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Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GSK461364 C27H28F3N5O2S 543.6 PLK1 T. R. Rheault (2010) Bioorg. Med. Chem. Lett. 20(15) 4587-92 K. A. Emmitte (2009) Bioorg. Med. Chem. Lett. 19(6) 1694-7 Axon Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 81 3
MKK2 98 10
MKK6 80 6
ERK1 86 18
ERK2 91 12
JNK1 90 1
JNK2 93 1
JNK3 89 11
p38 alpha MAPK 87 7
p38 beta MAPK 99 1
p38 gamma MAPK 94 8
p38 delta MAPK 100 1
ERK8 71 9
RSK1 35 3
RSK2 51 17
PDK1 105 5
PKB alpha 93 1
PKB beta 90 12
SGK1 100 2
S6K1 94 3
PKA 99 6
ROCK 2 81 8
PRK2 15 2
PKC alpha 109 15
PKC gamma 102 11
PKC zeta 109 14
PKD1 79 15
STK33 87 6
MSK1 83 7
MNK1 101 28
MNK2 89 5
MAPKAP-K2 81 1
MAPKAP-K3 95 10
PRAK 100 1
CAMKK beta 89 5
CAMK1 95 3
SmMLCK 82 3
PHK 98 2
DAPK1 79 19
CHK1 97 11
CHK2 73 4
GSK3 beta 83 8
CDK2-Cyclin A 87 9
CDK9-Cyclin T1 76 8
PLK1 5 0
Aurora A 104 3
Aurora B 75 0
TLK1 110 7
LKB1 97 8
AMPK 80 3
MARK1 95 3
MARK2 99 1
MARK3 82 10
MARK4 84 12
BRSK1 37 5
BRSK2 41 5
MELK 86 21
NUAK1 35 3
SIK2 92 2
SIK3 73 2
TSSK1 50 9
CK1 gamma 2 104 2
CK1 delta 88 7
CK2 104 10
TTBK1 88 9
DYRK1A 91 1
DYRK2 90 5
DYRK3 98 13
NEK2a 21 4
NEK6 91 10
IKK beta 93 7
IKK epsilon 101 14
TBK1 96 7
PIM1 33 2
PIM2 99 2
PIM3 43 2
SRPK1 81 5
EF2K 89 2
EIF2AK3 112 17
HIPK1 93 3
HIPK2 85 4
HIPK3 118 5
CLK2 82 5
PAK2 81 8
PAK4 88 3
PAK5 83 2
PAK6 96 13
MST2 88 2
MST3 98 3
MST4 114 7
GCK 84 15
MINK1 72 4
MEKK1 57 1
MLK1 45 2
MLK3 63 2
TESK1 90 7
TAO1 92 20
ASK1 102 9
TAK1 87 8
IRAK1 99 8
IRAK4 84 4
RIPK2 65 3
OSR1 103 11
TTK 96 1
MPSK1 94 4
WNK1 85 3
Src 78 3
Lck 93 0
CSK 93 9
YES1 102 20
ABL 91 4
BTK 85 8
JAK2 99 8
SYK 112 12
ZAP70 97 0
TIE2 68 2
BRK 113 24
EPH-A2 78 1
EPH-A4 92 5
EPH-B1 103 10
EPH-B2 130 7
EPH-B3 105 7
EPH-B4 122 13
FGF-R1 89 31
HER4 98 0
IGF-1R 110 5
IR 78 1
IRR 92 6
TrkA 86 11
DDR2 111 10
VEGFR1 83 4
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 80 6
MKK2 87 10
MKK6 102 22
ERK1 100 5
ERK2 94 8
JNK1 94 4
JNK2 103 19
JNK3 98 10
p38 alpha MAPK 90 5
p38 beta MAPK 97 4
p38 gamma MAPK 94 2
p38 delta MAPK 96 9
ERK8 98 10
RSK1 76 3
RSK2 87 21
PDK1 96 1
PKB alpha 101 11
PKB beta 96 4
SGK1 100 6
S6K1 93 10
PKA 99 8
ROCK 2 98 10
PRK2 52 4
PKC alpha 112 8
PKC gamma 108 17
PKC zeta 120 7
PKD1 96 11
STK33 93 5
MSK1 95 5
MNK1 100 24
MNK2 94 6
MAPKAP-K2 83 2
MAPKAP-K3 85 2
PRAK 99 8
CAMKK beta 95 5
CAMK1 95 4
SmMLCK 93 1
PHK 89 8
DAPK1 81 0
CHK1 94 9
CHK2 88 5
GSK3 beta 87 16
CDK2-Cyclin A 97 12
CDK9-Cyclin T1 88 3
PLK1 6 2
Aurora A 106 11
Aurora B 80 8
TLK1 118 6
LKB1 95 7
AMPK 92 2
MARK1 82 1
MARK2 88 11
MARK3 80 3
MARK4 92 7
BRSK1 86 4
BRSK2 88 9
MELK 97 5
NUAK1 75 7
SIK2 86 11
SIK3 95 14
TSSK1 81 7
CK1 gamma 2 79 13
CK1 delta 94 4
CK2 90 5
TTBK1 99 2
DYRK1A 98 7
DYRK2 99 3
DYRK3 90 2
NEK2a 66 6
NEK6 96 0
IKK beta 92 12
IKK epsilon 89 3
TBK1 109 1
PIM1 77 3
PIM2 101 12
PIM3 81 2
SRPK1 93 12
EF2K 95 7
EIF2AK3 90 32
HIPK1 98 11
HIPK2 100 4
HIPK3 122 7
CLK2 89 13
PAK2 83 1
PAK4 107 4
PAK5 97 3
PAK6 98 6
MST2 91 5
MST3 86 12
MST4 86 1
GCK 97 6
MINK1 79 13
MEKK1 96 7
MLK1 84 3
MLK3 91 1
TESK1 97 16
TAO1 96 5
ASK1 115 15
TAK1 88 5
IRAK1 102 2
IRAK4 83 10
RIPK2 87 5
OSR1 103 18
TTK 100 3
MPSK1 96 5
WNK1 97 4
Src 85 3
Lck 106 4
CSK 86 7
YES1 120 21
ABL 100 5
BTK 100 9
JAK2 105 8
SYK 122 6
ZAP70 103 5
TIE2 93 2
BRK 118 16
EPH-A2 85 2
EPH-A4 122 1
EPH-B1 101 3
EPH-B2 110 2
EPH-B3 114 4
EPH-B4 108 1
FGF-R1 117 14
HER4 95 9
IGF-1R 86 3
IR 77 1
IRR 94 3
TrkA 103 0
DDR2 118 6
VEGFR1 97 2

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