Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Hypothemycin C19H22O8 378.37 cyclin D1 H. Sonoda (1999) Life Sci. 65 381 A. Zhao (1999) J. Antibiot. 52 1086 Sigma Download

Results as Barchart

View results as a bar chart
1µM
0.1µM
0.01µM

Results as Table

Screening Concentration: 0.01µM
Kinase % Activity Remaining Standard Deviation
MKK1 101 3
MKK2 74 0
MKK6 59 0
ERK1 111 5
ERK2 96 9
JNK1 104 14
JNK2 105 14
JNK3 89 11
p38 alpha MAPK 108 18
p38 beta MAPK 88 6
p38 gamma MAPK 100 1
p38 delta MAPK 101 6
ERK8 80 14
RSK1 97 22
RSK2 129 16
PDK1 89 5
PKB alpha 109 2
PKB beta 105 2
SGK1 93 2
S6K1 87 11
PKA 91 10
ROCK 2 91 5
PRK2 93 8
PKC alpha 88 15
PKC gamma 103 17
PKC zeta 97 11
PKD1 89 13
STK33 113 9
MSK1 108 11
MNK1 100 6
MNK2 91 2
MAPKAP-K2 93 7
MAPKAP-K3 105 19
PRAK 74 11
CAMKK beta 102 10
CAMK1 96 0
SmMLCK 108 7
PHK 100 7
DAPK1 82 18
CHK1 93 15
CHK2 91 3
GSK3 beta 91 5
CDK2-Cyclin A 91 6
CDK9-Cyclin T1 97 5
PLK1 102 0
Aurora A 106 5
Aurora B 90 5
TLK1 95 5
LKB1 119 10
AMPK 105 2
MARK1 101 5
MARK2 90 7
MARK3 98 5
MARK4 103 1
BRSK1 90 17
BRSK2 114 11
MELK 92 2
NUAK1 93 5
SIK2 106 9
SIK3 102 4
TSSK1 112 9
CK1 gamma 2 100 10
CK1 delta 116 5
CK2 123 1
TTBK1 89 4
DYRK1A 98 1
DYRK2 109 4
DYRK3 113 6
NEK2a 103 11
NEK6 97 19
IKK beta 103 3
IKK epsilon 108 9
TBK1 110 7
PIM1 90 6
PIM2 93 3
PIM3 92 7
SRPK1 111 19
EF2K 91 6
EIF2AK3 105 6
HIPK1 111 9
HIPK2 96 12
HIPK3 104 1
CLK2 94 2
PAK2 99 1
PAK4 81 9
PAK5 102 0
PAK6 92 1
MST2 97 6
MST3 106 10
MST4 96 9
GCK 114 7
MINK1 106 7
MEKK1 112 1
MLK1 112 12
MLK3 91 20
TESK1 120 36
TAO1 106 3
ASK1 105 12
TAK1 101 5
IRAK1 97 4
IRAK4 112 3
RIPK2 104 10
OSR1 104 3
TTK 101 4
MPSK1 94 5
WNK1 94 2
ULK1 91 2
ULK2 94 3
Src 96 15
Lck 79 6
CSK 97 25
YES1 87 0
ABL 96 6
BTK 105 9
JAK2 84 2
SYK 112 26
ZAP70 99 20
TIE2 122 14
BRK 101 12
EPH-A2 97 3
EPH-A4 109 10
EPH-B1 97 5
EPH-B2 124 15
EPH-B3 118 19
EPH-B4 109 1
FGF-R1 118 7
HER4 132 24
IGF-1R 103 14
IR 112 18
IRR 104 2
TrkA 97 0
DDR2 91 11
VEGFR1 65 15
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 1 1
MKK2 9 0
MKK6 20 15
ERK1 57 3
ERK2 36 3
JNK1 80 3
JNK2 99 3
JNK3 107 5
p38 alpha MAPK 105 13
p38 beta MAPK 98 3
p38 gamma MAPK 114 28
p38 delta MAPK 108 0
ERK8 11 0
RSK1 85 4
RSK2 129 19
PDK1 93 9
PKB alpha 107 3
PKB beta 99 21
SGK1 104 17
S6K1 106 5
PKA 100 18
ROCK 2 99 13
PRK2 89 27
PKC alpha 92 13
PKC gamma 89 0
PKC zeta 105 5
PKD1 11 1
STK33 113 5
MSK1 104 8
MNK1 55 3
MNK2 44 6
MAPKAP-K2 109 22
MAPKAP-K3 99 9
PRAK 32 3
CAMKK beta 94 29
CAMK1 112 6
SmMLCK 96 2
PHK 107 7
DAPK1 96 14
CHK1 94 12
CHK2 106 20
GSK3 beta 113 48
CDK2-Cyclin A 76 2
CDK9-Cyclin T1 111 3
PLK1 114 2
Aurora A 108 5
Aurora B 107 1
TLK1 120 31
LKB1 104 2
AMPK 94 3
MARK1 101 9
MARK2 100 4
MARK3 95 13
MARK4 94 23
BRSK1 82 9
BRSK2 96 3
MELK 104 7
NUAK1 105 16
SIK2 88 10
SIK3 94 7
TSSK1 99 7
CK1 gamma 2 109 6
CK1 delta 92 22
CK2 133 7
TTBK1 112 35
DYRK1A 101 11
DYRK2 102 24
DYRK3 124 6
NEK2a 105 4
NEK6 98 7
IKK beta 112 10
IKK epsilon 92 9
TBK1 93 5
PIM1 92 5
PIM2 117 29
PIM3 99 6
SRPK1 100 4
EF2K 133 26
EIF2AK3 121 48
HIPK1 95 12
HIPK2 72 12
HIPK3 102 4
CLK2 114 24
PAK2 95 13
PAK4 104 31
PAK5 103 20
PAK6 95 13
MST2 102 3
MST3 114 13
MST4 86 1
GCK 97 7
MINK1 102 16
MEKK1 102 13
MLK1 101 7
MLK3 90 9
TESK1 92 12
TAO1 100 5
ASK1 109 4
TAK1 2 1
IRAK1 109 43
IRAK4 57 2
RIPK2 85 6
OSR1 129 30
TTK 101 5
MPSK1 102 4
WNK1 106 3
ULK1 92 15
ULK2 118 35
Src 86 3
Lck 69 8
CSK 95 24
YES1 81 21
ABL 105 5
BTK 109 2
JAK2 109 25
SYK 85 2
ZAP70 103 10
TIE2 122 11
BRK 48 2
EPH-A2 56 3
EPH-A4 107 3
EPH-B1 84 9
EPH-B2 115 0
EPH-B3 92 6
EPH-B4 116 35
FGF-R1 132 24
HER4 105 3
IGF-1R 119 44
IR 97 4
IRR 113 11
TrkA 67 9
DDR2 133 55
VEGFR1 3 0
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 21 5
MKK2 21 1
MKK6 21 12
ERK1 102 9
ERK2 87 17
JNK1 98 8
JNK2 106 6
JNK3 101 18
p38 alpha MAPK 105 6
p38 beta MAPK 93 1
p38 gamma MAPK 105 18
p38 delta MAPK 100 3
ERK8 27 0
RSK1 92 10
RSK2 125 19
PDK1 88 22
PKB alpha 124 2
PKB beta 103 7
SGK1 91 15
S6K1 92 9
PKA 99 3
ROCK 2 94 15
PRK2 101 23
PKC alpha 88 3
PKC gamma 109 4
PKC zeta 78 12
PKD1 41 1
STK33 105 1
MSK1 104 10
MNK1 87 5
MNK2 62 16
MAPKAP-K2 101 4
MAPKAP-K3 99 2
PRAK 72 17
CAMKK beta 99 9
CAMK1 96 13
SmMLCK 102 4
PHK 98 2
DAPK1 108 10
CHK1 93 14
CHK2 91 12
GSK3 beta 106 5
CDK2-Cyclin A 81 9
CDK9-Cyclin T1 117 17
PLK1 107 7
Aurora A 103 6
Aurora B 92 4
TLK1 101 7
LKB1 120 19
AMPK 105 14
MARK1 99 2
MARK2 100 1
MARK3 102 3
MARK4 99 3
BRSK1 90 9
BRSK2 93 12
MELK 100 2
NUAK1 99 3
SIK2 107 2
SIK3 93 7
TSSK1 110 8
CK1 gamma 2 100 2
CK1 delta 101 3
CK2 121 5
TTBK1 82 15
DYRK1A 105 4
DYRK2 105 6
DYRK3 109 3
NEK2a 127 7
NEK6 90 12
IKK beta 100 3
IKK epsilon 105 4
TBK1 112 6
PIM1 87 10
PIM2 114 2
PIM3 98 6
SRPK1 95 11
EF2K 103 4
EIF2AK3 92 5
HIPK1 99 19
HIPK2 86 5
HIPK3 100 0
CLK2 100 3
PAK2 94 6
PAK4 100 5
PAK5 115 2
PAK6 95 4
MST2 89 9
MST3 104 3
MST4 106 9
GCK 105 3
MINK1 111 8
MEKK1 101 13
MLK1 117 4
MLK3 102 0
TESK1 107 6
TAO1 101 2
ASK1 103 3
TAK1 48 5
IRAK1 97 7
IRAK4 99 5
RIPK2 102 8
OSR1 99 4
TTK 95 13
MPSK1 86 30
WNK1 107 1
ULK1 88 1
ULK2 96 2
Src 91 5
Lck 93 1
CSK 105 9
YES1 85 18
ABL 97 4
BTK 115 11
JAK2 101 6
SYK 108 2
ZAP70 101 7
TIE2 101 11
BRK 100 24
EPH-A2 98 5
EPH-A4 122 2
EPH-B1 110 3
EPH-B2 118 2
EPH-B3 130 12
EPH-B4 116 14
FGF-R1 154 18
HER4 104 14
IGF-1R 100 14
IR 116 1
IRR 108 3
TrkA 90 19
DDR2 113 10
VEGFR1 5 2

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