Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Torin1 C35H28F3N5O2 607.62 mTOR Liu Q. (2012) J Biol Chem. 287 9742-52 Tocris Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 22 6
ERK1 96 10
ERK2 90 4
JNK1 87 10
JNK2 84 3
JNK3 79 3
p38 alpha MAPK 99 6
p38 beta MAPK 78 3
p38 gamma MAPK 129 12
p38 delta MAPK 97 10
ERK8 46 7
RSK1 71 15
RSK2 81 10
PDK1 98 1
PKB alpha 71 6
PKB beta 84 1
SGK1 60 14
S6K1 81 1
PKA 96 7
ROCK 2 101 9
PRK2 114 6
PKC alpha 68 3
PKC zeta 106 7
PKD1 101 3
MSK1 62 6
MNK1 96 3
MNK2 96 7
MAPKAP-K2 108 5
MAPKAP-K3 105 10
PRAK 49 1
CAMKK beta 81 4
CAMK1 77 15
SmMLCK 83 1
PHK 99 6
CHK1 125 9
CHK2 83 4
GSK3 beta 49 1
CDK2-Cyclin A 77 6
PLK1 84 12
Aurora A 68 9
Aurora B 90 1
LKB1 80 0
AMPK 93 6
MARK2 102 23
MARK3 98 8
MARK4 97 5
BRSK1 94 17
BRSK2 104 7
MELK 17 3
NUAK1 79 12
CK1 delta 104 0
CK2 95 0
DYRK1A 75 0
DYRK2 99 16
DYRK3 52 3
NEK2a 99 4
NEK6 69 11
IKK beta 63 0
IKK epsilon 85 7
TBK1 87 5
PIM1 24 3
PIM2 96 4
PIM3 30 0
SRPK1 110 4
EF2K 111 7
HIPK1 85 15
HIPK2 88 6
HIPK3 91 4
PAK2 82 5
PAK4 66 6
PAK5 61 20
PAK6 80 0
MST2 79 3
MST4 89 7
GCK 25 1
MINK1 14 1
MLK1 48 4
MLK3 86 3
IRAK4 76 3
RIPK2 64 2
TTK 71 1
Src 52 5
Lck 78 4
CSK 83 4
YES1 78 3
BTK 56 0
SYK 68 2
EPH-A2 87 0
EPH-B3 94 6
FGF-R1 79 8
HER4 111 5
IGF-1R 93 1
IR 87 10
IRR 73 7
VEGFR1 84 6
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 69 11
ERK1 99 8
ERK2 102 4
JNK1 98 21
JNK2 98 10
JNK3 99 27
p38 alpha MAPK 95 4
p38 beta MAPK 83 5
p38 gamma MAPK 103 4
p38 delta MAPK 106 4
ERK8 78 4
RSK1 93 11
RSK2 96 14
PDK1 100 1
PKB alpha 94 6
PKB beta 95 0
SGK1 79 5
S6K1 97 13
PKA 106 9
ROCK 2 96 19
PRK2 97 1
PKC alpha 83 4
PKC zeta 121 13
PKD1 117 7
MSK1 86 5
MNK1 93 10
MNK2 112 2
MAPKAP-K2 102 4
MAPKAP-K3 113 3
PRAK 118 20
CAMKK beta 95 2
CAMK1 104 23
SmMLCK 94 5
PHK 110 10
CHK1 106 9
CHK2 90 2
GSK3 beta 79 6
CDK2-Cyclin A 108 4
PLK1 94 16
Aurora A 88 4
Aurora B 107 2
LKB1 96 3
AMPK 78 3
MARK2 117 10
MARK3 99 1
MARK4 94 15
BRSK1 99 4
BRSK2 102 5
MELK 63 6
NUAK1 101 10
CK1 delta 93 15
CK2 89 1
DYRK1A 92 3
DYRK2 99 1
DYRK3 88 6
NEK2a 88 1
NEK6 100 14
IKK beta 109 5
TBK1 96 15
PIM1 82 4
PIM2 86 5
PIM3 85 2
SRPK1 107 8
EF2K 118 8
HIPK1 76 4
HIPK2 96 0
HIPK3 107 17
PAK2 93 3
PAK4 110 12
PAK5 120 33
PAK6 110 0
MST2 97 21
MST4 96 11
GCK 69 1
MINK1 69 2
MLK1 92 6
MLK3 99 5
IRAK4 112 7
RIPK2 81 2
TTK 79 3
Src 60 6
Lck 93 8
CSK 101 2
YES1 113 2
BTK 104 5
SYK 131 14
EPH-A2 120 4
EPH-B3 115 2
FGF-R1 110 8
HER4 110 11
IGF-1R 100 9
IR 93 8
IRR 85 3
VEGFR1 108 1

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