Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PF3644022 C21H18N4OS 374.46 MAPKAPK2 Mourey (2010) J.Pharmacol.Exp.Ther. 333 797 Tocris Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 69 4
MKK2 79 4
MKK6 91 0
ERK1 112 20
ERK2 81 16
JNK1 92 2
JNK2 107 9
JNK3 102 16
p38 alpha MAPK 83 2
p38 beta MAPK 117 10
p38 gamma MAPK 97 7
p38 delta MAPK 94 8
ERK8 38 5
RSK1 76 2
RSK2 50 10
PDK1 95 12
PKB alpha 98 4
PKB beta 69 1
SGK1 112 17
S6K1 80 2
PKA 108 6
ROCK 2 95 2
PRK2 81 0
PKC alpha 90 6
PKC gamma 101 5
PKC zeta 106 8
PKD1 48 7
STK33 38 12
MSK1 99 5
MNK1 83 12
MNK2 26 7
MAPKAP-K2 2 1
MAPKAP-K3 30 10
PRAK 24 7
CAMKK beta 28 3
CAMK1 68 14
SmMLCK 110 7
PHK 86 5
DAPK1 15 2
CHK1 112 6
CHK2 9 8
GSK3 beta 88 4
CDK2-Cyclin A 57 9
CDK9-Cyclin T1 51 13
PLK1 98 8
Aurora A 84 4
Aurora B 64 8
TLK1 100 6
LKB1 97 7
AMPK 9 0
AMPK (hum) 6 0
MARK1 93 2
MARK2 95 1
MARK3 110 28
MARK4 49 11
BRSK1 29 0
BRSK2 8 2
MELK 77 7
NUAK1 58 4
SIK2 77 17
SIK3 73 14
TSSK1 89 1
CK1 gamma 2 102 3
CK1 delta 92 8
CK2 93 3
TTBK1 96 14
TTBK2 103 15
DYRK1A 8 0
DYRK2 52 1
DYRK3 40 4
NEK2a 88 14
NEK6 66 3
IKK beta 101 1
IKK epsilon 44 2
TBK1 96 10
PIM1 17 3
PIM2 66 9
PIM3 3 2
SRPK1 19 2
EF2K 85 1
EIF2AK3 73 0
HIPK1 130 8
HIPK2 78 4
HIPK3 96 14
CLK2 9 2
PAK2 93 10
PAK4 82 11
PAK5 101 2
PAK6 116 7
MST2 100 9
MST3 108 21
MST4 91 1
GCK 19 0
MAP4K3 41 0
MAP4K5 61 5
MINK1 40 0
MEKK1 109 6
MLK1 60 30
MLK3 73 1
TESK1 101 5
TAO1 70 2
ASK1 10 1
TAK1 70 7
IRAK1 27 2
IRAK4 24 5
RIPK2 39 18
OSR1 118 5
TTK 84 12
MPSK1 105 13
WNK1 119 3
ULK1 75 4
ULK2 54 4
Src 100 10
Lck 86 20
CSK 106 18
YES1 55 3
ABL 76 6
BTK 107 4
JAK2 79 1
SYK 82 10
ZAP70 95 21
TIE2 88 7
BRK 92 9
EPH-A2 76 5
EPH-A4 78 1
EPH-B1 106 2
EPH-B2 111 0
EPH-B3 85 2
EPH-B4 99 3
FGF-R1 68 14
HER4 99 2
IGF-1R 114 3
IR 133 40
IRR 53 16
TrkA 83 4
DDR2 91 8
VEGFR1 65 7
PDGFRA 104 51
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 97 15
MKK2 108 6
MKK6 98 22
ERK1 108 3
ERK2 84 25
JNK1 93 2
JNK2 111 6
JNK3 104 3
p38 alpha MAPK 94 7
p38 beta MAPK 126 3
p38 gamma MAPK 115 14
p38 delta MAPK 103 8
ERK8 79 10
RSK1 100 2
RSK2 79 11
PDK1 107 3
PKB alpha 97 13
PKB beta 90 18
SGK1 112 7
S6K1 95 0
PKA 119 2
ROCK 2 96 1
PRK2 101 9
PKC alpha 113 22
PKC gamma 110 9
PKC zeta 112 13
PKD1 96 6
STK33 83 4
MSK1 105 2
MNK1 103 3
MNK2 51 20
MAPKAP-K2 9 3
MAPKAP-K3 62 19
PRAK 67 11
CAMKK beta 87 23
CAMK1 97 12
SmMLCK 112 3
PHK 91 5
DAPK1 62 0
CHK1 109 10
CHK2 51 2
GSK3 beta 99 1
CDK2-Cyclin A 93 12
CDK9-Cyclin T1 96 4
PLK1 114 8
Aurora A 102 14
Aurora B 99 7
TLK1 107 3
LKB1 103 8
AMPK 38 1
AMPK (hum) 21 0
MARK1 107 2
MARK2 113 3
MARK3 115 0
MARK4 87 3
BRSK1 55 1
BRSK2 32 6
MELK 102 20
NUAK1 102 5
SIK2 86 7
SIK3 99 15
TSSK1 85 8
CK1 gamma 2 112 2
CK1 delta 96 5
CK2 97 4
TTBK1 104 14
TTBK2 122 18
DYRK1A 31 3
DYRK2 105 6
DYRK3 84 23
NEK2a 99 17
NEK6 96 1
IKK beta 109 0
IKK epsilon 95 12
TBK1 87 5
PIM1 58 1
PIM2 103 11
PIM3 18 3
SRPK1 63 0
EF2K 97 10
EIF2AK3 101 2
HIPK1 104 1
HIPK2 113 1
HIPK3 108 6
CLK2 43 2
PAK2 103 11
PAK4 88 4
PAK5 101 10
PAK6 106 8
MST2 135 34
MST3 109 4
MST4 101 1
GCK 89 1
MAP4K3 72 12
MAP4K5 108 15
MINK1 97 9
MEKK1 109 0
MLK1 95 13
MLK3 102 7
TESK1 111 7
TAO1 98 4
ASK1 80 5
TAK1 109 9
IRAK1 77 11
IRAK4 62 2
RIPK2 94 24
OSR1 112 2
TTK 101 0
MPSK1 118 3
WNK1 108 0
ULK1 89 14
ULK2 121 50
Src 116 5
Lck 95 8
CSK 111 21
YES1 89 1
ABL 113 6
BTK 118 11
JAK2 102 6
SYK 98 25
ZAP70 100 13
TIE2 86 1
BRK 94 9
EPH-A2 95 6
EPH-A4 103 9
EPH-B1 106 1
EPH-B2 110 15
EPH-B3 88 18
EPH-B4 106 9
FGF-R1 91 11
HER4 105 10
IGF-1R 108 6
IR 125 27
IRR 79 10
TrkA 100 0
DDR2 101 8
VEGFR1 118 35
PDGFRA 108 12
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 101 12
MKK2 113 7
MKK6 95 8
ERK1 111 7
ERK2 102 9
JNK1 96 10
JNK2 123 6
JNK3 120 8
p38 alpha MAPK 94 2
p38 beta MAPK 118 8
p38 gamma MAPK 108 1
p38 delta MAPK 108 6
ERK8 96 3
RSK1 106 1
RSK2 104 18
PDK1 104 13
PKB alpha 109 11
PKB beta 100 24
SGK1 116 19
S6K1 99 3
PKA 109 7
ROCK 2 112 6
PRK2 108 12
PKC alpha 101 8
PKC gamma 118 7
PKC zeta 115 6
PKD1 96 6
STK33 105 1
MSK1 120 3
MNK1 105 6
MNK2 111 4
MAPKAP-K2 24 6
MAPKAP-K3 114 5
PRAK 126 20
CAMKK beta 107 0
CAMK1 96 3
SmMLCK 118 4
PHK 110 12
DAPK1 103 10
CHK1 139 34
CHK2 112 16
GSK3 beta 126 2
CDK2-Cyclin A 111 1
CDK9-Cyclin T1 109 3
PLK1 102 7
Aurora A 126 20
Aurora B 109 2
TLK1 113 1
LKB1 118 6
AMPK 93 5
AMPK (hum) 68 1
MARK1 116 8
MARK2 116 2
MARK3 113 3
MARK4 107 8
BRSK1 86 7
BRSK2 77 13
MELK 123 3
NUAK1 112 20
SIK2 99 6
SIK3 98 13
TSSK1 97 6
CK1 gamma 2 123 4
CK1 delta 96 12
CK2 100 5
TTBK1 103 17
TTBK2 122 14
DYRK1A 80 4
DYRK2 101 3
DYRK3 111 0
NEK2a 108 17
NEK6 109 11
IKK beta 115 0
IKK epsilon 98 6
TBK1 110 9
PIM1 93 9
PIM2 103 15
PIM3 55 3
SRPK1 89 2
EF2K 106 1
EIF2AK3 114 10
HIPK1 111 1
HIPK2 123 29
HIPK3 112 4
CLK2 86 6
PAK2 102 19
PAK4 103 7
PAK5 108 6
PAK6 117 1
MST2 131 16
MST3 118 26
MST4 99 23
GCK 109 11
MAP4K3 98 3
MAP4K5 111 18
MINK1 98 20
MEKK1 102 16
MLK1 99 4
MLK3 114 1
TESK1 112 9
TAO1 109 2
ASK1 106 18
TAK1 113 9
IRAK1 104 16
IRAK4 94 6
RIPK2 93 8
OSR1 113 13
TTK 117 8
MPSK1 117 13
WNK1 113 2
ULK1 115 3
ULK2 109 17
Src 110 6
Lck 108 20
CSK 117 22
YES1 112 3
ABL 120 3
BTK 120 11
JAK2 101 4
SYK 94 6
ZAP70 93 9
TIE2 105 14
BRK 121 18
EPH-A2 90 3
EPH-A4 99 12
EPH-B1 113 2
EPH-B2 99 8
EPH-B3 98 12
EPH-B4 110 16
FGF-R1 95 3
HER4 92 1
IGF-1R 101 10
IR 123 17
IRR 99 6
TrkA 121 22
DDR2 105 1
VEGFR1 112 20
PDGFRA 104 3

Do you need any help? Please get in touch and we’ll be happy to lend a hand.