Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Hypothemycin C19H22O8 378.37 cyclin D1 H. Sonoda (1999) Life Sci. 65 381 A. Zhao (1999) J. Antibiot. 52 1086 Sigma Download

Results as Barchart

View results as a bar chart
1µM
0.1µM
0.01µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
MKK1 1 1
TAK1 2 1
VEGFR1 3 0
MKK2 9 0
PKD1 11 1
ERK8 11 0
MKK6 20 15
PRAK 32 3
ERK2 36 3
MNK2 44 6
BRK 48 2
MNK1 55 3
EPH-A2 56 3
ERK1 57 3
IRAK4 57 2
TrkA 67 9
Lck 69 8
HIPK2 72 12
CDK2-Cyclin A 76 2
JNK1 80 3
YES1 81 21
BRSK1 82 9
EPH-B1 84 9
RSK1 85 4
SYK 85 2
RIPK2 85 6
MST4 86 1
Src 86 3
SIK2 88 10
PRK2 89 27
PKC gamma 89 0
MLK3 90 9
PIM1 92 5
ULK1 92 15
EPH-B3 92 6
CK1 delta 92 22
TESK1 92 12
PKC alpha 92 13
IKK epsilon 92 9
PDK1 93 9
TBK1 93 5
SIK3 94 7
AMPK 94 3
CAMKK beta 94 29
MARK4 94 23
CHK1 94 12
CSK 95 24
HIPK1 95 12
PAK2 95 13
MARK3 95 13
PAK6 95 13
SmMLCK 96 2
DAPK1 96 14
BRSK2 96 3
GCK 97 7
IR 97 4
p38 beta MAPK 98 3
NEK6 98 7
PIM3 99 6
TSSK1 99 7
MAPKAP-K3 99 9
PKB beta 99 21
ROCK 2 99 13
JNK2 99 3
SRPK1 100 4
TAO1 100 5
MARK2 100 4
PKA 100 18
MLK1 101 7
DYRK1A 101 11
MARK1 101 9
TTK 101 5
MINK1 102 16
MEKK1 102 13
HIPK3 102 4
DYRK2 102 24
MST2 102 3
MPSK1 102 4
ZAP70 103 10
PAK5 103 20
MSK1 104 8
LKB1 104 2
SGK1 104 17
PAK4 104 31
MELK 104 7
PKC zeta 105 5
NUAK1 105 16
HER4 105 3
ABL 105 5
NEK2a 105 4
p38 alpha MAPK 105 13
WNK1 106 3
S6K1 106 5
CHK2 106 20
Aurora B 107 1
PKB alpha 107 3
PHK 107 7
JNK3 107 5
EPH-A4 107 3
p38 delta MAPK 108 0
Aurora A 108 5
CK1 gamma 2 109 6
MAPKAP-K2 109 22
ASK1 109 4
BTK 109 2
JAK2 109 25
IRAK1 109 43
CDK9-Cyclin T1 111 3
TTBK1 112 35
CAMK1 112 6
IKK beta 112 10
GSK3 beta 113 48
STK33 113 5
IRR 113 11
p38 gamma MAPK 114 28
PLK1 114 2
CLK2 114 24
MST3 114 13
EPH-B2 115 0
EPH-B4 116 35
PIM2 117 29
ULK2 118 35
IGF-1R 119 44
TLK1 120 31
EIF2AK3 121 48
TIE2 122 11
DYRK3 124 6
RSK2 129 19
OSR1 129 30
FGF-R1 132 24
EF2K 133 26
CK2 133 7
DDR2 133 55
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
VEGFR1 5 2
MKK1 21 5
MKK2 21 1
MKK6 21 12
ERK8 27 0
PKD1 41 1
TAK1 48 5
MNK2 62 16
PRAK 72 17
PKC zeta 78 12
CDK2-Cyclin A 81 9
TTBK1 82 15
YES1 85 18
MPSK1 86 30
HIPK2 86 5
ERK2 87 17
PIM1 87 10
MNK1 87 5
PKC alpha 88 3
ULK1 88 1
PDK1 88 22
MST2 89 9
NEK6 90 12
BRSK1 90 9
TrkA 90 19
CHK2 91 12
Src 91 5
SGK1 91 15
RSK1 92 10
Aurora B 92 4
EIF2AK3 92 5
S6K1 92 9
CHK1 93 14
BRSK2 93 12
p38 beta MAPK 93 1
SIK3 93 7
Lck 93 1
ROCK 2 94 15
PAK2 94 6
PAK6 95 4
TTK 95 13
SRPK1 95 11
ULK2 96 2
CAMK1 96 13
ABL 97 4
IRAK1 97 7
JNK1 98 8
PHK 98 2
EPH-A2 98 5
PIM3 98 6
PKA 99 3
IRAK4 99 5
MARK4 99 3
OSR1 99 4
NUAK1 99 3
HIPK1 99 19
MAPKAP-K3 99 2
CAMKK beta 99 9
MARK1 99 2
PAK4 100 5
IKK beta 100 3
BRK 100 24
MELK 100 2
p38 delta MAPK 100 3
CK1 gamma 2 100 2
IGF-1R 100 14
HIPK3 100 0
CLK2 100 3
MARK2 100 1
ZAP70 101 7
TIE2 101 11
PRK2 101 23
JNK3 101 18
MEKK1 101 13
CK1 delta 101 3
MAPKAP-K2 101 4
TLK1 101 7
TAO1 101 2
JAK2 101 6
SmMLCK 102 4
MARK3 102 3
RIPK2 102 8
MLK3 102 0
ERK1 102 9
Aurora A 103 6
EF2K 103 4
PKB beta 103 7
ASK1 103 3
MST3 104 3
MSK1 104 10
HER4 104 14
IKK epsilon 105 4
p38 alpha MAPK 105 6
p38 gamma MAPK 105 18
GCK 105 3
STK33 105 1
CSK 105 9
AMPK 105 14
DYRK1A 105 4
DYRK2 105 6
JNK2 106 6
GSK3 beta 106 5
MST4 106 9
WNK1 107 1
SIK2 107 2
PLK1 107 7
TESK1 107 6
DAPK1 108 10
IRR 108 3
SYK 108 2
PKC gamma 109 4
DYRK3 109 3
EPH-B1 110 3
TSSK1 110 8
MINK1 111 8
TBK1 112 6
DDR2 113 10
PIM2 114 2
PAK5 115 2
BTK 115 11
EPH-B4 116 14
IR 116 1
CDK9-Cyclin T1 117 17
MLK1 117 4
EPH-B2 118 2
LKB1 120 19
CK2 121 5
EPH-A4 122 2
PKB alpha 124 2
RSK2 125 19
NEK2a 127 7
EPH-B3 130 12
FGF-R1 154 18
Screening Concentration: 0.01µM
Kinase % Activity Remainingsort descending Standard Deviation
MKK6 59 0
VEGFR1 65 15
MKK2 74 0
PRAK 74 11
Lck 79 6
ERK8 80 14
PAK4 81 9
DAPK1 82 18
JAK2 84 2
YES1 87 0
S6K1 87 11
PKC alpha 88 15
p38 beta MAPK 88 6
PDK1 89 5
TTBK1 89 4
JNK3 89 11
PKD1 89 13
MARK2 90 7
BRSK1 90 17
PIM1 90 6
Aurora B 90 5
DDR2 91 11
PKA 91 10
ROCK 2 91 5
CHK2 91 3
GSK3 beta 91 5
CDK2-Cyclin A 91 6
ULK1 91 2
EF2K 91 6
MNK2 91 2
MLK3 91 20
PAK6 92 1
MELK 92 2
PIM3 92 7
MAPKAP-K2 93 7
SGK1 93 2
PRK2 93 8
CHK1 93 15
NUAK1 93 5
PIM2 93 3
CLK2 94 2
MPSK1 94 5
WNK1 94 2
ULK2 94 3
TLK1 95 5
HIPK2 96 12
ABL 96 6
CAMK1 96 0
ERK2 96 9
MST4 96 9
Src 96 15
TrkA 97 0
IRAK1 97 4
NEK6 97 19
MST2 97 6
EPH-A2 97 3
PKC zeta 97 11
EPH-B1 97 5
CDK9-Cyclin T1 97 5
RSK1 97 22
CSK 97 25
DYRK1A 98 1
MARK3 98 5
PAK2 99 1
ZAP70 99 20
PHK 100 7
p38 gamma MAPK 100 1
MNK1 100 6
CK1 gamma 2 100 10
MKK1 101 3
MARK1 101 5
TAK1 101 5
BRK 101 12
TTK 101 4
p38 delta MAPK 101 6
CAMKK beta 102 10
PAK5 102 0
SIK3 102 4
PLK1 102 0
IGF-1R 103 14
NEK2a 103 11
MARK4 103 1
IKK beta 103 3
PKC gamma 103 17
HIPK3 104 1
IRR 104 2
JNK1 104 14
RIPK2 104 10
OSR1 104 3
MAPKAP-K3 105 19
PKB beta 105 2
AMPK 105 2
ASK1 105 12
BTK 105 9
JNK2 105 14
EIF2AK3 105 6
TAO1 106 3
MST3 106 10
SIK2 106 9
MINK1 106 7
Aurora A 106 5
SmMLCK 108 7
IKK epsilon 108 9
p38 alpha MAPK 108 18
MSK1 108 11
PKB alpha 109 2
DYRK2 109 4
EPH-A4 109 10
EPH-B4 109 1
TBK1 110 7
HIPK1 111 9
ERK1 111 5
SRPK1 111 19
IR 112 18
SYK 112 26
IRAK4 112 3
TSSK1 112 9
MEKK1 112 1
MLK1 112 12
DYRK3 113 6
STK33 113 9
BRSK2 114 11
GCK 114 7
CK1 delta 116 5
EPH-B3 118 19
FGF-R1 118 7
LKB1 119 10
TESK1 120 36
TIE2 122 14
CK2 123 1
EPH-B2 124 15
RSK2 129 16
HER4 132 24

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