Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
TAE684 C30H40ClN7O3S 614.22 NPM-ALK Zhang J. (2012) Bioorg. Med. Chem. Lett. 22 1864–1869 Galkin A.V. (2007) Proc. Natl. Acad. Sci. USA 104 (1) 270-275 Axon Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 91 10
MKK2 69 1
MKK6 90 16
ERK1 86 16
ERK2 78 17
JNK1 87 18
JNK2 80 11
JNK3 81 2
p38 alpha MAPK 88 2
p38 beta MAPK 100 14
p38 gamma MAPK 102 10
p38 delta MAPK 94 19
ERK8 47 4
RSK1 14 3
RSK2 24 2
PDK1 101 15
PKB alpha 102 8
PKB beta 82 16
SGK1 89 11
S6K1 99 16
PKA 90 17
ROCK 2 85 17
PRK2 51 18
PKC alpha 109 6
PKC gamma 100 9
PKC zeta 118 7
PKD1 37 15
STK33 16 3
MSK1 80 13
MNK1 106 9
MNK2 101 33
MAPKAP-K2 115 3
MAPKAP-K3 94 19
PRAK 101 1
CAMKK beta 9 1
CAMK1 94 13
SmMLCK 78 7
PHK 6 1
DAPK1 98 7
CHK1 37 12
CHK2 3 0
GSK3 beta 104 13
CDK2-Cyclin A 68 6
PLK1 84 6
Aurora A 15 5
Aurora B 114 23
TLK1 100 2
LKB1 94 16
AMPK 27 3
MARK1 36 4
MARK2 27 0
MARK3 34 9
MARK4 37 4
BRSK1 31 11
BRSK2 28 4
MELK 71 2
NUAK1 10 6
TSSK1 10 1
CK1 delta 102 1
CK2 87 14
TTBK1 88 15
DYRK1A 100 9
DYRK2 105 24
DYRK3 97 4
NEK2a 81 5
NEK6 83 12
IKK beta 98 11
IKK epsilon 89 7
TBK1 93 27
PIM1 98 19
PIM2 91 14
PIM3 106 17
SRPK1 86 4
EF2K 96 20
EIF2AK3 101 3
HIPK1 105 2
HIPK2 86 10
HIPK3 81 6
CLK2 14 2
PAK2 86 3
PAK4 75 6
PAK5 66 2
PAK6 103 11
MST2 56 16
MST4 92 26
GCK 45 11
MINK1 72 7
MEKK1 109 13
MLK1 24 3
MLK3 64 12
TESK1 120 2
TAO1 61 1
ASK1 97 10
TAK1 62 17
IRAK1 41 1
IRAK4 43 3
RIPK2 94 21
OSR1 61 23
TTK 73 18
MPSK1 102 6
Src 44 10
Lck 24 8
CSK 77 8
YES1 13 5
ABL 97 1
BTK 53 7
JAK2 21 3
SYK 85 26
ZAP70 113 17
TIE2 18 2
BRK 21 8
EPH-A2 70 7
EPH-A4 52 8
EPH-B1 50 13
EPH-B2 83 4
EPH-B3 80 34
EPH-B4 73 2
FGF-R1 10 0
HER4 36 9
IGF-1R 4 1
IR 17 2
IRR 98 2
TrkA 41 7
VEGFR1 22 8
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 30 3
MKK2 30 8
MKK6 75 16
ERK1 53 0
ERK2 40 2
JNK1 28 4
JNK2 62 38
JNK3 38 3
p38 alpha MAPK 79 9
p38 beta MAPK 92 2
p38 gamma MAPK 98 17
p38 delta MAPK 87 5
ERK8 26 5
RSK1 8 2
RSK2 15 5
PDK1 87 16
PKB alpha 109 2
PKB beta 76 3
SGK1 88 1
S6K1 68 15
PKA 64 13
ROCK 2 40 13
PRK2 18 5
PKC alpha 122 31
PKC gamma 101 12
PKC zeta 99 1
PKD1 12 1
STK33 16 1
MSK1 45 2
MNK1 97 18
MNK2 60 2
MAPKAP-K2 118 13
MAPKAP-K3 100 2
PRAK 110 21
CAMKK beta 5 1
CAMK1 37 2
SmMLCK 43 8
PHK 2 0
DAPK1 79 1
CHK1 12 1
CHK2 3 0
GSK3 beta 92 9
CDK2-Cyclin A 38 12
PLK1 38 3
Aurora A 2 0
Aurora B 76 7
TLK1 114 10
LKB1 77 0
AMPK 34 0
MARK1 13 2
MARK2 6 1
MARK3 7 3
MARK4 19 3
BRSK1 8 2
BRSK2 11 1
MELK 21 6
NUAK1 3 0
TSSK1 8 2
CK1 delta 102 3
CK2 75 2
TTBK1 101 28
DYRK1A 77 6
DYRK2 106 8
DYRK3 94 15
NEK2a 43 2
NEK6 80 6
IKK beta 107 14
IKK epsilon 86 14
TBK1 71 2
PIM1 101 9
PIM2 107 6
PIM3 104 22
SRPK1 46 9
EF2K 94 3
EIF2AK3 95 4
HIPK1 97 8
HIPK2 89 20
HIPK3 83 4
CLK2 3 0
PAK2 57 10
PAK4 44 4
PAK5 35 6
PAK6 85 1
MST2 23 4
MST4 55 3
GCK 17 0
MINK1 13 1
MEKK1 104 8
MLK1 8 2
MLK3 27 2
TESK1 85 19
TAO1 23 12
ASK1 78 3
TAK1 15 2
IRAK1 12 4
IRAK4 16 4
RIPK2 59 0
OSR1 16 2
TTK 47 0
MPSK1 96 13
Src 20 17
Lck 7 1
CSK 33 3
YES1 3 0
ABL 39 2
BTK 38 4
JAK2 8 2
SYK 28 1
ZAP70 129 52
TIE2 5 1
BRK 5 0
EPH-A2 27 1
EPH-A4 13 3
EPH-B1 7 2
EPH-B2 23 6
EPH-B3 26 3
EPH-B4 23 7
FGF-R1 2 0
HER4 7 1
IGF-1R 3 0
IR 22 8
IRR 66 0
TrkA 16 5
VEGFR1 12 1

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