Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

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Inhibitor Brutto MW Action Reference Reference 2
Cot-Tpl2 Inhibitor Compound 41 (Abbott)   C21H14N6O2S 414.44 Cot-Tpl2 George D. Friedman M. (2008) Bioorganic and Medicinal Chemistry Letters 18 495…
CP-690550 (Tasocitinib)   C16H20N6O 312.38 JAKs Manshouri T. (2008) Cancer Sci. 99(6) 1265-73
Crenolanib   C26H29N5O2 443.50 FLT3 Smith CC (2014 )Proc Natl Acad Sci U S A Apr 8 111(14) 5319-24
Crizotinib   C21H22Cl2FN5O ALK, MET
Curcumin   C21H20O6 368.40 Inhibits EGF receptor Cui L. (2007) Antimicrob. Agents Chemother. 51 488 Salvioli S. (2007) eCAM 4 181
CZC-25146   C22H25FN6O4S 488.54 LRRK2 Ramsden N. (2011) ASC Chemical Biology
D 4476   C23H18N4O3 398.41 CK1 Liverton N.J. (1999) J. Med. Chem 42 2180-2190
Dabrafenib   C23H20F3N5O2S2 BRAF
Dacomitinib   C24H25ClFN5O2 469.90 mutant EGFR
Dasatinib   C22H26ClN7O2S 487.00 BCR-ABL, Src, Multiple Tyrosine kinases targeted Kantarjian H. N Engl J Med. (2010) 2260-70
Defactinib C20H21F3N8O3S 510.50 PTK2; Pyk2; MELK
Delgocitinib   C16H18N6O 310.35 JAK
Deucravacitinib   C20H22N8O3 425.50 TYK2
Dimethyl fumarate C6H8O4 144.13 Peng H. (2112) J Biol Chem. 287(33) 28017-26 Gesser B. (2007) Journal of Investigative Dermatology 27(9) 2129-37
dTAG-13   C57H68N4O15 1049.18 degrader for FKBP12/f36v
Duvelisib   C22H17ClN6O 416.90 PI3K δ/ γ
EGCG (Epigallocatechin Gallate)   C22H18O11 458.40 PKC Dell'Aica I. (2004) EMBO Rep. 5 418-422 Tachibana H. (2004) Nat. Struct. Mol. Biol. 11 380
EMD638683   C18H18F2N 364.34 SGK1 Miyayama T (2014) Environ Toxicol Pharmacol 38(2) 374-8
Encorafenib   C22H27ClFN7O4S 540.00 MEK/RAF
Entrectinib   C31H34F2N6O2 560.60 NTRK1/2/3 ROS1; ALK
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