Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
HG-10-102-01 LRRK2 Choi H.G. (2012) ACS Med. Chem. Lett. Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 106 15
MKK2 91 17
MKK6 74 29
ERK1 95 16
ERK2 79 5
JNK1 89 8
JNK2 76 10
JNK3 60 1
p38 alpha MAPK 71 8
p38 beta MAPK 57 11
p38 gamma MAPK 88 21
p38 delta MAPK 87 0
ERK8 74 26
RSK1 87 10
RSK2 92 7
PDK1 102 11
PKB alpha 53 1
PKB beta 95 11
SGK1 94 3
S6K1 70 15
PKA 85 10
ROCK 2 87 7
PRK2 102 12
PKC alpha 66 6
PKC gamma 93 2
PKC zeta 99 10
PKD1 70 5
STK33 61 1
MSK1 104 8
MNK1 71 11
MNK2 20 9
MAPKAP-K2 88 4
MAPKAP-K3 120 81
PRAK 91 0
CAMKK beta 52 13
CAMK1 85 1
SmMLCK 83 1
PHK 68 11
DAPK1 61 13
CHK1 65 29
CHK2 52 2
GSK3 beta 100 1
CDK2-Cyclin A 82 2
CDK9-Cyclin T1 89 7
PLK1 97 23
Aurora A 56 4
Aurora B 83 1
TLK1 61 7
LKB1 92 1
AMPK 89 5
AMPK (hum) 91 7
MARK1 91 9
MARK2 85 7
MARK3 91 1
MARK4 82 7
BRSK1 59 18
BRSK2 78 11
MELK 88 21
NUAK1 43 1
SIK2 49 11
SIK3 93 6
TSSK1 51 3
CK1 gamma 2 96 10
CK1 delta 44 7
CK2 50 8
TTBK1 88 8
TTBK2 115 11
DYRK1A 79 12
DYRK2 44 7
DYRK3 84 1
NEK2a 63 1
NEK6 73 25
IKK beta 82 2
IKK epsilon 77 31
TBK1 86 3
PIM1 96 8
PIM2 94 13
PIM3 77 0
SRPK1 96 1
EF2K 83 3
EIF2AK3 99 19
HIPK1 77 10
HIPK2 77 23
HIPK3 85 0
CLK2 91 1
PAK2 97 4
PAK4 87 1
PAK5 88 3
PAK6 90 8
MST2 85 17
MST3 83 9
MST4 101 1
GCK 108 10
MAP4K3 94 11
MAP4K5 83 7
MINK1 86 4
MEKK1 93 2
MLK1 38 3
MLK3 75 10
TESK1 90 0
TAO1 81 22
ASK1 70 3
TAK1 74 16
IRAK1 84 21
IRAK4 90 6
RIPK2 79 6
OSR1 108 1
TTK 71 0
MPSK1 100 2
WNK1 62 20
ULK1 62 10
ULK2 97 9
Src 84 6
Lck 92 4
CSK 97 1
YES1 80 3
ABL 84 7
BTK 83 8
JAK2 83 8
SYK 68 17
ZAP70 97 4
TIE2 79 3
BRK 56 2
EPH-A2 93 9
EPH-A4 100 4
EPH-B1 115 1
EPH-B2 105 7
EPH-B3 67 2
EPH-B4 94 12
FGF-R1 89 6
HER4 89 4
IGF-1R 100 3
IR 86 4
IRR 126 5
TrkA 80 14
DDR2 103 16
VEGFR1 65 25
PDGFRA 79 0
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 93 7
MKK2 86 10
MKK6 65 7
ERK1 104 22
ERK2 69 11
JNK1 37 2
JNK2 46 3
JNK3 29 10
p38 alpha MAPK 93 10
p38 beta MAPK 93 6
p38 gamma MAPK 94 11
p38 delta MAPK 86 3
ERK8 82 5
RSK1 54 2
RSK2 65 10
PDK1 89 8
PKB alpha 85 1
PKB beta 64 8
SGK1 91 1
S6K1 67 15
PKA 94 8
ROCK 2 71 2
PRK2 92 10
PKC alpha 87 9
PKC gamma 108 6
PKC zeta 101 9
PKD1 25 4
STK33 28 1
MSK1 84 11
MNK1 44 6
MNK2 7 2
MAPKAP-K2 102 2
MAPKAP-K3 81 2
PRAK 44 1
CAMKK beta 31 3
CAMK1 66 3
SmMLCK 55 3
PHK 23 4
DAPK1 23 5
CHK1 45 4
CHK2 96 15
GSK3 beta 98 6
CDK2-Cyclin A 65 4
CDK9-Cyclin T1 83 3
PLK1 105 4
Aurora A 45 9
Aurora B 42 4
TLK1 100 9
LKB1 90 8
AMPK 80 1
AMPK (hum) 71 6
MARK1 84 7
MARK2 90 6
MARK3 78 2
MARK4 72 6
BRSK1 78 0
BRSK2 64 5
MELK 98 3
NUAK1 20 6
SIK2 47 0
SIK3 82 3
TSSK1 19 1
CK1 gamma 2 93 2
CK1 delta 89 9
CK2 88 1
TTBK1 91 4
TTBK2 97 12
DYRK1A 80 2
DYRK2 21 6
DYRK3 76 3
NEK2a 90 13
NEK6 69 19
IKK beta 80 7
IKK epsilon 75 2
TBK1 42 1
PIM1 99 0
PIM2 97 13
PIM3 72 4
SRPK1 94 22
EF2K 86 9
EIF2AK3 97 2
HIPK1 94 7
HIPK2 88 6
HIPK3 80 5
CLK2 76 5
PAK2 105 4
PAK4 84 8
PAK5 80 0
PAK6 98 9
MST2 73 10
MST3 80 5
MST4 106 9
GCK 79 11
MAP4K3 70 9
MAP4K5 82 7
MINK1 96 14
MEKK1 98 7
MLK1 18 0
MLK3 43 9
TESK1 83 15
TAO1 93 4
ASK1 54 3
TAK1 25 8
IRAK1 83 11
IRAK4 86 3
RIPK2 80 2
OSR1 82 10
TTK 57 5
MPSK1 97 7
WNK1 99 6
ULK1 85 2
ULK2 84 6
Src 79 0
Lck 95 5
CSK 103 11
YES1 90 5
ABL 86 9
BTK 88 2
JAK2 80 18
SYK 85 9
ZAP70 81 7
TIE2 90 0
BRK 39 1
EPH-A2 97 4
EPH-A4 94 7
EPH-B1 86 5
EPH-B2 103 8
EPH-B3 101 17
EPH-B4 113 7
FGF-R1 86 10
HER4 94 2
IGF-1R 51 7
IR 50 7
IRR 97 9
TrkA 87 1
DDR2 90 16
VEGFR1 35 2
PDGFRA 56 1

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