Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
IRAK-4 kinase inhibitor b C22H24N4O6 440.45 IRAK4 Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 94 7
MKK2 86 6
MKK6 108 4
ERK1 91 11
ERK2 103 12
JNK1 97 13
JNK2 96 11
JNK3 97 9
p38 alpha MAPK 83 10
p38 beta MAPK 93 13
p38 gamma MAPK 98 11
p38 delta MAPK 83 15
ERK8 83 14
RSK1 84 12
RSK2 92 14
PDK1 100 9
PKB alpha 98 7
PKB beta 82 8
SGK1 95 1
S6K1 98 2
PKA 93 9
ROCK 2 95 15
PRK2 103 23
PKC alpha 108 9
PKC gamma 99 1
PKC zeta 99 14
PKD1 88 6
STK33 93 28
MSK1 98 1
MNK1 107 10
MNK2 96 2
MAPKAP-K2 101 1
MAPKAP-K3 93 21
PRAK 103 12
CAMKK beta 88 13
CAMK1 120 10
SmMLCK 88 14
PHK 95 6
DAPK1 90 11
CHK1 84 4
CHK2 96 17
GSK3 beta 91 13
CDK2-Cyclin A 93 2
PLK1 95 9
Aurora A 96 4
Aurora B 71 9
TLK1 104 12
LKB1 92 12
AMPK 94 2
MARK1 95 13
MARK2 106 16
MARK3 92 11
MARK4 85 9
BRSK1 97 24
BRSK2 94 5
MELK 99 21
NUAK1 90 12
TSSK1 102 20
CK1 delta 79 5
CK2 81 0
TTBK1 93 1
DYRK1A 94 3
DYRK2 102 13
DYRK3 98 2
NEK2a 94 6
NEK6 82 10
IKK beta 93 9
IKK epsilon 90 2
TBK1 89 12
PIM1 96 8
PIM2 89 5
PIM3 95 2
SRPK1 93 3
EF2K 89 21
EIF2AK3 87 10
HIPK1 106 15
HIPK2 88 5
HIPK3 83 12
CLK2 70 16
PAK2 93 13
PAK4 81 14
PAK5 99 13
PAK6 101 16
MST2 103 11
MST4 91 4
GCK 91 7
MINK1 88 9
MEKK1 106 27
MLK1 86 11
MLK3 97 8
TESK1 101 7
TAO1 102 11
ASK1 104 3
TAK1 76 27
IRAK1 18 4
IRAK4 34 4
RIPK2 83 24
OSR1 101 2
TTK 89 18
MPSK1 90 1
Src 111 15
Lck 85 18
CSK 74 6
YES1 106 4
ABL 105 20
BTK 87 1
JAK2 89 2
SYK 87 12
ZAP70 99 11
TIE2 83 4
BRK 96 6
EPH-A2 94 14
EPH-A4 94 8
EPH-B1 107 29
EPH-B2 104 16
EPH-B3 98 11
EPH-B4 85 14
FGF-R1 106 4
HER4 89 20
IGF-1R 96 24
IR 93 22
IRR 102 19
TrkA 73 12
VEGFR1 90 1
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 82 1
MKK2 59 5
MKK6 124 17
ERK1 83 2
ERK2 93 1
JNK1 100 24
JNK2 93 5
JNK3 95 13
p38 alpha MAPK 80 7
p38 beta MAPK 93 4
p38 gamma MAPK 88 14
p38 delta MAPK 87 9
ERK8 63 0
RSK1 83 4
RSK2 89 18
PDK1 99 3
PKB alpha 93 3
PKB beta 74 12
SGK1 81 17
S6K1 94 2
PKA 93 2
ROCK 2 96 5
PRK2 91 7
PKC alpha 101 1
PKC gamma 94 5
PKC zeta 108 2
PKD1 70 4
STK33 77 6
MSK1 93 7
MNK1 104 0
MNK2 96 6
MAPKAP-K2 103 4
MAPKAP-K3 84 2
PRAK 93 7
CAMKK beta 61 1
CAMK1 122 15
SmMLCK 89 13
PHK 65 9
DAPK1 89 3
CHK1 89 2
CHK2 86 1
GSK3 beta 83 4
CDK2-Cyclin A 83 6
PLK1 99 5
Aurora A 86 3
Aurora B 77 2
TLK1 95 7
LKB1 82 2
AMPK 92 8
MARK1 82 1
MARK2 84 0
MARK3 85 7
MARK4 89 2
BRSK1 107 6
BRSK2 100 8
MELK 89 4
NUAK1 78 2
TSSK1 89 8
CK1 delta 40 1
CK2 74 7
TTBK1 86 7
DYRK1A 64 3
DYRK2 95 1
DYRK3 71 1
NEK2a 86 3
NEK6 71 0
IKK beta 87 3
IKK epsilon 85 7
TBK1 92 2
PIM1 87 3
PIM2 88 2
PIM3 90 5
SRPK1 58 6
EF2K 87 3
EIF2AK3 101 5
HIPK1 84 10
HIPK2 76 12
HIPK3 84 10
CLK2 16 3
PAK2 89 6
PAK4 77 5
PAK5 76 1
PAK6 94 9
MST2 95 2
MST4 94 0
GCK 61 3
MINK1 46 1
MEKK1 96 4
MLK1 66 2
MLK3 84 12
TESK1 92 6
TAO1 100 10
ASK1 90 5
TAK1 34 5
IRAK1 8 3
IRAK4 8 2
RIPK2 94 2
OSR1 95 1
TTK 66 1
MPSK1 91 8
Src 92 14
Lck 85 1
CSK 88 0
YES1 97 2
ABL 101 10
BTK 103 6
JAK2 85 2
SYK 101 9
ZAP70 98 23
TIE2 93 15
BRK 102 8
EPH-A2 86 4
EPH-A4 96 4
EPH-B1 99 15
EPH-B2 97 7
EPH-B3 88 4
EPH-B4 92 1
FGF-R1 105 2
HER4 96 1
IGF-1R 87 14
IR 97 6
IRR 61 3
TrkA 73 1
VEGFR1 66 22

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