 10
ROCK 2 58 10
PRK2 84 3
PKC alpha 62 0
PKC zeta 70 16
PKD1 67 3
MSK1 6 0
MNK1 79 2
MNK2 79 11
MAPKAP-K2 78 13
PRAK 87 6
CAMKK beta 80 1
CAMK1 78 12
SmMLCK 87 16
PHK 104 7
CHK1 83 5
CHK2 72 6
GSK3 beta 92 2
CDK2-Cyclin A 88 8
PLK1 88 4
Aurora B 49 9
AMPK 46 1
MARK3 82 0
BRSK2 83 2
MELK 87 1
CK1 delta 71 2
CK2 83 12
DYRK1A 85 3
DYRK2 101 2
DYRK3 83 11
NEK2a 91 3
NEK6 80 11
IKK beta 102 3
IKK epsilon 96 5
TBK1 97 2
PIM1 78 6
PIM2 100 12
PIM3 83 2
SRPK1 101 16
EF2K 78 4
HIPK2 88 2
PAK4 88 7
PAK5 87 0
PAK6 86 4
MST2 77 3
MST4 46 3
Src 92 4
Lck 88 6
CSK 98 6
YES1 76 7
BTK 92 8
SYK 91 4
EPH-A2 89 15
EPH-B3 101 5
FGF-R1 63 1
IGF-1R 82 9
IR 96 8
IRR 77 16
VEGFR1 37 2

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