Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GSK2578215A C24H18FN3O2 399.42 LRRK2 Reith A. (2012) Bioorg. Med. Chem. Lett. WO2011038572 Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
SmMLCK 23 1
RIPK2 56 9
NUAK1 58 11
NEK6 65 13
STK33 66 4
SRPK1 69 17
PHK 75 7
PKD1 76 8
MINK1 76 17
CK1 gamma 2 77 1
PRK2 79 7
RSK2 81 0
HIPK1 81 28
RSK1 82 7
CK1 delta 82 3
MAPKAP-K3 82 0
AMPK 83 1
VEGFR1 83 11
HER4 84 9
MKK2 84 23
PKC gamma 84 11
MST3 84 32
PKB beta 85 7
HIPK3 85 9
DYRK3 85 16
ROCK 2 85 4
Aurora B 86 5
ABL 86 14
BTK 86 4
CLK2 86 3
JNK2 86 7
EPH-A4 86 3
PAK2 87 27
MNK1 88 14
MARK1 88 8
CAMK1 88 11
TBK1 88 9
GCK 89 3
Lck 90 33
PLK1 90 2
MEKK1 90 4
TrkA 90 9
CHK2 90 2
PDK1 91 10
JAK2 91 1
MKK6 91 4
IRAK1 91 8
IRAK4 91 9
TSSK1 92 7
MLK1 92 14
TAO1 92 6
ASK1 92 23
DYRK2 92 1
ZAP70 92 11
MARK4 92 0
MST2 92 11
FGF-R1 93 8
EF2K 93 10
TLK1 93 3
CK2 93 2
JNK1 93 0
MELK 93 17
Aurora A 94 9
PAK4 94 7
JNK3 94 3
PKC alpha 94 5
MST4 94 8
p38 delta MAPK 95 3
MARK2 95 10
PKA 95 10
DAPK1 95 9
OSR1 95 6
EPH-B1 95 28
MAPKAP-K2 96 9
TESK1 96 8
IRR 96 3
PKB alpha 96 7
SGK1 96 3
CAMKK beta 96 9
S6K1 96 4
TTK 96 5
PKC zeta 96 3
GSK3 beta 96 3
EIF2AK3 97 9
ERK1 97 0
NEK2a 97 16
BRSK1 97 5
BRSK2 97 11
p38 gamma MAPK 98 7
MNK2 98 7
MKK1 98 5
TTBK1 98 5
MARK3 98 1
PAK6 98 2
p38 beta MAPK 98 1
ERK8 99 9
MLK3 99 3
PIM2 100 12
PIM3 100 6
DDR2 100 15
PAK5 100 3
SIK3 101 0
TAK1 101 1
BRK 101 13
IKK beta 101 13
IR 102 8
CHK1 102 13
IKK epsilon 102 1
p38 alpha MAPK 102 6
MPSK1 102 3
CDK9-Cyclin T1 103 17
DYRK1A 104 21
EPH-A2 104 4
LKB1 105 1
WNK1 106 8
HIPK2 107 8
EPH-B4 108 13
PIM1 109 7
SIK2 111 3
EPH-B3 113 4
CSK 114 22
PRAK 114 14
ERK2 115 1
EPH-B2 115 21
CDK2-Cyclin A 117 2
IGF-1R 117 13
MSK1 120 3
SYK 125 7
TIE2 133 9
YES1 140 37
Src 160 3
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
NUAK1 31 2
SmMLCK 32 1
RIPK2 59 8
SRPK1 61 5
STK33 64 5
RSK1 69 4
MLK1 69 10
CAMKK beta 71 13
IRR 76 2
HIPK1 77 2
MKK1 77 6
PHK 78 1
TrkA 80 4
PKD1 80 15
CK1 gamma 2 81 2
TTBK1 81 5
ROCK 2 82 10
GCK 82 6
RSK2 83 4
MAPKAP-K3 84 21
VEGFR1 84 2
MKK2 85 11
MARK1 85 1
SIK3 85 1
Aurora B 86 4
CLK2 86 3
BTK 87 7
MINK1 87 4
MNK1 88 8
TESK1 88 3
SGK1 89 10
MARK2 89 16
EPH-B1 89 5
CHK2 89 8
AMPK 90 9
DYRK2 90 12
CAMK1 90 8
IRAK4 90 1
NEK6 90 0
OSR1 90 8
CHK1 90 8
JNK1 91 1
BRSK2 91 9
DYRK1A 92 5
MKK6 92 6
EPH-A2 92 13
IKK beta 92 11
MNK2 93 13
HIPK3 93 10
BRSK1 93 1
EPH-A4 93 3
PKC alpha 93 4
TTK 93 12
PKC gamma 93 13
Src 93 10
MEKK1 93 1
PKB alpha 94 11
TAO1 94 1
MST4 94 11
PKB beta 95 2
PAK5 95 3
JNK3 95 13
HER4 95 9
PKC zeta 96 17
ABL 97 4
IR 97 8
PDK1 97 1
LKB1 97 5
IRAK1 97 9
PAK4 97 1
TBK1 97 12
MSK1 97 2
PLK1 97 4
EF2K 98 5
EIF2AK3 98 0
CK2 98 5
PKA 98 11
PRK2 98 1
p38 gamma MAPK 99 11
ERK8 99 10
Aurora A 100 5
MAPKAP-K2 100 5
TLK1 100 9
ASK1 100 15
NEK2a 100 9
MARK4 100 2
CDK9-Cyclin T1 100 5
S6K1 101 11
DYRK3 101 13
MARK3 101 7
DAPK1 101 5
p38 alpha MAPK 101 12
MST3 101 14
p38 delta MAPK 101 0
JAK2 102 1
MELK 102 1
PIM1 102 4
PIM2 102 3
ZAP70 103 3
BRK 103 0
MST2 103 28
PIM3 103 11
TSSK1 103 19
ERK2 104 23
PAK6 104 25
p38 beta MAPK 104 25
WNK1 104 11
CSK 104 4
ERK1 105 2
MPSK1 105 2
MLK3 106 3
HIPK2 106 14
IKK epsilon 106 20
CK1 delta 107 4
DDR2 107 2
JNK2 107 8
TAK1 108 13
SIK2 108 6
PRAK 109 4
FGF-R1 110 20
CDK2-Cyclin A 113 12
Lck 113 16
SYK 115 13
PAK2 116 15
EPH-B4 118 2
TIE2 119 19
GSK3 beta 119 13
YES1 120 2
EPH-B3 121 18
IGF-1R 123 8
EPH-B2 123 1

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