Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GSK461364 C27H28F3N5O2S 543.6 PLK1 T. R. Rheault (2010) Bioorg. Med. Chem. Lett. 20(15) 4587-92 K. A. Emmitte (2009) Bioorg. Med. Chem. Lett. 19(6) 1694-7 Axon Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
PLK1 5 0
PRK2 15 2
NEK2a 21 4
PIM1 33 2
NUAK1 35 3
RSK1 35 3
BRSK1 37 5
BRSK2 41 5
PIM3 43 2
MLK1 45 2
TSSK1 50 9
RSK2 51 17
MEKK1 57 1
MLK3 63 2
RIPK2 65 3
TIE2 68 2
ERK8 71 9
MINK1 72 4
CHK2 73 4
SIK3 73 2
Aurora B 75 0
CDK9-Cyclin T1 76 8
Src 78 3
IR 78 1
EPH-A2 78 1
PKD1 79 15
DAPK1 79 19
AMPK 80 3
MKK6 80 6
SRPK1 81 5
MAPKAP-K2 81 1
MKK1 81 3
PAK2 81 8
ROCK 2 81 8
CLK2 82 5
SmMLCK 82 3
MARK3 82 10
GSK3 beta 83 8
MSK1 83 7
VEGFR1 83 4
PAK5 83 2
GCK 84 15
IRAK4 84 4
MARK4 84 12
WNK1 85 3
BTK 85 8
HIPK2 85 4
MELK 86 21
TrkA 86 11
ERK1 86 18
p38 alpha MAPK 87 7
CDK2-Cyclin A 87 9
STK33 87 6
TAK1 87 8
MST2 88 2
CK1 delta 88 7
TTBK1 88 9
PAK4 88 3
JNK3 89 11
FGF-R1 89 31
EF2K 89 2
MNK2 89 5
CAMKK beta 89 5
TESK1 90 7
PKB beta 90 12
DYRK2 90 5
JNK1 90 1
ABL 91 4
DYRK1A 91 1
ERK2 91 12
NEK6 91 10
SIK2 92 2
IRR 92 6
TAO1 92 20
EPH-A4 92 5
Lck 93 0
CSK 93 9
HIPK1 93 3
PKB alpha 93 1
JNK2 93 1
IKK beta 93 7
MPSK1 94 4
p38 gamma MAPK 94 8
S6K1 94 3
MAPKAP-K3 95 10
MARK1 95 3
CAMK1 95 3
TTK 96 1
TBK1 96 7
PAK6 96 13
CHK1 97 11
LKB1 97 8
ZAP70 97 0
MST3 98 3
HER4 98 0
MKK2 98 10
DYRK3 98 13
PHK 98 2
p38 beta MAPK 99 1
PIM2 99 2
JAK2 99 8
MARK2 99 1
IRAK1 99 8
PKA 99 6
p38 delta MAPK 100 1
PRAK 100 1
SGK1 100 2
IKK epsilon 101 14
MNK1 101 28
PKC gamma 102 11
YES1 102 20
ASK1 102 9
EPH-B1 103 10
OSR1 103 11
Aurora A 104 3
CK1 gamma 2 104 2
CK2 104 10
EPH-B3 105 7
PDK1 105 5
PKC alpha 109 15
PKC zeta 109 14
IGF-1R 110 5
TLK1 110 7
DDR2 111 10
EIF2AK3 112 17
SYK 112 12
BRK 113 24
MST4 114 7
HIPK3 118 5
EPH-B4 122 13
EPH-B2 130 7
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
PLK1 6 2
PRK2 52 4
NEK2a 66 6
NUAK1 75 7
RSK1 76 3
IR 77 1
PIM1 77 3
MINK1 79 13
CK1 gamma 2 79 13
Aurora B 80 8
MARK3 80 3
MKK1 80 6
PIM3 81 2
TSSK1 81 7
DAPK1 81 0
MARK1 82 1
PAK2 83 1
MAPKAP-K2 83 2
IRAK4 83 10
MLK1 84 3
MAPKAP-K3 85 2
Src 85 3
EPH-A2 85 2
CSK 86 7
IGF-1R 86 3
BRSK1 86 4
MST3 86 12
MST4 86 1
SIK2 86 11
RSK2 87 21
MKK2 87 10
GSK3 beta 87 16
RIPK2 87 5
CDK9-Cyclin T1 88 3
TAK1 88 5
MARK2 88 11
BRSK2 88 9
CHK2 88 5
CLK2 89 13
PHK 89 8
IKK epsilon 89 3
EIF2AK3 90 32
CK2 90 5
p38 alpha MAPK 90 5
DYRK3 90 2
MLK3 91 1
MST2 91 5
AMPK 92 2
MARK4 92 7
IKK beta 92 12
SRPK1 93 12
SmMLCK 93 1
STK33 93 5
TIE2 93 2
S6K1 93 10
ERK2 94 8
JNK1 94 4
MNK2 94 6
CK1 delta 94 4
p38 gamma MAPK 94 2
IRR 94 3
CHK1 94 9
SIK3 95 14
EF2K 95 7
LKB1 95 7
HER4 95 9
CAMKK beta 95 5
CAMK1 95 4
MSK1 95 5
MEKK1 96 7
MPSK1 96 5
TAO1 96 5
p38 delta MAPK 96 9
NEK6 96 0
PKD1 96 11
PDK1 96 1
PKB beta 96 4
WNK1 97 4
TESK1 97 16
p38 beta MAPK 97 4
PAK5 97 3
VEGFR1 97 2
MELK 97 5
CDK2-Cyclin A 97 12
GCK 97 6
JNK3 98 10
HIPK1 98 11
ROCK 2 98 10
DYRK1A 98 7
ERK8 98 10
PAK6 98 6
PRAK 99 8
PKA 99 8
TTBK1 99 2
DYRK2 99 3
MNK1 100 24
TTK 100 3
HIPK2 100 4
ABL 100 5
BTK 100 9
SGK1 100 6
ERK1 100 5
EPH-B1 101 3
PKB alpha 101 11
PIM2 101 12
IRAK1 102 2
MKK6 102 22
OSR1 103 18
JNK2 103 19
TrkA 103 0
ZAP70 103 5
JAK2 105 8
Aurora A 106 11
Lck 106 4
PAK4 107 4
EPH-B4 108 1
PKC gamma 108 17
TBK1 109 1
EPH-B2 110 2
PKC alpha 112 8
EPH-B3 114 4
ASK1 115 15
FGF-R1 117 14
TLK1 118 6
DDR2 118 6
BRK 118 16
YES1 120 21
PKC zeta 120 7
EPH-A4 122 1
HIPK3 122 7
SYK 122 6

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