Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GSK2578215A C24H18FN3O2 399.42 LRRK2 Reith A. (2012) Bioorg. Med. Chem. Lett. WO2011038572 Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 77 6
MKK2 85 11
MKK6 92 6
ERK1 105 2
ERK2 104 23
JNK1 91 1
JNK2 107 8
JNK3 95 13
p38 alpha MAPK 101 12
p38 beta MAPK 104 25
p38 gamma MAPK 99 11
p38 delta MAPK 101 0
ERK8 99 10
RSK1 69 4
RSK2 83 4
PDK1 97 1
PKB alpha 94 11
PKB beta 95 2
SGK1 89 10
S6K1 101 11
PKA 98 11
ROCK 2 82 10
PRK2 98 1
PKC alpha 93 4
PKC gamma 93 13
PKC zeta 96 17
PKD1 80 15
STK33 64 5
MSK1 97 2
MNK1 88 8
MNK2 93 13
MAPKAP-K2 100 5
MAPKAP-K3 84 21
PRAK 109 4
CAMKK beta 71 13
CAMK1 90 8
SmMLCK 32 1
PHK 78 1
DAPK1 101 5
CHK1 90 8
CHK2 89 8
GSK3 beta 119 13
CDK2-Cyclin A 113 12
CDK9-Cyclin T1 100 5
PLK1 97 4
Aurora A 100 5
Aurora B 86 4
TLK1 100 9
LKB1 97 5
AMPK 90 9
MARK1 85 1
MARK2 89 16
MARK3 101 7
MARK4 100 2
BRSK1 93 1
BRSK2 91 9
MELK 102 1
NUAK1 31 2
SIK2 108 6
SIK3 85 1
TSSK1 103 19
CK1 gamma 2 81 2
CK1 delta 107 4
CK2 98 5
TTBK1 81 5
DYRK1A 92 5
DYRK2 90 12
DYRK3 101 13
NEK2a 100 9
NEK6 90 0
IKK beta 92 11
IKK epsilon 106 20
TBK1 97 12
PIM1 102 4
PIM2 102 3
PIM3 103 11
SRPK1 61 5
EF2K 98 5
EIF2AK3 98 0
HIPK1 77 2
HIPK2 106 14
HIPK3 93 10
CLK2 86 3
PAK2 116 15
PAK4 97 1
PAK5 95 3
PAK6 104 25
MST2 103 28
MST3 101 14
MST4 94 11
GCK 82 6
MINK1 87 4
MEKK1 93 1
MLK1 69 10
MLK3 106 3
TESK1 88 3
TAO1 94 1
ASK1 100 15
TAK1 108 13
IRAK1 97 9
IRAK4 90 1
RIPK2 59 8
OSR1 90 8
TTK 93 12
MPSK1 105 2
WNK1 104 11
Src 93 10
Lck 113 16
CSK 104 4
YES1 120 2
ABL 97 4
BTK 87 7
JAK2 102 1
SYK 115 13
ZAP70 103 3
TIE2 119 19
BRK 103 0
EPH-A2 92 13
EPH-A4 93 3
EPH-B1 89 5
EPH-B2 123 1
EPH-B3 121 18
EPH-B4 118 2
FGF-R1 110 20
HER4 95 9
IGF-1R 123 8
IR 97 8
IRR 76 2
TrkA 80 4
DDR2 107 2
VEGFR1 84 2
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 98 5
MKK2 84 23
MKK6 91 4
ERK1 97 0
ERK2 115 1
JNK1 93 0
JNK2 86 7
JNK3 94 3
p38 alpha MAPK 102 6
p38 beta MAPK 98 1
p38 gamma MAPK 98 7
p38 delta MAPK 95 3
ERK8 99 9
RSK1 82 7
RSK2 81 0
PDK1 91 10
PKB alpha 96 7
PKB beta 85 7
SGK1 96 3
S6K1 96 4
PKA 95 10
ROCK 2 85 4
PRK2 79 7
PKC alpha 94 5
PKC gamma 84 11
PKC zeta 96 3
PKD1 76 8
STK33 66 4
MSK1 120 3
MNK1 88 14
MNK2 98 7
MAPKAP-K2 96 9
MAPKAP-K3 82 0
PRAK 114 14
CAMKK beta 96 9
CAMK1 88 11
SmMLCK 23 1
PHK 75 7
DAPK1 95 9
CHK1 102 13
CHK2 90 2
GSK3 beta 96 3
CDK2-Cyclin A 117 2
CDK9-Cyclin T1 103 17
PLK1 90 2
Aurora A 94 9
Aurora B 86 5
TLK1 93 3
LKB1 105 1
AMPK 83 1
MARK1 88 8
MARK2 95 10
MARK3 98 1
MARK4 92 0
BRSK1 97 5
BRSK2 97 11
MELK 93 17
NUAK1 58 11
SIK2 111 3
SIK3 101 0
TSSK1 92 7
CK1 gamma 2 77 1
CK1 delta 82 3
CK2 93 2
TTBK1 98 5
DYRK1A 104 21
DYRK2 92 1
DYRK3 85 16
NEK2a 97 16
NEK6 65 13
IKK beta 101 13
IKK epsilon 102 1
TBK1 88 9
PIM1 109 7
PIM2 100 12
PIM3 100 6
SRPK1 69 17
EF2K 93 10
EIF2AK3 97 9
HIPK1 81 28
HIPK2 107 8
HIPK3 85 9
CLK2 86 3
PAK2 87 27
PAK4 94 7
PAK5 100 3
PAK6 98 2
MST2 92 11
MST3 84 32
MST4 94 8
GCK 89 3
MINK1 76 17
MEKK1 90 4
MLK1 92 14
MLK3 99 3
TESK1 96 8
TAO1 92 6
ASK1 92 23
TAK1 101 1
IRAK1 91 8
IRAK4 91 9
RIPK2 56 9
OSR1 95 6
TTK 96 5
MPSK1 102 3
WNK1 106 8
Src 160 3
Lck 90 33
CSK 114 22
YES1 140 37
ABL 86 14
BTK 86 4
JAK2 91 1
SYK 125 7
ZAP70 92 11
TIE2 133 9
BRK 101 13
EPH-A2 104 4
EPH-A4 86 3
EPH-B1 95 28
EPH-B2 115 21
EPH-B3 113 4
EPH-B4 108 13
FGF-R1 93 8
HER4 84 9
IGF-1R 117 13
IR 102 8
IRR 96 3
TrkA 90 9
DDR2 100 15
VEGFR1 83 11

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