Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
JNKIN7 C28H27N7O2 493.56 JNK Zhang T. (2012) Chem Biol. 19(1) 140-54 Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 98 6
MKK2 87 19
MKK6 97 13
ERK1 110 16
ERK2 99 16
JNK1 9 2
JNK2 81 8
JNK3 15 2
p38 alpha MAPK 98 0
p38 beta MAPK 96 5
p38 gamma MAPK 90 10
p38 delta MAPK 106 7
ERK8 46 5
RSK1 95 21
RSK2 80 11
PDK1 89 14
PKB alpha 92 5
PKB beta 93 13
SGK1 105 20
S6K1 88 2
PKA 97 5
ROCK 2 89 10
PRK2 99 0
PKC alpha 89 4
PKC gamma 96 4
PKC zeta 112 3
PKD1 105 37
STK33 92 8
MSK1 88 9
MNK1 84 16
MNK2 92 5
MAPKAP-K2 91 1
MAPKAP-K3 104 9
PRAK 96 17
CAMKK beta 87 10
CAMK1 87 12
SmMLCK 96 6
PHK 94 10
DAPK1 90 8
CHK1 74 17
CHK2 89 2
GSK3 beta 88 8
CDK2-Cyclin A 85 0
CDK9-Cyclin T1 22 4
PLK1 91 9
Aurora A 107 7
Aurora B 74 1
TLK1 99 7
LKB1 78 3
AMPK 92 12
MARK1 91 9
MARK2 94 1
MARK3 101 5
MARK4 85 3
BRSK1 94 4
BRSK2 82 8
MELK 71 0
NUAK1 35 1
SIK2 78 1
SIK3 81 4
TSSK1 88 3
CK1 gamma 2 88 1
CK1 delta 63 5
CK2 80 1
TTBK1 88 13
DYRK1A 97 2
DYRK2 82 20
DYRK3 81 9
NEK2a 93 1
NEK6 88 12
IKK beta 76 16
IKK epsilon 97 4
TBK1 77 5
PIM1 97 3
PIM2 96 8
PIM3 97 6
SRPK1 105 16
EF2K 97 5
EIF2AK3 90 2
HIPK1 86 11
HIPK2 85 10
HIPK3 113 0
CLK2 49 2
PAK2 102 2
PAK4 84 8
PAK5 89 1
PAK6 87 4
MST2 83 10
MST3 94 3
MST4 98 2
GCK 45 4
MINK1 92 9
MEKK1 85 11
MLK1 72 0
MLK3 79 1
TESK1 90 16
TAO1 96 1
ASK1 96 9
TAK1 67 4
IRAK1 26 14
IRAK4 86 12
RIPK2 74 21
OSR1 99 2
TTK 83 6
MPSK1 108 3
WNK1 103 17
ULK1 37 1
ULK2 50 5
Src 93 9
Lck 95 0
CSK 109 20
YES1 80 17
ABL 77 9
BTK 86 22
JAK2 85 10
SYK 89 17
ZAP70 82 1
TIE2 94 5
BRK 81 11
EPH-A2 110 7
EPH-A4 92 5
EPH-B1 93 9
EPH-B2 101 9
EPH-B3 101 6
EPH-B4 105 2
FGF-R1 94 19
HER4 108 32
IGF-1R 75 22
IR 81 1
IRR 72 1
TrkA 96 24
DDR2 89 7
VEGFR1 59 4
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 113 9
MKK2 102 13
MKK6 91 0
ERK1 109 9
ERK2 114 17
JNK1 4 1
JNK2 19 9
JNK3 16 0
p38 alpha MAPK 113 3
p38 beta MAPK 82 6
p38 gamma MAPK 103 0
p38 delta MAPK 100 4
ERK8 20 8
RSK1 77 31
RSK2 80 4
PDK1 98 4
PKB alpha 104 5
PKB beta 106 18
SGK1 105 9
S6K1 112 4
PKA 108 15
ROCK 2 71 2
PRK2 92 3
PKC alpha 97 8
PKC gamma 101 5
PKC zeta 103 4
PKD1 82 9
STK33 91 12
MSK1 91 6
MNK1 95 23
MNK2 84 21
MAPKAP-K2 106 11
MAPKAP-K3 101 4
PRAK 85 8
CAMKK beta 35 4
CAMK1 92 4
SmMLCK 85 1
PHK 83 0
DAPK1 83 2
CHK1 88 2
CHK2 73 1
GSK3 beta 56 1
CDK2-Cyclin A 72 2
CDK9-Cyclin T1 42 2
PLK1 106 1
Aurora A 97 3
Aurora B 73 1
TLK1 98 8
LKB1 91 18
AMPK 87 4
MARK1 80 1
MARK2 85 2
MARK3 76 2
MARK4 83 16
BRSK1 86 6
BRSK2 76 6
MELK 48 1
NUAK1 82 10
SIK2 67 7
SIK3 64 12
TSSK1 101 7
CK1 gamma 2 88 4
CK1 delta 33 0
CK2 81 10
TTBK1 79 8
DYRK1A 85 6
DYRK2 56 2
DYRK3 79 6
NEK2a 105 21
NEK6 96 0
IKK beta 63 2
IKK epsilon 98 8
TBK1 79 11
PIM1 114 6
PIM2 102 8
PIM3 84 6
SRPK1 104 4
EF2K 101 1
EIF2AK3 99 9
HIPK1 78 10
HIPK2 46 4
HIPK3 101 22
CLK2 18 5
PAK2 93 1
PAK4 66 6
PAK5 91 8
PAK6 103 8
MST2 64 6
MST3 93 15
MST4 104 1
GCK 20 1
MINK1 69 2
MEKK1 100 8
MLK1 39 0
MLK3 59 8
TESK1 98 10
TAO1 95 20
ASK1 100 1
TAK1 39 1
IRAK1 5 0
IRAK4 88 6
RIPK2 42 1
OSR1 105 7
TTK 77 3
MPSK1 103 8
WNK1 117 8
ULK1 63 13
ULK2 69 7
Src 72 10
Lck 101 1
CSK 103 7
YES1 58 4
ABL 85 12
BTK 85 14
JAK2 77 8
SYK 72 5
ZAP70 123 1
TIE2 84 15
BRK 81 16
EPH-A2 125 17
EPH-A4 105 2
EPH-B1 86 19
EPH-B2 103 10
EPH-B3 118 20
EPH-B4 109 6
FGF-R1 95 14
HER4 106 7
IGF-1R 102 8
IR 77 24
IRR 64 6
TrkA 82 11
DDR2 108 9
VEGFR1 32 2

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